RESUMO
Background: During the pandemic and with the growing shortage of nurses, the problem of how to retain existing nurses was of paramount importance. However, there is limited evidence on the relationship between nurses' self-acceptance and intention to stay. Objectives: This study aimed to investigate the factors influencing nurses' intention to stay at work, and explore the relationship between self-acceptance and their intention to stay. Methods: Convenience sampling was conducted to select nurses who worked in a clinical environment during June 2020, in hospitals in Shandong Province, China. Self-designed basic information and two questionnaires, namely, the "self-acceptance questionnaire" and "intention to stay" were adopted. Mean, median, related analysis, and regression analysis were adopted to describe the relationship of self-acceptance and intention to stay on part of Chinese nurses. Results: A total of 1,015 clinical nurses participated in the survey. The mean score of intention to stay among participants was 22.00. The multiple regression analysis revealed various factors, such as age, family support the work, interest in work, job suitability, type of employment, professional level, weekly working hours, working department and self-acceptance influenced the nurse's intention to stay (ß range from -1.506 to 2.249). Conclusion: Our findings identified several factors that are significantly related to and impact the level of intention to stay among clinical nurses.
RESUMO
Depression is one of the major psychiatric diseases affecting the quality of life for individuals worldwide. Numerous reports have investigated depression, although its etiology remains to be elucidated. microRNA (miR)146a is suggested to regulate innate immune and inflammatory responses. However, it is unclear whether miR146a is involved in depression. Depression model mice were established using lipopolysaccharideinduced depression and chronic unpredictable mild stress, separately. miR146a mimic and short interfering RNA were used to treat depressed mice. Depressionlike behaviors and levels of proinflammatory cytokines were measured, while ionized calcium binding adapter molecule 1 (Iba1) expression in hippocampus was quantified by immunohistochemistry. Neuroinflammatory factor levels in hippocampus were measured by western blotting. BV2 cells were used to confirm that miR146a suppressed microglia activation. Compared with control mice, the two depressed mouse models showed clearly decreased sucrose preference and significantly increased immobility time in the forced swimming test and tail suspension test (P<0.05). miR146a overexpression significantly increased sucrose preference and reduced immobility time in depressed mice (P<0.05). However, total distance traveled in the locomotor activity test did not differ among groups. Compared with controls, expression levels of Iba1, inducible nitric oxide, IL1ß, TNFα, interleukin 1 receptor associated kinase 1 (IRAK1), TNF receptorassociated factor 6 (TRAF6) and phosphorylated NFκB p65 were significantly increased in depressed mice (P<0.05). miR146a overexpression effectively inhibited expression of these neuroinflammatory proteins, while miR146a silencing significantly upregulated their expression (P<0.05). Consistent with these in vivo results, miR146a mimic treatment inhibited TNFα, IL1ß, IRAK1 and TRAF6 expression in BV2 cells. miR146a improved depressive behaviors in depressed model mice by inhibiting microglial activation and neuroinflammatory factor expression.