Study on the Optimization of Matrix Formula of Lanlian Ertong Qingre Cataplasm / 中国药房

OBJECTIVE:To optimize the matrix formula of Lanlian ertong qingre cataplasm. METHODS:Taking adhesion force,peel strength and sensory description as index,the ratio of matrix framework material(sodium polyacrylate-gan hydroxyl alu-minum-tartaric acid-glycerin) was optimized with orthogonal test. The single factor test was adopted to select adhesive and filler;the amount of penetrating agent azone was screened using the in vitro penetration amount of phillyrin. RESULTS:The best matrix ratio of Lanlian ertong qingre cataplasm was sodium polyacrylate-gan hydroxyl aluminum-tartaric acid-glycerin(4.0:0.8:0.4:15);PVP K-90 was used as adhesive,and bolus alba as filler;penetration enhancers azone accounted for 2.0%. Validation test showed, prepared cataplasm had good appearance,could stick on the 5th or the 6th ball;it's peel strength was 7.5 N;all RSDs of score were lower than 4%(n=3). CONCLUSIONS:The optimized matrix formula of Lanlian ertong qingre cataplasm is simple,stable and good in molding.

Struma ovarii:CT findings with corresponding pathological basis / 实用放射学杂志

Objective To study the CT findings of struma ovarii(SO)and improve the understanding of SO imaging features. Methods CT images of 6 cases were retrospectively reviewed.CT plain scan was performed in 6 patients;CT enhancement scan was performed in 2 patients.Results All tumors were unilateral.On non-enhanced CT,the lesions presented as well-defined irregu-lar cystic-solid masses.The cystic portions presented as well-defined,multiple,various size,and there were entire cystic walls with smooth inner wall.Four tumors showed high attenuation lesions in the cyst portion of the mass on precontrast scans.The solid por-tions showed irregular tissue density,and were often distributed in the cysts.The tumors showed stippled calcification in solid por-tions and/or cystic wall in 4 cases.One tumor accompanied a great of ascites liquid.After contrast administration,the cystic por-tions showed no enhancement,and the cystic walls and the solid portions showed mild enhancement.Conclusion CT findings of SO have certain characteristics such as a cystic-solid and well-defined mass with calcification,high attenuation lesion on plain CT,and marked solid part enhancement on contrast CT.

Simulation of the spatial and temporal changes of complex non-point source loads in a lake watershed of central China.

In this study, a coupling model of agricultural and urban non-point source (AUNPS) is established in order to estimate complex non-point source (NPS) pollutant loads in the urban-rural fringe. Furthermore, a spatial-temporal change model of non-point source (CA-AUNPS) is established by the coupling of AUNPS and cellular automata (CA) models. The total nitrogen (TN) and total phosphorus (TP) loads in Tangxun watershed were simulated during 1991-2020, and the results show that: (1) the CA-AUNPS model is an effective tool to simulate the spatial-temporal changes of NPS pollutant loads in urban-rural fringe; (2) in terms of the spatial changes, the TN and TP loads generally showed as rural/urban construction land > farmland > forest/green land, and the high-value areas of NPS pollutant loads expanded from north to south with the increase of construction land; with regard to temporal changes, the TN and TP loads generally displayed an increasing tendency during 1991-2020, and by 2020 the TN and TP loads will increase to 370.06 and 33.89 t yr(-1), respectively; (3) the spatial-temporal changes of TN and TP loads in Tangxun watershed correlate strongly with the land-use, slope, and rainfall.