Evaluación del efecto de la ingesta de una sobrecarga de glucosa sobre los niveles séricos de la proteína C reactiva y de la alfa1-antitripsina en mujeres obesas / Effect of a high glucose load on serum concentrations of C-reactive protein and alpha1-antitrypsin in obese women

La obesidad está asociada con un estado inflamatorio. La proteína C reactiva (PCR) es una molécula proinflamatoria y la alfa1-antitripsina es una proteína plasmática sensible a inflamación. El proceso proinflamatorio puede ser influenciado por la hiperglicemia postprandial. Objetivo: Evaluar el efecto de la ingesta de una sobrecarga de glucosa sobre los niveles séricos de PCR y de alfa1-antitripsina en mujeres obesas con tolerancia normal a la glucosa. Metodología: La población estuvo conformada por 15 mujeres obesas (edad = 34,4 ± 4,3 años, IMC = 35,3 ± 5,3 kg/m2) y 15 mujeres normopeso (edad = 33,9 ± 2,9 años, IMC = 21,8 ± 1,9 kg/m2). Los sujetos en ayuno se sometieron a una prueba de tolerancia oral a la glucosa(75 g y 2 h). Se midió los niveles pre y postprandiales de PCR y de alfa1-antitripsina. Los parámetros antropométricos y bioquímicos se midieron en ambos grupos. Resultados: Las mujeres obesas presentaron mayores niveles de PCR en ayuno (P = < 0,001) que las mujeres normo peso. No se observó diferencias en los niveles de alfa1-antitripsina en ayuno en mujeres obesas en comparación con mujeres normopeso (P = 0,26). Los niveles séricos de PCR y alfa1-antitripsina no cambiaron luego de la ingestión de la sobrecarga de glucosa (P > 0,05 diferencia con el nivel preprandial). Los niveles séricos de PCR se correlacionaron positiva-mente con el índice de masa corporal (IMC) en el grupo obeso. Los niveles séricos de alfa1-antitripsina no se correlacionaron con el IMC en ninguno de los dos grupos estudio. Conclusión: La ingesta de una sobrecarga de glucosa no tiene ningún efecto sobre los niveles séricos de PCR y alfa1-antitripsina. Los niveles séricos de alfa1- antitripsina no están incrementados en mujeres obesas. Los niveles séricos de PCR están incrementados en mujeres obesas y se correlacionan positivamente con el IMC

Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and alpha1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. Objective: The aim of the present study was to evaluate the role of high-glucose load on postprandial circulating levels of PCR and alpha1-antitrypsin in obese women with normal glucose tolerance. Design: A total of 15 obese women (age = 34.4 ± 4.3years, BMI = 35.5 ± 5.3 kg/m2) and 15 lean controls women (age = 33.9 ± 2.9 years, BMI = 21.8 ± 1.9 kg/m2) were recruited for this study. After and overnight fast subjects underwent a 2 h-75 g oral glucose tolerance test. Preprandial and postprandial CRP and alpha1-antitrypsin were measured. Anthropometry and blood biochemical parameters were measured in both groups. Results: The obese women had fasting serum PCR levels higher (P = < 0.001) than those of control women. There weren’t differences in fasting serum alpha1-antitrypsin levels in obese group in comparison to lean control group (P = 0.26). Serum PCR and alfa1-antitrypsin did not change postprandially (P = > 0.05 difference to fasting levels). Serum CRP levels was positively related to body mass index (BMI) in obese group. Serum alpha1-antitrypsin was not related to BMI in both groups. Conclusion: A high glucose load is not associated with serum PCR and alpha1-antitrypsin levels increase. Serum alfa1-antitripsin levels are not increased in obese women. Serum PCR levels are increased in obese women, and are positively related to BMI

[Effect of a high glucose load on serum concentrations of C-reactive protein and alpha1-antitrypsin in obese women]. / Evaluación del efecto de la ingesta de una sobrecarga de glucosa sobre los niveles séricos de la proteína C reactiva y de la alpha1-antitripsina en mujeres obesas.

UNLABELLED: Obesity is associated with increased inflammation. C-reactive protein (CRP) is a proinflammatory molecule, and alpha1-antitrypsin is an inflammation-sensitive plasma protein. Proinflammatory process may be influenced by postprandial hyperglycemia. OBJECTIVE: The aim of the present study was to evaluate the role of high-glucose load on postprandial circulating levels of PCR and alpha1-antitrypsin in obese women with normal glucose tolerance. DESIGN: A total of 15 obese women (age=34.4+/-4.3 years, BMI=35.5+/-5.3 kg/m2) and 15 lean controls women (age=33.9+/-2.9 years, BMI=21.8+/-1.9 kg/m2) were recruited for this study. After and overnight fast subjects underwent a 2 h-75 g oral glucose tolerance test. Preprandial and postprandial CRP and alpha1-antitrypsin were measured. Anthropometry and blood biochemical parameters were measured in both groups. RESULTS: The obese women had fasting serum PCR levels higher (P=or<0.001) than those of control women. There weren't differences in fasting serum alpha1-antitrypsin levels in obese group in comparison to lean control group (P=0.26). Serum PCR and alpha1-antitrypsin did not change postprandially (P=or>0.05 difference to fasting levels). Serum CRP levels was positively related to body mass index (BMI) in obese group. Serum alpha1-antitrypsin was not related to BMI in both groups. CONCLUSION: A high glucose load is not associated with serum PCR and alpha1-antitrypsin levels increase. Serum alpha1-antitripsin levels are not increased in obese women. Serum PCR levels are increased in obese women, and are positively related to BMI.