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1.
Phys Rev Lett ; 121(3): 037001, 2018 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-30085782

RESUMO

Inducing superconductivity in a topological insulator can lead to novel quantum effects. However, experimental approaches to turn a topological insulator into a superconductor are limited. Here, we report on superconductivity in topological insulator Bi_{0.91}Sb_{0.09} induced via focused ion-beam deposition of a Pt thin film. The superconducting phase exhibits a Berezinski-Kosterlitz-Thouless transition, demonstrative of its two-dimensional character. From the in-plane upper critical field measurements, we estimate the superconducting thickness to be ∼17 nm for a 5.5-µm-thick sample. Our results provide evidence that the interface superconductivity could originate from the surface states of Bi_{0.91}Sb_{0.09}.

2.
Clin Exp Rheumatol ; 33(2): 225-33, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25665148

RESUMO

OBJECTIVES: To investigate the expression of glucocorticoid receptor (GR) isoforms in patients with systemic lupus erythematosus (SLE), confirm the main GR isoforms involving in glucocorticoids (GC) resistance, and explore the associations of GR isoforms with serine/arginine-rich protein (SRp) 30c and SRp40. METHODS: Seventy patients with SLE and thirty-eight age- and sex-matched controls were recruited. All patients received prednisone (0.5-1 mg/kg/d) as their routine therapy. According to the therapeutic effect, patients were divided into glucocorticoid-resistant (GCR) and glucocorticoid-sensitive (GCS) groups. Transcript levels of GRα, GRß, GRγ, GR-P, SRp30c and SRp40 in peripheral blood mononuclear cells (PBMCs) were determined by real-time PCR. GRα and GRß proteins were detected by western blotting. Trial registration number is ChiCTR-RCH-12002808. RESULTS: Four GR transcripts in SLE patients showed the following trend: GRα (51.85%) > GR-P (23.78%) > GRγ (13.08%) >GRß (0.03%). GR-P transcript and ratio of GRα/GR-P in SLE patients were significantly higher than that in controls (p<0.05). GRα transcript and protein as well as SRp40 transcript in GCS group were significantly higher than that in the GCR group before GC treatment (p<0.05). In the GCS group, GRα transcript and SRp40 transcript were significantly higher after GC treatment than that before GC treatment (p<0.05). In the GCR group, GR-P transcript was significantly higher after GC treatment than that before GC treatment (p<0.05). Positive correlation between SRp40 and GRα transcript was found (p<0.05). Additionally, SLE Disease Activity Index scores were significantly negatively correlated with GRα transcript and protein expression (p<0.05). CONCLUSIONS: Our data demonstrated that the decreased expression of GRα might be the evidence of high disease activity and help to predict GC resistance. GR-P isoform might be implicated in the development of resistance. Additionally, the preliminary finding suggested that SRp40 might be associated with GRα transcripts in SLE patients.


Assuntos
Leucócitos Mononucleares/metabolismo , Lúpus Eritematoso Sistêmico/sangue , Proteínas Nucleares/sangue , Proteínas de Ligação a RNA/sangue , Receptores de Glucocorticoides/sangue , Adulto , Biomarcadores/sangue , Estudos de Casos e Controles , Resistência a Medicamentos , Feminino , Glucocorticoides/uso terapêutico , Humanos , Leucócitos Mononucleares/efeitos dos fármacos , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Proteínas Nucleares/genética , Valor Preditivo dos Testes , Prednisona/uso terapêutico , Isoformas de Proteínas , RNA Mensageiro/sangue , Proteínas de Ligação a RNA/genética , Receptores de Glucocorticoides/agonistas , Receptores de Glucocorticoides/genética , Fatores de Risco , Fatores de Processamento de Serina-Arginina , Índice de Gravidade de Doença , Fatores de Tempo , Resultado do Tratamento
3.
Nat Commun ; 5: 4673, 2014 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-25146151

RESUMO

Transition metal dichalcogenides [corrected] have attracted much attention recently due to their potential applications in spintronics and photonics because of the indirect to direct band gap transition and the emergence of the spin-valley coupling phenomenon upon moving from the bulk to monolayer limit. Here, we report high-resolution angle-resolved photoemission spectroscopy on MoSe2 single crystals and monolayer films of MoS2 grown on highly ordered pyrolytic graphite substrate. Our experimental results resolve the Fermi surface trigonal warping of bulk MoSe2, and provide evidence for the critically important spin-orbit split valence bands of monolayer MoS2. Moreover, we systematically image the formation of quantum well states on the surfaces of these materials, and present a theoretical model to account for these experimental observations. Our findings provide important insights into future applications of transition metal dichalcogenides in nanoelectronics, spintronics and photonics devices as they critically depend on the spin-orbit physics of these materials.

4.
Phys Rev Lett ; 111(17): 176801, 2013 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-24206511

RESUMO

We report the first direct measurement of transport properties of surface states in the topological insulator Bi(0.91)Sb(0.09) (111) from the weak-field Hall effect and Shubnikov-de Haas oscillations. We find that the holelike surface band displays an unexpectedly high mobility 23,000-85,000 cm(2)/V s, which is the highest mobility so far reported in bismuth-based topological insulators. This result provides the first quantitative assessment of the effect of alloy disorder on the mobility of surface states in topological insulators. We show that the 9% alloy disorder decreases the mobility of surface states by a factor of less than 2.3.

5.
Phys Rev Lett ; 109(24): 246602, 2012 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-23368356

RESUMO

We report the magnetothermopower measurements of the nonmetallic topological insulator Bi(2)Te(3) in magnetic fields up to 35 T. Quantum oscillations arising from surface states are observed in both thermoelectric and conductivity tensors. The inferred surface thermopower has a peak magnitude ~1 mV/K possibly as a result of surface electron and bulk phonon interaction. At the n = 1 Landau level, we resolve additional quantum oscillations signaling Landau sublevels.


Assuntos
Bismuto/química , Magnetismo , Oscilometria/métodos , Teoria Quântica , Telúrio/química , Condutividade Térmica
6.
Science ; 329(5993): 821-4, 2010 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-20671155

RESUMO

Topological insulators are insulating materials that display massless, Dirac-like surface states in which the electrons have only one spin degree of freedom on each surface. These states have been imaged by photoemission, but little information on their transport parameters, for example, mobility, is available. We report the observation of Shubnikov-de Haas oscillations arising from the surface states in nonmetallic crystals of Bi(2)Te(3). In addition, we uncovered a Hall anomaly in weak fields, which enables the surface current to be seen directly. Both experiments yield a surface mobility (9000 to 10,000 centimeter(2) per volt-second) that is substantially higher than in the bulk. The Fermi velocity of 4 x 10(5) meters per second obtained from these transport experiments agrees with angle-resolved photoemission experiments.

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