RESUMO
SARS-CoV-2 is the underlying cause for the COVID-19 pandemic. Like most enveloped RNA viruses, SARS-CoV-2 uses a homotrimeric surface antigen to gain entry into host cells. Here we describe S-Trimer, a native-like trimeric subunit vaccine candidate for COVID-19 based on Trimer-Tag technology. Immunization of S-Trimer with either AS03 (oil-in-water emulsion) or CpG 1018 (TLR9 agonist) plus alum adjuvants induced high-levels of neutralizing antibodies and Th1-biased cellular immune responses in animal models. Moreover, rhesus macaques immunized with adjuvanted S-Trimer were protected from SARS-CoV-2 challenge compared to vehicle controls, based on clinical observations and reduction of viral loads in lungs. Trimer-Tag may be an important new platform technology for scalable production and rapid development of safe and effective subunit vaccines against current and future emerging RNA viruses.
RESUMO
In the event of public health emergencies,information publicity is necessary and important.Currently,China's information publicity system in public health emergencies has achieved a certain success in the building of legal system;however,there are still a lot of constraints,in particular the lack of subjective consciousness of government officials,seriously affecting the implementation of information publicity.Therefore,for further improvement in the information publicity,the driving mechanism should be standardized and specified.
RESUMO
Objective To investigate the protective effects of chitooligosaccharides on chemical hepatic injury induced by carbon tetrachloride(CCl_4) in mice.Methods Liver injury model was established by administration of CCl_4 in mice.The activities of serum alanine aminotransferase(ALT) and aspartate aminotransferase(AST),the content of malondialdehyde(MDA) and the activity of superoxide dismutase(SOD) in hepatic tissue were measured.The hepatic histological changes were observed by optical microscope. Results Chitooligosaccharides(given at 167,500mg?kg~(-1)?d~(-1)for 7 days) remarkably inhibited the rises of serum ALT and AST,and decreased the content of MDA in hepatic tissues in mice,meanwhile increased the activities of SOD in hepatic tissues.Furthermore,the pathological changes were also significantly improved in the mice of treating group.Conclusion Chitooligosaccharides had protective effects on the acute hepatic injury induced by CCl_4 in mice.
RESUMO
The object of medical research is human life,thus the understanding level of human being determines medical mode and the development of medical science.The origin of Marx's theory on human being is the realistic human,which provides methodological basis for reflecting on the biomedical faults from a logical perspective.Marx held that technology is the objectization of the essential power of human being,while technology under the context of capitalist production relations has been turned into certain means to control workers.Tend of dissimilation also arises in some modern medical fields,thus serious reflection and criticism are in great need.The overall development of human being is the core content in Marx's theory on human being.Since modern medicine is during the transition from bio-medical model to bio-psycho-social medial model,the new medical model calls for an overall development of main body in all aspects including qualification,ability,and social relations,etc.
