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Objective To report two cases of familial Gitelman syndrome and literature review regarding the updates of relevant genes,classification,treatment,and prognosis.Methods The clinical data of two sisters with Gitelman syndrome were retrospectively analyzed.Results Their blood pressures were within normal range.Hypokalaemic alkalosis,hypomagnesemia,and hypocalciuria were corrected almost completely after three days of intravenous magnesium and potassium infusion,spirolactone and indometacin.However,the maintenance of normal potassium was unsuccessful over one year.Conclusion Hypokalaemic alkalosis,hypomagnesemia,and hypocalciuria were normalized in Gitelman syndrome.There was some debate in regard to using PGE2 synthetase inhibitors.Tolerance of long-term medication will be the big challenge for curative effect.
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OBJECTIVE To evaluate mortality prediction by analyzing clinical features and pathogens of patients with candidemia in intensive care unit(ICU).METHODS The clinical data of candidemia cases admitted to ICU of the First Affiliated Hospital of Zhejiang University in recent five years were analyzed retrospectively,including risk factors,accompanied diseases,Candida species,drug sensitivity,mortality and prognosis.RESULTS Seventy five cases with candidemia were diagnosed in recent five years.Single factor Logistic regression analysis combined with multiple conditional Logistic regression model analysis was conducted.Compared to other risk factors,indwelling central venous catheter(97.2% vs 74.3%,P=0.043,OR=6.4,95%CI 1.06-38.72),hypoproteinemia(91.7% vs 56.4%,P=0.020,OR=6.01,95%CI 1.33-27.0)and APACHEⅡ score(19.6?3.7 vs 15.0?3.8,P=0.00,OR=1.36,95%CI 1.15-1.62) were markedly different.CONCLUSIONS Candidemia cases in ICU increase gradually and lead to higher mortality.Indwelling central venous catheter,hypoproteinemia and APACHEⅡ score are related to mortality of candidemia cases.
