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1.
P R Health Sci J ; 41(1): 9-12, 2022 03 17.
Artigo em Inglês | MEDLINE | ID: mdl-35438889

RESUMO

OBJECTIVE: To describe the systemic disease associations and clinical features upon initial presentation of a cohort of patients with type 2 macular telangiectasia who live in Puerto Rico. METHODS: A retrospective review of patients with macular telangiectasia was performed in 4 private retina practices in Puerto Rico. The demographic and clinical characteristics were recorded. RESULTS: Twenty-one patients who were diagnosed with macular telangiectasia were included in the analysis. The median age of presentation was 62 years; 86% were female, and all patients were Hispanics. The median visual acuity at presentation was 20/50. A prior medical diagnosis of type II diabetes mellitus was found in 15 (71.4%) patients, essential hypertension in 12 (57.1%), and dyslipidemia in 9 (42.9%). All patients had bilateral disease. The most common ocular findings were the presence of right-angle vessels in 32 (76.2%) eyes and angiographic hyperfluorescence temporal to the fovea, found in 22 (52.4%) of the affected eyes. One eye had evidence of choroidal neovascularization. CONCLUSION: Our cohort showed a higher prevalence of type 2 diabetes in patients with type 2 macular telangiectasia than in other cohorts. It also supports the findings of other studies showing that macular telangiectasia patients are more likely to have type 2 diabetes and hyperlipidemia. However, the increased prevalence of diabetes and hyperlipidemia may be due to selection bias, and further studies are needed to assess the significance of these findings.


Assuntos
Diabetes Mellitus Tipo 2 , Telangiectasia , Diabetes Mellitus Tipo 2/complicações , Diabetes Mellitus Tipo 2/epidemiologia , Feminino , Angiofluoresceinografia , Humanos , Masculino , Pessoa de Meia-Idade , Porto Rico/epidemiologia , Estudos Retrospectivos , Telangiectasia/diagnóstico , Acuidade Visual
2.
Int J Mol Sci ; 21(1)2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31948078

RESUMO

In this work, we studied the anthracene oxidation by hydroxyl radicals. Hydroxyl radical was generated by reaction of 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin Fe (III) (TPPFe) with hydrogen peroxide under visible radiation at a nitrogen atmosphere. The TPPFe was synthesized by Adler Method followed by metal complexation with Fe (III) chloride hexahydrate. Hydroxyl radical was detected by fluorescence emission spectroscopy and we studied kinetic of anthracene selective oxidation by hydroxyl radicals through the differential method. The TPPFe was characterized by UV-Vis spectrophotometry, Dynamic Light Scattering (DLS) and Scanning Electron Microscopy (SEM) measurements. The results indicated that TPPFE was compound by micro-particles with a size distribution of around 2500 nm. Kinetic results showed that the apparent rate constant for the oxidation of anthracene increased exponentially on as temperature increases, furthermore, the activation energy for the Anthracene oxidation by hydroxyl radicals under visible irradiation was 51.3 kJ/mol. Finally, anthraquinone was the main byproduct generated after oxidation of anthracene by TPP-Fe under visible irradiation.


Assuntos
Antracenos/química , Radical Hidroxila/química , Antracenos/efeitos da radiação , Difusão Dinâmica da Luz , Compostos Férricos/síntese química , Compostos Férricos/química , Peróxido de Hidrogênio/química , Cinética , Luz , Microscopia Eletrônica de Varredura , Nitrogênio , Oxirredução , Porfirinas/síntese química , Porfirinas/química , Porfirinas/efeitos da radiação , Espectrometria de Fluorescência
3.
J Infect Dev Ctries ; 6(1): 58-66, 2012 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-22240430

RESUMO

INTRODUCTION: Lymph node tuberculosis (TB) is the leading cause of extrapulmonary tuberculosis and is the most frequently identified type in Aguascalientes, Mexico. Conventional diagnosis has serious limitations for rapid detection of extrapulmonary tuberculosis in clinical samples. Here PCR and modified FISH have been tested as complementary diagnosis methods for extrapulmonary tuberculosis. METHODOLOGY: The specific insertion sequence IS6110 for Mycobacterium tuberculosis complex was used to perform PCR and build DNA and PNA FISH probes (20bp). PCR and modified DNA and PNA FISH assays were performed to evaluate 41 lymph node paraffin-embedded tissue samples, in comparison with the histopathology diagnosis, which was considered the gold standard (22 positive and 19 negative). RESULTS: In comparison with histopathology diagnosis PCR showed 62.5 % sensitivity and 77.8 % specificity (χ(2) = 4.583 p < 0.05). Modified DNA FISH showed 71.4% sensitivity and 84.6% specificity (χ(2) = 11.21 p < 0.05). PNA FISH showed 66.7% sensitivity and 60.0% specificity (χ(2) = 2.93 p > 0.05). Ziehl Neelsen stain was positive in only four cases of 22 lymph node samples positive to histopathology.  In contrast, PCR and modified DNA FISH were positive in 20 cases of the same group. The negative cases were coincident in all tests. CONCLUSIONS: PCR and DNA FISH showed a significant increase in the number of cases detected and also showed higher sensitivity and specificity compared with data reported by traditional methodology. In developing countries, these techniques could help to complement the early diagnosis and timely treatment of extrapulmonary tuberculosis.


Assuntos
Elementos de DNA Transponíveis/genética , Hibridização in Situ Fluorescente/métodos , Linfonodos/microbiologia , Mycobacterium tuberculosis/isolamento & purificação , Tuberculose dos Linfonodos/diagnóstico , Sondas de DNA , DNA Bacteriano/análise , DNA Bacteriano/genética , Humanos , Linfonodos/patologia , México , Mycobacterium tuberculosis/genética , Inclusão em Parafina , Ácidos Nucleicos Peptídicos/genética , Reação em Cadeia da Polimerase/métodos , Sensibilidade e Especificidade , Tuberculose dos Linfonodos/microbiologia
4.
J Phys Chem B ; 110(39): 19406-11, 2006 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-17004798

RESUMO

We describe the kinetic rates for dye regeneration in dye-sensitized solar cells with organic solid hole conductors, taking as a reference the experimental results of Haque et al. (ChemPhysChem 2003, 4, 89). Our model is based on Marcus rates for electron and hole transfer, emphasizing the Gaussian spread of energy levels in the molecular materials involved. We show that the energy disorder implies a broadening of the efficiency of hole transfer with respect to the thermodynamic driving force, as observed experimentally. The model also shows that tunning of the kinetic processes for high efficiency of energy conversion of the solar cell depends critically on the interplay between the reorganization energy and the broadening parameters of the energy distributions.

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