[Pseudodiverticula of the ureter: a precancerous lesion?]. / Pseudodiverticoli dell'uretere: una lesione precancerosa?

Ureteral diverticula belong to the group of acquired diverticula even though their pathogenesis and clinical significance are still debated. They are occasionally detected during urography or retrograde pyelography and appear as small spicular or saccate wall outpouchings, single or more often multiple, mostly limited to the upper third of the ureter. The frequent association of these lesions with transitional cell carcinoma of the urinary tract is a problem of great clinical interest since they might represent a preneoplastic manifestation. The authors report on 16 patients with pseudodiverticula, 6 of whom (37.5%) affected with benign prostatic hyperplasia, 4 (25%) with synchronous or metachronous vesical neoplasm and 3 with renal stones. The remaining three patients were affected respectively with vesicoureteral reflux, neurogenic bladder and ureteropelvic junction obstruction. All patients were men over 46 years old. Ureteral involvement was bilateral in 50% of patients. The radiologic pattern consisted of small marginal outpouchings 1-3 mm in diameter, whose demonstration requires good contrast opacification and ureter distension. Pseudodiverticula were always localized in the upper third of the ureter and were multiple in 15/16 cases. Anatomical-histologic studies showed that pseudodiverticula result from hyperplastic-type proliferation of lung epithelium in the ureteral submucosa. Our observations do not confirm literature data on the frequent association between pseudodiverticula and transitional cell carcinoma because of the common presence, in our patients, of other non-neoplastic urinary conditions. The patients with benign hyperplasia of the ureteral epithelium cannot be excluded to be a risk group for cancer, even though no precise confirmation exists. The best advice is to carefully follow-up the patients with ureteral pseudodiverticula, clinically and with IVP.

[Urography: problems and errors in the diagnosis of renal masses]. / Urografia: problemi ed errori nella diagnostica delle masse renali.

New imaging modalities have gained a prominent role in both detection and diagnosis of kidney disorders. However, excretory urography (IVU) remains the screening examination of choice in everyday diagnostic routine, even though its value in characterising renal masses is poor. The search for more sensitive and less invasive diagnostic modalities has brought about some new dilemmas--e.g., which modality should be performed first when the clinical picture is suggestive of renal tumor, the presence of a malignancy with a negative IVU, small renal tumors as occasional findings--, and has enhanced previous problems,--e.g., technique, administration of i.v. contrast media. After defining the above problems, the authors discuss mistakes in the evaluation and interpretation of urograms. The problems are operator-dependent, or else they may be related to examination technique--e.g., inadequate preparation of the patient, poor image quality--, to the method of examination--e.g., inadequate injection of contrast agents (i.e., type, amount, method of injection)--, to kidney function and, finally, to lesion type. As for lesion type, errors can be related to the detection of the lesion itself--e.g., small renal masses (less than 3 cm phi)--and to lesion definition, due to atypical patterns or to difficult differentiation of tumors from normal findings, from anatomical variants or extrarenal structures.

[Importance of specific prostatic antigen to prostatic volume ratio in the selection of patients for ultrasonography-guided biopsy of the prostate]. / Importanza del rapporto tra antigene prostatico specifico e volume prostatico nella selezione dei pazienti da sottoporre a biopsia ecoguidata della prostata.

US-guided biopsy was performed in 94 patients with suspected lesions at transrectal US. Histology demonstrated carcinoma in 43 cases, benign hyperplasia in 44, and prostatitis in 7. In all cases the prostate specific antigen (PSA) was calculated, by means of US, together with prostatic volume (V). PSA was related to the corresponding gland volume, which resulted in PSA/V index. Subsequently, histology was correlated with both PSA value and PSA/V ratio. Our study showed PSA/V ratio to have higher sensitivity and specificity than absolute PSA value in the diagnosis of prostatic carcinoma. The authors believe prostate US-guided biopsy to be: a) necessary when the suspected area has PSA/V ratio greater than 0.15, and especially when PSA/V greater than 0.30; b) not indicated when echostructural alterations are associated with PSA/V less than 0.15, because they are most frequently due to benign lesions. The combined use of PSA/V ratio and US is therefore suggested to select the patients in whom biopsy is to be performed.

Correlation between prostate-specific antigen and prostate volume, evaluated by transrectal ultrasonography: usefulness in diagnosis of prostate cancer.

The authors calculated the volume of the prostate by transrectal ultrasonography and evaluated prostate-specific antigen (PSA) in 108 patients with benign prostatic disease or with clinically suspected carcinoma and in 35 normal subjects. In each case the PSA value was related to the corresponding gland volume (V), which gives a PSA/V index. 32 patients underwent transurethral resection, 23 underwent open prostatectomy and biopsy was performed in 53. Histological examination revealed benign prostatic hyperplasia in 63, prostatitis in 12 and carcinoma in 33. In normal subjects and in those with benign prostatic diseases, the mean PSA/V index was 0.090 and 0.099, respectively. In patients with prostatic carcinoma the ratio was 1.73. The authors propose that this ratio be used, as an alternative to the absolute value of PSA, to differentiate patients with benign and malignant diseases of the prostate.

[Papillary nephrocarcinoma: radiographic and echographic aspects]. / Nefrocarcinoma papillifero. Aspetti radiografici ed ecografici.

Between 1976 and 1987, 395 patients with kidney tumors were studied with radiological techniques and sonography. In 37 cases (9.4%) histopathology diagnosed pure papillary renal cell carcinoma. Analyzing the radiographic patterns of these neoplasms, the authors observed constantly diminished vascularity (100%), frequent calcifications (35.1%) and necrotic areas (51.3%). Such X-ray features are not specific: nevertheless, their coexistence is strongly suggestive of papillary renal cell cancer. No consistent US pattern was found; however, necrotic areas were easily demonstrated in most cases. It must be stressed how patients with papillary carcinoma experienced a longer postoperative survival; it has not yet been established whether such favorable behavior is due to low biological aggressiveness or to earlier diagnosis.