RESUMO
We collaborated with researchers from Egypt, Syrian Arab Republic and Jordan in a study of patients with sickle-cell disease from those countries, and from various parts of Saudi Arabia, in order to investigate the influence of genetics on the clinical presentation of the disease, and to attempt to determine the origin of the sickle-cell gene in Arabs. Our results suggest that beta-globin gene haplotypes influence the clinical presentation of sickle-cell disease, and that there are at least two major foci for the origin of the sickle-cell gene, one in the eastern part of Saudi Arabia, and the other in the populations of North Africa and the north-western part of the Arabian peninsula.
Assuntos
Anemia Falciforme/epidemiologia , Anemia Falciforme/genética , Globinas/genética , Haplótipos/genética , Anemia Falciforme/classificação , Egito/epidemiologia , Frequência do Gene , Testes Genéticos , Variação Genética/genética , Heterozigoto , Homozigoto , Jordânia/epidemiologia , Polimorfismo Genético/genética , Vigilância da População , Prognóstico , Características de Residência/estatística & dados numéricos , Mapeamento por Restrição , Arábia Saudita/epidemiologia , Índice de Gravidade de Doença , Síria/epidemiologiaRESUMO
We collaborated with researchers from Egypt, Syrian Arab Republic and Jordan in a study of patients with sickle-cell disease from those countries, and from various parts of Saudi Arabia, in order to investigate the influence of genetics on the clinical presentation of the disease, and to attempt to determine the origin of the sickle-cell gene in Arabs. Our results suggest that beta-globin gene haplotypes influence the clinical presentation of sickle-cell disease, and that there are at least two major foci for the origin of the sickle-cell gene, one in the eastern part of Saudi Arabia, and the other in the populations of North Africa and the north-western part of the Arabian peninsula
