Possible nirmatrelvir/ritonavir-induced bradycardia in a patient with asymptomatic COVID-19.

COVID-19 emerged in 2019 and was declared a pandemic by the World Health Organization in March 2020. COVID-19 is highly transmissible and can lead to bilateral pneumonia with severe respiratory failure. COVID-19 has led to more than 6.5 million deaths worldwide. The significant morbidity and mortality due to COVID-19 have resulted in the development of treatment modalities, such as novel antivirals, to reduce hospitalizations and progression of disease. In 2021, the US Food and Drug Administration authorized nirmatrelvir/ritonavir for emergency use in nonhospitalized patients with COVID-19. Nirmatrelvir is a newly developed protease inhibitor and is combined with a commonly used pharmacokinetic boosting agent, ritonavir. Given the novelty of nirmatrelvir/ritonavir, potential adverse effects remain uncertain. In this case, we describe a patient who was initiated on a course of nirmatrelvir/ritonavir and developed symptomatic bradycardia.

Meropenem resistant Lactobacillus endocarditis in an immunocompetent patient.

Lactobacilli are gram-positive bacteria usually found in the normal flora and are commonly used as probiotic treatments for vaginal candidiasis. Lactobacilli are normally considered non-pathogenic; however, certain risk factors can make a patient susceptible to severe infections. This case describes an immunocompetent 61-year-old female with an automated intracardiac defibrillator who presented with a 10-day history of nausea and vomiting. Furthermore, diagnostic tests, including a transesophageal echocardiography, revealed a large vegetation, and blood cultures were consistently positive for Lactobacillus. The patient was treated with intravenous penicillin and gentamicin, along with removal of the automated intracardiac defibrillator. In patients with significant underlying conditions, physicians should consider Lactobacillus as a causative organism to avoid delays in treatment.

Use of tocilizumab, remdesivir, and high-dose methylprednisolone prevents intubation in an ESRD patient with COVID-19 pneumonia.

Coronavirus disease 2019 (COVID-19) has affected over 200 million patients worldwide. COVID-19 is transmitted through respiratory droplets from patient to patient or by touching a surface that has been contaminated by an infected patient. Many COVID-19 patients have other comorbidities, such as end-stage renal disease. Currently, management of COVID-19 in patients with end-stage renal disease is unclear. Some studies have shown improvement in this population with the use of tocilizumab, a humanized interleukin-6 monoclonal antibody, in addition to the standard therapy as per guidelines published by the National Institutes of Health. In this case report, we present a patient case where the use of remdesivir, tocilizumab, and pulse-dose methylprednisolone significantly improved symptoms and inflammatory biomarkers associated with COVID-19 in a patient with end-stage renal disease.