1.
J Org Chem
; 88(13): 8937-8945, 2023 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37339365
RESUMO
The amine-catalyzed [3 + 3] annulations of ß'-acetoxy allenoates with 1C,3N-bisnucleophiles have been established. Under the optimal reaction conditions, this operationally simple synthetic process works well with a wide substrate scope, delivering novel 1,2-fused benzimidazole derivatives in moderate to good yields. In addition, preliminary attempts on the asymmetric version of this reaction have been explored by using cinchona alkaloid-based tertiary amines.