[Histologic aspects of some organs in the alloxan induced diabetic mouse]. / Aspects histologiques de quelques organes chez un modèle de diabète alloxannique de la souris.

In order to study the modifications in the activity on some CNS drugs by the experimental diabetes, the authors are proposing a model of alloxanic diabetes in the mouse. Diabetes is induced by administering pure alloxan to a well selected brand of mice. Biochemical and histological observations obtained on different vital organs are comparable with those obtained with spontaneously diabetic mice (stable and steady glycemia). This model is consequently a good way of assessing pharmacological comparison.

[Comparative study of antiarrhythmic properties of quinicine versus quinidine (author's transl)]. / Comparaison de deux isomères quinicine et quinidine notamment pour leurs propriétés antidysrythmiques.

Quinicine, an isomer of quinidine is used for its cerebral vasodilating activity. This study was performed in order to find out if quinicine also behaves like an antiarrhythmic agent in animals. The preventive and curative actions of quinicine on the experimental ouabain induced arrhythmia have been demonstrated. The mechanism of action of this drug seems to be the same as quinidine, i.e. prolongation of refractory period, diminution of atrial and atrioventricular conduction velocities, anticholinergic and local anaesthesic properties. The quinuclidic ring is therefore not a major factor to assure the antiarrhythmic activity of quinquina alkaloids.

[Activity of the principal alkaloids of Polyalthia oliveri Engler (Annonaceac) on the central nervous system and the cardiovascular system]. / Activité des principaux alcaloïdes de Polyalthia oliveri Engler (Annonacées) sur le système nerveux central et le systéme cardio-vasculaire

Polyalthia oliveri leaf alkaloid, oliveroline, shows in Mice antiparkinsonian properties which decrease or disappear with the alkaloïds extracted from the bark of the trunk, oliveridine and oliverine. The latter alkaloid has an antihypertensive effect which is not found in oliveridine, only hypotensive by a relaxant close to papaverine action on vascular smooth muscles.

[The properties, especially antispamodic, of total alkaloids of the roots of Xylopia quintasii Engl. and Diels. Annomacea]. / Sur les propriétés, notamment antispasmodiques, des alcaloïdes totaux de racine de Xylopia quintasii Engl et Diels Annonacees

DL50 of the total alkaloids of Xylopia quintasii is 850 mg/kg per os in the mice. Papaverine like properties are described.