Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Tipo de estudo
Intervalo de ano de publicação
1.
AIMS Neurosci ; 7(3): 327-332, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32995490

RESUMO

Catatonia commonly refers to a cluster of movement abnormalities, behaviour, volition and speech that has long been associated with psychiatric disorders in adults. Recent evidence suggests increasing prevalence in adolescents and older children with autistic spectrum disorder (ASD), but its occurrence in younger children is rare. Here we describe a 6-year-old boy presenting with catatonic autism, highlighting the diagnostic challenge and demonstrating the importance of timely assessment and management.

2.
Sci Rep ; 6: 21975, 2016 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-26911344

RESUMO

Optimal fetal lung growth requires anion-driven fluid secretion into the lumen of the developing organ. The fetus is hypercalcemic compared to the mother and here we show that in the developing human lung this hypercalcaemia acts on the extracellular calcium-sensing receptor, CaSR, to promote fluid-driven lung expansion through activation of the cystic fibrosis transmembrane conductance regulator, CFTR. Several chloride channels including TMEM16, bestrophin, CFTR, CLCN2 and CLCA1, are also expressed in the developing human fetal lung at gestational stages when CaSR expression is maximal. Measurements of Cl(-)-driven fluid secretion in organ explant cultures show that pharmacological CaSR activation by calcimimetics stimulates lung fluid secretion through CFTR, an effect which in humans, but not mice, was also mimicked by fetal hypercalcemic conditions, demonstrating that the physiological relevance of such a mechanism appears to be species-specific. Calcimimetics promote CFTR opening by activating adenylate cyclase and we show that Ca(2+)-stimulated type I adenylate cyclase is expressed in the developing human lung. Together, these observations suggest that physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR. Disturbances in this process would be expected to permanently impact lung structure and might predispose to certain postnatal respiratory diseases.


Assuntos
Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo , Maturidade dos Órgãos Fetais , Pulmão/embriologia , Pulmão/metabolismo , Organogênese , Receptores de Detecção de Cálcio/metabolismo , Adenilil Ciclases/metabolismo , Animais , Anoctamina-1 , Bestrofinas , Canais de Cloreto/genética , Canais de Cloreto/metabolismo , Regulador de Condutância Transmembrana em Fibrose Cística/genética , Espaço Extracelular , Proteínas do Olho/metabolismo , Feto , Regulação da Expressão Gênica no Desenvolvimento , Humanos , Hipercalcemia/genética , Hipercalcemia/metabolismo , Imuno-Histoquímica , Ativação do Canal Iônico , Canais Iônicos/metabolismo , Camundongos , Modelos Biológicos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...