RESUMO
Two new neolignans, dolominol A (1) and dolominol B (2), together with 12 known lignans, erythro-(7S,8R)-guaiacyl-glycerol-ß-O-4'-dihydroconiferyl ether (3), threo-(7R,â8R)-1-â(4-âhydroxy-â3-âmethoxyphenyl)â-â2-{4-[(E)-â3-âhydroxy-â1-âpropenâyl)â]-â2-âmethoxyphenoxy}-1,â3-âpropanediol (4), (-)-dihydrodehydrodiconiferyl alcohol (5), (-)-massoniresinol (6), vladinol D (7), syringaresinol (8), prinsepiol (9), medioresinol (10), (+)-pinoresinol (11), 2α-guaicyl-4-oxo-6α-catechyl-3,7-dioxabicyclo [3.3.0]octane (12), cycloolivil (13), isolariciresinol (14) were isolated from Dolomiaea souliei (Franch.) C.Shih. Their structures were determined by UV, CD, HR-ESI-TOFMS, 1 D and 2 D NMR experiments. Their hepatoprotective effect against LPS-induced L-02 cells injury was also studied. Result revealed that compound 4 showed best protective effect on LPS-induced L-02 cells.
Assuntos
Asteraceae , Lignanas , Lignanas/química , Lignanas/farmacologia , Lipopolissacarídeos , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
The chemical constituents in the ethyl acetate extract of Corydalis tomentella was isolated and purified with normal and reversed phase silica gel column chromatography, Sephadex LH-20, MCI, and semi-preparative HPLC. The compound structures were identified based on spectroscopic experiments and reported papers. Finally, eighteen compounds(1-18) were obtained from C. tomentella, including 17 alkaloids and 1 terpenoid. Among them, compound 1(tomentellaine A) was a novel alkaloid. Compounds 2-5, 7-14, and 16-18 were isolated from this plant for the first time.
Assuntos
Alcaloides , Corydalis , Cromatografia Líquida de Alta Pressão , Cromatografia de Fase Reversa , Extratos VegetaisRESUMO
One new neolignan glycoside, dolomiside A (1), together with 11 known phenylpropanoid glycosides were isolated from Dolomiaea souliei (Franch.) Shih. The structures of these isolates were determined by UV, CD, HR-ESI-TOFMS, 1D and 2D NMR analysis.
Assuntos
Asteraceae/química , Glicosídeos/isolamento & purificação , Lignanas/isolamento & purificação , Glicosídeos Cardíacos , Medicamentos de Ervas Chinesas/química , Glicosídeos/química , Lignanas/química , Estrutura Molecular , Análise EspectralRESUMO
Seven long-chain amides, including five previously undescribed bacillamidins Aâ»E (1â»5) and two previously reported synthetic analogs, bacillamidins F (6) and G (7), were isolated from extracts of the marine-derived Bacillus pumilus strain RJA1515. The structures of the new compounds were established by extensive analysis of 1D and 2D nuclear magnetic resonance (NMR) data as well as high resolution mass spectrometry (HRMS), and the absolute configurations of the stereogenic carbons of 1â»4 were established by comparison of the calculated and the experimental electronic circular dichroism (ECD) spectra. The cytotoxic and antimicrobial activities of 1â»7 were evaluated.
