Correction: Direct growth of a porous substrate on high-quality graphene via in situ phase inversion of a polymeric solution.

Correction for 'Direct growth of a porous substrate on high-quality graphene via in situ phase inversion of a polymeric solution' by Yanzhe Qin et al., Nanoscale, 2020, 12, 4953-4958, DOI: 10.1039/C9NR09693K.

Direct growth of a porous substrate on high-quality graphene via in situ phase inversion of a polymeric solution.

The key for graphene applications is the successful transfer of graphene from a growth metal substrate to a substrate for application without compromising its high quality. However, state-of-the-art polymethyl methacrylate (PMMA) assisted transfer methods introduce wrinkles, folds and cracks, which are exacerbated for porous substrates. Here we report a novel in situ technique to transfer graphene onto a porous substrate which resolves these issues. Using phase-inversion a porous substrate is grown onto a graphene film with strong adhesion that perfectly matches graphene's topography, and the growth metal substrate is subsequently etched away. We achieve 63 cm2 high-quality single-layered graphene with almost 100% coverage over the pores of the substrate and pore ratios up to 35%. Our study resolves the three main challenges of transferring graphene to porous substrates, which are matching the topographies between the graphene and the porous substrate, achieving high pore ratios and minimizing the stresses on the suspended graphene; this approach may therefore serve as a general guide for attaching graphene or other 2D materials to scaffold structures.

Synthesis of Biocompatible Cholesteryl-Carboxymethyl Xylan Micelles for Tumor-Targeting Intracellular DOX Delivery.

Patients with cancer suffer from severe side effects and reduced life quality, as chemotherapeutic drugs are cytotoxic toward normal cells as well as toward cancer cells. In recent years, nanoparticles have been explored as targeted drug delivery systems; however, problems such as toxicity and instability prevent their practical application. Here, we report the synthesis of cholesteryl-carboxymethyl xylan (CCMX) via an esterification reaction between the carboxyl group of carboxymethyl xylan and the hydroxyl group of cholesterol to form biocompatible micelles as a vehicle for targeted drugs. With its critical micelle concentration (CMC) depending on the degree of substitution (DS) of cholesteryl and ranging from 0.0024 to 0.017 mg/mL, CCMX could self-assemble and form nanoscale micelles in aqueous media. Taking doxorubicin (DOX) as a model drug, the drug encapsulation efficiency (EE%) of CCMX-3 (DS of 0.35 for cholesteryl) reached 91.3%, and this system exhibited excellent internalization ability, as verified by tumor cellular uptake tests. The results of in vitro cytotoxicity and in vivo antitumor activity tests of nude mice demonstrated that CCMX-3/DOX micelles effectively suppressed the growth of tumor cells by maintaining the cytotoxicity of commercial DOX injection while reducing the toxicity against normal cells and increasing the survival time.

Novel AgNWs-PAN/TPU membrane for point-of-use drinking water electrochemical disinfection.

The safety of drinking water remains a major challenge in developing countries and point-of-use (POU) drinking water treatment device plays an important role in decentralised drinking water safety. In this study, a novel material, i.e. a silver nanowires-polyacrylonitrile/thermoplastic polyurethane (AgNWs-PAN/TPU) composite membrane, was fabricated via electrospinning and vacuum filtration deposition. Morphological and structural characterisation showed that the PAN/TPU fibres had uniform diameters and enhanced mechanical properties. When added to these fibres, the AgNWs formed a highly conductive network with good physical stability and low silver ion leaching (<100 ppb). A POU device equipped with a AgNWs-PAN/TPU membrane displayed complete removal of 105 CFU/mL bacteria, which were inactivated by silver ions released from the AgNWs within 6 h. Furthermore, under a voltage of 1.5 V, the bacteria were completely inactivated within 20-25 min. Inactivation efficiency in 5 mM NaCl solution was higher than those in Na2SO4 and NaNO3 solutions. We concluded that a strong electric field was formed at the AgNW tips. Additionally, silver ions and chlorine compounds worked synergistically in the disinfection process. This study provides a scientific basis for research and development of silver nanocomposite membranes, with high mechanical strength and high conductivity, for POU drinking water disinfection.

Ultrafast Nanofiltration through Large-Area Single-Layered Graphene Membranes.

Perforated single-layered graphene has demonstrated selectivity and flux that is orders of magnitude greater than state-of-the-art polymer membranes. However, only individual graphene sheets with sizes up to tens of micrometers have been successfully fabricated for pressurized permeation studies. Scaling-up and reinforcement of these atomic membranes with minimum cracks and pinholes remains a major hurdle for practical applications. We develop a large-area in situ, phase-inversion casting technique to create 63 cm2 high-quality single-layered perforated graphene membranes for ultrafast nanofiltration that can operate at pressures up to 50 bar. This result demonstrates the feasibility of our technique for creating robust large-area, high quality, single-layered graphene and its potential use as a pressurized nanofiltration membrane.