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1.
Small ; : e2401656, 2024 Jul 12.
Artigo em Inglês | MEDLINE | ID: mdl-38994827

RESUMO

Electrochemical CO2 reduction is a promising technology for replacing fossil fuel feedstocks in the chemical industry but further improvements in catalyst selectivity need to be made. So far, only copper-based catalysts have shown efficient conversion of CO2 into the desired multi-carbon (C2+) products. This work explores Cu-based dilute alloys to systematically tune the energy landscape of CO2 electrolysis toward C2+ products. Selection of the dilute alloy components is guided by grand canonical density functional theory simulations using the calculated binding energies of the reaction intermediates CO*, CHO*, and OCCO* dimer as descriptors for the selectivity toward C2+ products. A physical vapor deposition catalyst testing platform is employed to isolate the effect of alloy composition on the C2+/C1 product branching ratio without interference from catalyst morphology or catalyst integration. Six dilute alloy catalysts are prepared and tested with respect to their C2+/C1 product ratio using different electrolyzer environments including selected tests in a 100-cm2 electrolyzer. Consistent with theory, CuAl, CuB, CuGa and especially CuSc show increased selectivity toward C2+ products by making CO dimerization energetically more favorable on the dominant Cu facets, demonstrating the power of using the dilute alloy approach to tune the selectivity of CO2 electrolysis.

2.
J Proteome Res ; 2024 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-39024330

RESUMO

Ferroptosis adversely affects the viability, differentiation, and metabolic integrity of C2C12 myoblasts, contributing to the decline in skeletal muscle health. The intricate mechanisms behind this process are not fully understood. In this study, we induced ferroptosis in myoblasts using targeted inducers and found a marked decrease in specific redox metabolites, particularly taurine. Taurine supplementation effectively reversed the deleterious effects of ferroptosis, significantly increased cellular glutathione levels, reduced MDA and ROS levels, and rejuvenated impaired myogenic differentiation. Furthermore, taurine downregulated HO-1 expression and decreased intracellular Fe2+ levels, thereby stabilizing the labile iron pool. Using NMR metabolomic analysis, we observed that taurine profoundly promoted glycerophospholipid metabolism, which is critical for cell membrane repair, and enhanced mitochondrial bioenergetics, thereby increasing the energy reserves essential for muscle satellite cell regeneration. These results suggest that taurine is a potent ferroptosis inhibitor that attenuates key drivers of this process, strengthens oxidative defenses, and improves redox homeostasis. This combined effect protects cells from ferroptosis-induced damage. This study highlights the potential of taurine as a valuable ferroptosis inhibitor that protects skeletal muscle from ferroptosis-induced damage and provides a basis for therapeutic strategies to rejuvenate and facilitate the regeneration of aging skeletal muscle.

3.
Water Sci Technol ; 89(11): 3104-3121, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38877633

RESUMO

Coastal wetlands are the main distribution of blue carbon in coastal zones and well known for their high carbon sequestration capacity. Investigating the variation of carbon budget is crucial for understanding the functionality of coastal wetlands and effectively addressing climate change. In this study, a bibliometric analysis of 4,509 articles was conducted to reveal research progress, hot issues, and emerging trends in the coastal wetland carbon budget field. The number of publications and citations in this field increased exponentially from 1991 to 2022. The leading subject category was Environmental Sciences with 1,844 articles (40.9%). At present, studies have been focused on blue carbon, the effects of climate change and man-made disturbances on carbon cycle, and the restoration of coastal wetlands. Based on the hotspots and trends in this field, the future researches should include (1) exploring the functional mechanisms of various factors affecting carbon cycle and establishing a methodological system for the estimation of blue carbon in coastal wetlands; (2) researching restoration techniques of coastal wetland and constructing wetland restoration evaluation index system; and (3) formulating enforceable carbon trading policy and strengthening international cooperation.


Assuntos
Bibliometria , Carbono , Áreas Alagadas , Carbono/metabolismo , Mudança Climática
4.
Environ Int ; 190: 108841, 2024 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-38917626

RESUMO

OBJECTIVES: Evidence on the link between long-term ambient particulate matter (PM) exposures and childhood sleep disorders were scarce. We examined the associations between long-term exposures to PM2.5 and PM1 (PM with an aerodynamic equivalent diameter <2.5 µm and <1 µm, respectively) with sleep disorders in children. METHODS: We performed a population-based cross-sectional survey in 177,263 children aged 6 to 18 years in 14 Chinese cities during 2012-2018. A satellite-based spatiotemporal model was employed to estimate four-year annual average PM2.5 and PM1 exposures at residential and school addresses. Parents or guardians completed a checklist using the Sleep Disturbance Scale for Children. We estimated the associations using generalized linear mixed models with adjustment for characteristics of children, parents, and indoor environments. RESULTS: Long-term PM2.5 and PM1 exposures were positively associated with odds of sleep disorders for almost all domains. For example, increments in PM2.5 and PM1 per 10 µg/m3 were associated with odds ratios of global sleep disorder of 1.24 (95 % confidence interval [CI]: 1.14, 1.35) and 1.31 (95 %CI: 1.18, 1.46), respectively. Similar results were observed for subtypes of sleep disorder. These associations were heterogeneous regionally, with stronger associations among children residing in southeast region than in northeast and northwest regions. Moreover, larger estimates of PM1 were found than that of PM2.5 in southeast region. CONCLUSION: Long-term PM2.5 and PM1 exposures are independently associated with higher risks of childhood sleep disorders, and these associations vary by geographical region.

5.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 32(3): 774-779, 2024 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-38926966

RESUMO

OBJECTIVE: To investigate the efficacy and safety of a treatment regimen based on daratumumab in patients with high-risk relapsed refractory multiple myeloma(MM) with mSMART 3.0 score. METHODS: Clinical data were collected from 16 patients with mSMART3.0 score high-risk relapsed refractory MM treated at the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from May 2020 to May 2023, all of whom received daltezumab-based regimen (regimen drugs including dexamethasone, isazomib, bortezomib, lenalidomide). The efficacy and safety of the treatment were retrospectively analyzed. RESULTS: The median age of 16 patients was 63.5 (47-70) years old, including 10 cases of IgG type, 2 cases of IgA type, and 4 cases of light chain type. The curative efficacy was judged in all 16 patients, with an overall response rate of 93.75% (15/16), including 4 cases of strict complete remission (sCR), 1 case of complete remission (CR), 2 case of very good partial remission (VGPR), partial remission (PR) in 5 cases, and minor remission (MR) in 3 cases. The median follow-up time was 11(2-30) months, and the median progression-free survival and median overall survival were not achieved in 16 patients at the median follow-up period. The hematologic adverse effects of the treatment regimen using daratumumab-based were mainly neutropenia, and the non-hematologic adverse effects were mainly infusion-related adverse reactions and infections. CONCLUSION: Daratumumab-based regimen for the treatment of relapsed refractory MM patients with high risk of mSMART3.0 score has better efficacy and safety.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica , Mieloma Múltiplo , Humanos , Mieloma Múltiplo/tratamento farmacológico , Pessoa de Meia-Idade , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Masculino , Estudos Retrospectivos , Feminino , Anticorpos Monoclonais/uso terapêutico , Dexametasona/administração & dosagem , Dexametasona/uso terapêutico , Resultado do Tratamento , Anticorpos Monoclonais Humanizados/uso terapêutico , Lenalidomida/administração & dosagem , Bortezomib
6.
J Ultrasound ; 2024 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-38904735

RESUMO

PURPOSE: This is an extremely rare case of complicated fetal esophageal atresia (EA) with tracheoesophageal fistula (TEF) and interrupted inferior vena cava (IVC) diagnosed by prenatal ultrsonography and successfully treated with surgical repair. METHODS: A 35-year-old pregnant woman was referred to our center for prenatal ultrasound, and the fetus was found to have a series of abnormalities, such as an interrupted IVC associated with a dilated azygos vein, an upper neck pouch sign of the thorax, and polyhydramnios. With suspicion of EA with TEF and interrupted IVC, the infant was born at 39 weeks of gestation, and successfully underwent the surgical operation. RESULTS: The baby was doing well after 21 months of follow-up. CONCLUSION: It is beneficial for the prenatal ultrasonic diagnosis of EA with TEF in optimizing labor care, postpartum treatment, and prompting neonatal management.

7.
bioRxiv ; 2024 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-38895215

RESUMO

A BEM (boundary element method) based approach is developed to accurately solve an EEG/MEG forward problem for a modern high-resolution head model in approximately 60 seconds using a common workstation. The method utilizes a charge-based BEM with fast multipole acceleration (BEM-FMM) and a "smart" mesh pre-refinement (called b-refinement) close to the singular source(s). No costly matrix-filling or direct solution steps typical for the standard BEM are required; the method generates on-skin voltages as well as MEG magnetic fields for high-resolution head models in approximately 60 seconds after initial model assembly. The method is verified both theoretically and experimentally.

8.
Ecotoxicol Environ Saf ; 278: 116400, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38718725

RESUMO

Evidence increasingly suggests molybdenum exposure at environmental levels is still associated with adverse human health, emphasizing the necessity to establish a more protective reference dose (RfD). Herein, we conducted a study measuring 15 urinary metals and 30 clinical health indicators in 2267 participants residing near chemical enterprises across 11 Chinese provinces to investigate their relationships. The kidney and cystatin-C emerged as the most sensitive organ and critical effect indicator of molybdenum exposure, respectively. Odds of cystatin-C-defined chronic kidney disease (CKD) in the highest quantile of molybdenum exposure significantly increased by 133.5% (odds ratio [OR]: 2.34, 95% CI: 1.78, 3.11) and 75.8% (OR: 1.76, 95% CI: 1.24, 2.49) before and after adjusting for urinary 14 metals, respectively. Intriguingly, cystatin-C significantly mediated 15.9-89.5% of molybdenum's impacts on liver and lung function, suggesting nephrotoxicity from molybdenum exposure may trigger hepatotoxicity and pulmonary toxicity. We derived a new RfD for molybdenum exposure (0.87 µg/kg-day) based on cystatin-C-defined estimated glomerular filtration rate by employing Bayesian Benchmark Dose modeling analysis. This RfD is significantly lower than current exposure guidance values (5-30 µg/kg-day). Remarkably, >90% of participants exceeded the new RfD, underscoring the significant health impacts of environmental molybdenum exposure on populations in industrial regions of China.


Assuntos
Molibdênio , Molibdênio/urina , Molibdênio/toxicidade , Molibdênio/análise , Humanos , China/epidemiologia , Feminino , Masculino , Adulto , Pessoa de Meia-Idade , Exposição Ambiental/estatística & dados numéricos , Exposição Ambiental/análise , Cistatina C , Medição de Risco , Poluentes Ambientais/urina , Poluentes Ambientais/análise , Adulto Jovem , Teorema de Bayes , Insuficiência Renal Crônica/epidemiologia , Insuficiência Renal Crônica/induzido quimicamente , Idoso , Indústria Química , Rim/efeitos dos fármacos , Taxa de Filtração Glomerular/efeitos dos fármacos
9.
Environ Sci Pollut Res Int ; 31(26): 38323-38342, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38801608

RESUMO

The water source reservoirs are the important urban water source in northern China. Although external pollution has been greatly improved, the internal pollutants in reservoirs continue to accumulate with the complex deposition and release processes, resulting in potential risks to water supply safety. To address the aforementioned issue, this paper proposed a simulation model of water quality named ECOlab EU1-WSR to simulate the spatio-temporal changes of water quality under the influence of internal pollution for the water source reservoirs. Based on the analysis of the water quality characteristics and the distribution of benthic vegetation in the reservoir, a three-dimensional hydrodynamic model was established based on MIKE3, the corresponding parameters and the related state variables were set, the ECOlab EU1-WSR model was established by secondly developing the original ECOlab EU1 template, and the real-time dynamic outputs of pollutant content in sediment were added to link the water quality index with sediment nutrition index for better revealing the impact of the internal pollution on the water quality. The performance of the model was evaluated by the case application on the water quality simulation of Daye reservoir and the optimization of the connection project between Daye reservoir and Xueye reservoir in Shandong Province China. The results showed that the model can accurately and simultaneously simulate the pollution in water and sediment by the comparative verification of hydrodynamics, water temperature, and water quality. Moreover, the model can effectively reflect the influence of the accumulation, deposition, and release of internal pollution on water quality by analyzing the correlation between the content of various pollution in water body and those in sediment, such as the total nitrogen and total phosphorus in the water body at the bottom of the water intake, were negatively correlated with the total nitrogen and total phosphorus in the sediments with correlation coefficients of 0.538 and 0.917, respectively. In addition, the optimal water inlet position and water flow rate of the connection project can be optimized and determined by using the model to effectively control water quality. The established model will be a useful tool for the design and management of a reservoir, the interconnection projects, and other water bodies by adaptively recoded.


Assuntos
Monitoramento Ambiental , Qualidade da Água , Abastecimento de Água , China , Poluição da Água , Modelos Teóricos , Poluentes Químicos da Água/análise
10.
Angew Chem Int Ed Engl ; : e202407385, 2024 May 12.
Artigo em Inglês | MEDLINE | ID: mdl-38736176

RESUMO

Circularly polarized luminescence (CPL) is promising for applications in many fields. However, most systems involving CPL are within the visible range; near-infrared (NIR) CPL-active materials, especially those that exhibit high glum values and can be controlled spatially and temporally, are rare. Herein, dynamic NIR-CPL with a glum value of 2.5×10-2 was achieved through supramolecular coassembly and energy-transfer strategies. The chiral assemblies formed by the coassembly between adenosine triphosphate (ATP) and a pyrene derivative exhibited a red CPL signal (glum of 10-3). The further introduction of sulfo-cyanine5 resulted in a energy-transfer process, which not only led to the NIR CPL but also increased the glum value to 10-2. Temporal control of these chiral assemblies was realized by introducing alkaline phosphatase to fabricate a biomimetic enzyme-catalyzed network, allowing the dynamic NIR CPL signal to be turned on. Based on these enzyme-regulated temporally controllable dynamic CPL-active chiral assemblies, a multilevel information encryption system was further developed. This study provides a pioneering example for the construction of dynamic NIR CPL materials with the ability to perform temporal control via the supramolecular assembly strategy, which is expected to aid in the design of supramolecular complex systems that more closely resemble natural biological systems.

11.
Molecules ; 29(10)2024 May 09.
Artigo em Inglês | MEDLINE | ID: mdl-38792078

RESUMO

Disuse muscle atrophy (DMA) is a significant healthcare challenge characterized by progressive loss of muscle mass and function resulting from prolonged inactivity. The development of effective strategies for muscle recovery is essential. In this study, we established a DMA mouse model through hindlimb suspension to evaluate the therapeutic potential of lactate in alleviating the detrimental effects on the gastrocnemius muscle. Using NMR-based metabolomic analysis, we investigated the metabolic changes in DMA-injured gastrocnemius muscles compared to controls and evaluated the beneficial effects of lactate treatment. Our results show that lactate significantly reduced muscle mass loss and improved muscle function by downregulating Murf1 expression, decreasing protein ubiquitination and hydrolysis, and increasing myosin heavy chain levels. Crucially, lactate corrected perturbations in four key metabolic pathways in the DMA gastrocnemius: the biosynthesis of phenylalanine, tyrosine, and tryptophan; phenylalanine metabolism; histidine metabolism; and arginine and proline metabolism. In addition to phenylalanine-related pathways, lactate also plays a role in regulating branched-chain amino acid metabolism and energy metabolism. Notably, lactate treatment normalized the levels of eight essential metabolites in DMA mice, underscoring its potential as a therapeutic agent against the consequences of prolonged inactivity and muscle wasting. This study not only advances our understanding of the therapeutic benefits of lactate but also provides a foundation for novel treatment approaches aimed at metabolic restoration and muscle recovery in conditions of muscle wasting.


Assuntos
Ácido Láctico , Metabolômica , Músculo Esquelético , Animais , Camundongos , Metabolômica/métodos , Ácido Láctico/metabolismo , Músculo Esquelético/metabolismo , Músculo Esquelético/patologia , Músculo Esquelético/efeitos dos fármacos , Atrofia Muscular/metabolismo , Atrofia Muscular/etiologia , Atrofia Muscular/tratamento farmacológico , Atrofia Muscular/patologia , Modelos Animais de Doenças , Espectroscopia de Ressonância Magnética , Masculino , Proteínas Musculares/metabolismo , Transtornos Musculares Atróficos/metabolismo , Transtornos Musculares Atróficos/tratamento farmacológico , Transtornos Musculares Atróficos/patologia , Ubiquitina-Proteína Ligases/metabolismo , Metaboloma/efeitos dos fármacos , Elevação dos Membros Posteriores , Proteínas com Motivo Tripartido/metabolismo , Camundongos Endogâmicos C57BL , Cadeias Pesadas de Miosina/metabolismo
12.
Environ Pollut ; 351: 124091, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38697248

RESUMO

Direct current (DC) electric field has shown promising performance in contaminated site remediation, in which the Joule heating effect plays an important role but has been previously underappreciated. This study focuses on the spatiotemporal characteristics and mechanism of temperature change in heterogeneous porous media with applied DC. The heating process can be divided into four phases: preferential heating of the low permeability zone (LPZ), rapid heating in the middle region, temperature drop and hot zone shift, and reheating. The dynamic ion behaviors with complex interplays among reactions, electrokinetic-driven migration, and mixed convection induced an uneven redistribution of ions and dominated the heating rate and temperature distribution. The concentration of major ions near the pH jump decreased to 1% of the initial value, even though ions were continuously pumped into the heating zone. This ion depletion caused a drop in current, heating rate, and temperature. Here ions cannot be delivered rapidly into the ion-depleted zone by electromigration due to the potential flattening in the surrounding region. The presence of LPZ intensified the nonuniformity of ion redistribution, where a regional focusing of water-soluble ions was observed, and weakened the temperature rebound compared with that using homogeneous sand. These results provide a new perspective on the regulation of DC heating in site remediation.


Assuntos
Recuperação e Remediação Ambiental , Água Subterrânea , Íons , Temperatura , Água Subterrânea/química , Recuperação e Remediação Ambiental/métodos , Poluentes Químicos da Água/análise , Eletricidade
13.
bioRxiv ; 2024 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-38645100

RESUMO

Across all domains of brain stimulation (neuromodulation), conventional analysis of neuron activation involves two discrete steps: i) prediction of macroscopic electric field, ignoring presence of cells and; ii) prediction of cell activation from tissue electric fields. The first step assumes that current flow is not distorted by the dense tortuous network of cell structures. The deficiencies of this assumption have long been recognized, but - except for trivial geometries - ignored, because it presented intractable computation hurdles. This study introduces a novel approach for analyzing electric fields within a microscopically realistic brain volume. Our pipeline overcomes the technical intractability that prevented such analysis while also showing significant implications for brain stimulation. Contrary to the standard finite element method (FEM), we suggest using a nested iterative boundary element method (BEM) coupled with the fast multipole method (FMM). This approach allows for solving problems with multiple length scales more efficiently. A target application is a subvolume of the L2/3 P36 mouse primary visual cortex containing approximately 400 detailed densely packed neuronal cells at a resolution of 100 nm, which is obtained from scanning electron microscopy data. Our immediate result is a reduction of the stimulation field strength necessary for neuron activation by a factor of 0.85-0.55 (by 15%-45%) as compared to macroscopic predictions. This is in line with modern experimental data stating that existing macroscopic theories substantially overestimate electric field levels necessary for brain stimulation.

14.
J Hazard Mater ; 470: 134226, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38593665

RESUMO

Contaminants may induce immune response polarization, leading to immune diseases, such as allergic diseases. Evidence concerning the effects of chlorinated paraffins (CPs), an emerging persistent organic pollutant, on immune system is scarce, particularly for epidemiological evidence. This study explores the association between CPs exposure and allergic diseases (allergic rhinitis, atopic eczema, and allergic conjunctivitis) in children and adolescents in the Pearl River Delta (PRD) in China. Herein, 131,304 children and adolescents from primary and secondary schools in the PRD were included and completed the questionnaire survey. The particulate matter (PM) samples were collected in the PRD and the PM2.5-bound CP concentrations were analyzed. In the multivarious adjustment mixed effect model (MEM), an IQR increase in ∑CPs was significantly associated with allergic diseases (rhinitis, eczema, and conjunctivitis) with the estimated odds ratios (ORs) for 1.11 (95% CI: 1.10, 1.13), 1.17 (95% CI: 1.15, 1.19), and 1.82 (95% CI: 1.76, 1.88), respectively. Interaction analysis indicated that overweight and obese individuals might have greater risk. Similar effect estimates were observed in several sensitivity analyses. This study provided epidemiological evidence on the immunotoxicity of CPs. More studies to confirm our findings and investigate mechanisms are needed.


Assuntos
Parafina , Humanos , Adolescente , Criança , Masculino , Feminino , China/epidemiologia , Parafina/toxicidade , Parafina/análise , Hipersensibilidade/epidemiologia , Exposição Ambiental/efeitos adversos , Hidrocarbonetos Clorados/toxicidade , Hidrocarbonetos Clorados/análise , Poluentes Atmosféricos/toxicidade , Poluentes Atmosféricos/análise , Material Particulado/toxicidade , Material Particulado/análise , Dermatite Atópica/epidemiologia , Dermatite Atópica/induzido quimicamente , Rinite Alérgica/epidemiologia , Rinite Alérgica/induzido quimicamente
15.
J Cell Physiol ; 2024 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-38686599

RESUMO

Lactate can serve as both an energy substrate and a signaling molecule, exerting diverse effects on skeletal muscle physiology. Due to the apparently positive effects, it would be interesting to consider it as a sports supplement. However, the mechanism behind these effects are yet to be comprehensively understood. In this study, we observed that lactate administration could improve the ability of antifatigue, and we further found that lactate upregulated the expression of myosin heavy chain (MYHC I) and MYHC IIa, while downregulating the expression of MYHC IIb. Besides, transcriptomics and metabolomics revealed significant changes in the metabolic profile of gastrocnemius muscle following lactate administration. Furthermore, lactate enhanced the activities of metabolic enzymes, including HK, LDHB, IDH, SDM, and MDH, and promoted the expression of lactate transport-related proteins MCT1 and CD147, thereby improving the transport and utilization of lactate in both vivo and vitro. More importantly, lactate administration increased cellular Ca2+ concentration and facilitated nuclear translocation of nuclear factor of activated T cells (NFATC1) in myotubes, whereas inhibition of NFATC1 significantly attenuated the effects of lactate treatment on NFATC1 nuclear translocation and MyHC expression. Our results elucidate the ability of lactate to induce metabolic remodeling in skeletal muscle and promote myofiber-type transitions by activating the Ca2+-NFATC1 signaling pathway. This study is useful in exploring the potential of lactate as a nutritional supplement for skeletal muscle adaptation and contributing to a mechanistic understanding of the central role of lactate in exercise physiology.

16.
J Hazard Mater ; 470: 134161, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38569338

RESUMO

BACKGROUND: Exposure to PM2.5 has been linked to neurodegenerative diseases, with limited understanding of constituent-specific contributions. OBJECTIVES: To explore the associations between long-term exposure to PM2.5 constituents and neurodegenerative diseases. METHODS: We recruited 148,274 individuals aged ≥ 60 from four cities in the Pearl River Delta region, China (2020 to 2021). We calculated twenty-year average air pollutant concentrations (PM2.5 mass, black carbon (BC), organic matter (OM), ammonium (NH4+), nitrate (NO3-) and sulfate (SO42-)) at the individuals' home addresses. Neurodegenerative diseases were determined by self-reported doctor-diagnosed Alzheimer's disease (AD) and Parkinson's disease (PD). Generalized linear mixed models were employed to explore associations between pollutants and neurodegenerative disease prevalence. RESULTS: PM2.5 and all five constituents were significantly associated with a higher prevalence of AD and PD. The observed associations generally exhibited a non-linear pattern. For example, compared with the lowest quartile, higher quartiles of BC were associated with greater odds for AD prevalence (i.e., the adjusted odds ratios were 1.81; 95% CI, 1.45-2.27; 1.78; 95% CI, 1.37-2.32; and 1.99; 95% CI, 1.54-2.57 for the second, third, and fourth quartiles, respectively). CONCLUSIONS: Long-term exposure to PM2.5 and its constituents, particularly combustion-related BC, OM, and SO42-, was significantly associated with higher prevalence of AD and PD in Chinese individuals. ENVIRONMENTAL IMPLICATION: PM2.5 is a routinely regulated mixture of multiple hazardous constituents that can lead to diverse adverse health outcomes. However, current evidence on the specific contributions of PM2.5 constituents to health effects is scarce. This study firstly investigated the association between PM2.5 constituents and neurodegenerative diseases in the moderately to highly polluted Pearl River Delta region in China, and identified hazardous constituents within PM2.5 that have significant impacts. This study provides important implications for the development of targeted PM2.5 prevention and control policies to reduce specific hazardous PM2.5 constituents.


Assuntos
Poluentes Atmosféricos , Exposição Ambiental , Material Particulado , Material Particulado/análise , China/epidemiologia , Humanos , Idoso , Poluentes Atmosféricos/análise , Exposição Ambiental/efeitos adversos , Feminino , Masculino , Pessoa de Meia-Idade , Doenças Neurodegenerativas/epidemiologia , Doenças Neurodegenerativas/induzido quimicamente , Doença de Alzheimer/epidemiologia , Doença de Alzheimer/induzido quimicamente , Idoso de 80 Anos ou mais , Doença de Parkinson/epidemiologia , Doença de Parkinson/etiologia , Poluição do Ar/efeitos adversos , Poluição do Ar/análise , Prevalência
17.
Adv Sci (Weinh) ; 11(19): e2306850, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38477543

RESUMO

Micro-Doppler effect is a vital feature of a target that reflects its oscillatory motions apart from bulk motion and provides an important evidence for target recognition with radars. However, establishing the micro-Doppler database poses a great challenge, since plenty of experiments are required to get the micro-Doppler signatures of different targets for the purpose of analyses and interpretations with radars, which are dramatically limited by high cost and time-consuming. Aiming to overcome these limits, a low-cost and powerful simulation platform of the micro-Doppler effects is proposed based on time-domain digital coding metasurface (TDCM). Owing to the outstanding capabilities of TDCM in generating and manipulating nonlinear harmonics during wave-matter interactions, it enables to supply rich and high-precision electromagnetic signals with multiple micro-Doppler frequencies to describe the micro-motions of different objects, which are especially favored for the training of artificial intelligence algorithms in automatic target recognition and benefit a host of applications like imaging and biosensing.

18.
Thorax ; 79(7): 615-623, 2024 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-38388490

RESUMO

BACKGROUND: There is growing interest in the joint effects of hazardous trace elements (HTEs) on lung function deficits, but the data are limited. This is a critical research gap given increased global industrialisation. METHODS: A national cross-sectional study including spirometry was performed among 2112 adults across 11 provinces in China between 2020 and 2021. A total of 27 HTEs were quantified from urine samples. Generalised linear models and quantile-based g-computation were used to explore the individual and joint effects of urinary HTEs on lung function, respectively. RESULTS: Overall, there were negative associations between forced expiratory volume in 1 s (FEV1) and urinary arsenic (As) (z-score coefficient, -0.150; 95% CI, -0.262 to -0.038 per 1 ln-unit increase), barium (Ba) (-0.148, 95% CI: -0.258 to -0.039), cadmium (Cd) (-0.132, 95% CI: -0.236 to -0.028), thallium (Tl) (-0.137, 95% CI: -0.257 to -0.018), strontium (Sr) (-0.147, 95% CI: -0.273 to -0.022) and lead (Pb) (-0.121, 95% CI: -0.219 to -0.023). Similar results were observed for forced vital capacity (FVC) with urinary As, Ba and Pb and FEV1/FVC with titanium (Ti), As, Sr, Cd, Tl and Pb. We found borderline associations between the ln-quartile of joint HTEs and decreased FEV1 (-20 mL, 95% CI: -48 to +8) and FVC (-14 mL, 95% CI: -49 to+2). Ba and Ti were assigned the largest negative weights for FEV1 and FVC within the model, respectively. CONCLUSION: Our study investigating a wide range of HTEs in a highly polluted setting suggests that higher urinary HTE concentrations are associated with lower lung function, especially for emerging Ti and Ba, which need to be monitored or regulated to improve lung health.


Assuntos
Exposição Ambiental , Oligoelementos , Humanos , Estudos Transversais , Masculino , Feminino , Pessoa de Meia-Idade , Exposição Ambiental/efeitos adversos , Exposição Ambiental/análise , China/epidemiologia , Oligoelementos/urina , Adulto , Volume Expiratório Forçado , Espirometria , Capacidade Vital , Pulmão/fisiopatologia , Idoso
19.
Environ Res ; 248: 118305, 2024 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-38307183

RESUMO

Chlorinated polyfluorinated ether sulfonate (F-53B), a substitute of perfluorooctane sulfonic acid (PFOS), has attracted significant attention for its link to hepatotoxicity and enterotoxicity. Nevertheless, the underlying mechanisms of F-53B-induced enterohepatic toxicity remain incompletely understood. This study aimed to explore the role of F-53B exposure on enterohepatic injury based on the gut microbiota, pathological and molecular analysis in mice. Here, we exposed C57BL/6 mice to F-53B (0, 4, 40, and 400 µg/L) for 28 days. Our findings revealed a significant accumulation of F-53B in the liver, followed by small intestines, and feces. In addition, F-53B induced pathological collagen fiber deposition and lipoid degeneration, up-regulated the expression of fatty acid ß-oxidation-related genes (PPARα and PPARγ, etc), while simultaneously down-regulating pro-inflammatory genes (Nlrp3, IL-1ß, and Mcp1) in the liver. Meanwhile, F-53B induced ileal mucosal barrier damage, and an up-regulation of pro-inflammatory genes and mucosal barrier-related genes (Muc1, Muc2, Claudin1, Occludin, Mct1, and ZO-1) in the ileum. Importantly, F-53B distinctly altered gut microbiota compositions by increasing the abundance of Akkermansia and decreasing the abundance of Prevotellaceae_NK3B31_group in the feces. F-53B-altered microbiota compositions were significantly associated with genes related to fatty acid ß-oxidation, inflammation, and mucosal barrier. In summary, our results demonstrate that F-53B is capable of inducing hepatic injury, ileitis, and gut microbiota dysbiosis in mice, and the gut microbiota dysbiosis may play an important role in the F-53B-induced enterohepatic toxicity.


Assuntos
Microbioma Gastrointestinal , Ileíte , Camundongos , Animais , Disbiose , Peixe-Zebra/metabolismo , Camundongos Endogâmicos C57BL , Fígado , Ácidos Graxos/metabolismo
20.
Sci Total Environ ; 921: 171224, 2024 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-38402960

RESUMO

The emissions and exposure limits for airborne PM0.1 are lacking, with limited scientific data for toxicity. Therefore, we continuously monitored and calculated the number and mass concentrations of airborne PM0.1 in December 2017, January 2018 and March 2018 during the high pollution period in Guangzhou. We collected PM0.1 from the same period and analyzed their chemical components. A549, THP-1 and A549/THP-1 co-cultured cells were selected for exposure to PM0.1, and evaluated for toxicological responses. Our aims are to 1) measure and analyze the number and mass concentrations, and chemical components of PM0.1; 2) evaluate and compare PM0.1 toxicity to different airway cells models at different time points. Guangzhou had the highest mass concentration of PM0.1 in December 2017, while the number concentration was the lowest. Chemical components in PM0.1 vary significantly at different time periods, and the correlation between the chemical composition or source of PM0.1 and the mass and number concentration of PM0.1 was dissimilar. Exposure to PM0.1 disrupted cell membranes, impaired mitochondrial function, promoted the expression of inflammatory mediators, and interfered with DNA replication in the cell cycle. The damage caused by exposure to PM0.1 at different times exhibited variations across different types of cells. PM0.1 in March 2018 stimulated co-cultured cells to secrete more inflammatory mediators, and CMA was significantly related to the expression of them. Our study indicates that it is essential to monitor both the mass and number concentrations of PM0.1 throughout all seasons annually, as conventional toxicological experiments and the internal components of PM0.1 may not effectively reveal the health damages caused by elevated number levels of PM0.1.


Assuntos
Poluentes Atmosféricos , Poluição do Ar , Poluentes Atmosféricos/análise , Material Particulado/toxicidade , Material Particulado/análise , China , Mediadores da Inflamação , Tamanho da Partícula , Monitoramento Ambiental
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