Recurrent Lower Urinary Tract Infections Have a Detrimental Effect on Patient Quality of Life: a Prospective, Observational Study.

INTRODUCTION: This study investigated the effects of recurrent urinary tract infections (rUTI) and the impact of prophylaxis on rUTI and patients' quality of life (QoL). METHODS: Altogether, 575 patients affected by rUTI were included in a 6-month observational study. QoL was assessed using the Hospital Anxiety and Depression (HAD) and the Leicester scales. Statistical analyses were performed using SAS® Version 8.2 software (SAS Institute Inc., Cary, NC, USA). The significance level was set at 5%. Spearman correlation was used to assess the degree of correlation between infectious episodes and HAD and Leicester scores. For each parameter, the comparison between Day 0 and Day 180 was performed using Wilcoxon signed-rank test for quantitative data. RESULTS: In total, 61.9% of patients suffering from rUTI exhibited some degree of depression at baseline (Day 0). Alternative oral non-antimicrobial prophylactic treatment for rUTI [Escherichia coli lyophilized bacterial lysate (OM-89)] was administered to 94.4% of patients (1 capsule a day for 90 days), followed by a 3-month treatment-free period. At the end of the study (Day 180), the mean number of UTI decreased by 59.3% (P ≤ 0.0001), the total HAD score decreased by 32.1% (P ≤ 0.0001), and the mean Leicester score decreased by 44.0% (P ≤ 0.0001) from baseline. There was a correlation trend between the reduction in the numbers of UTI at the end of the study compared to the 6 months prior to study entry and the reduction in the anxiety, depression, total HAD scores, activity, feeling, and total Leicester scores registered from Day 0 to Day 180, suggesting a lessening of emotional problems, and social and functional handicaps with decreasing UTI incidence. CONCLUSIONS: This study showed that rUTI had a negative impact on patients' QoL and that effective alternative prophylaxis significantly improved their QoL.

Litiasis urinaria en el niño / Urolithiasis in childhood

La litiasis urinaria constituye el 0.2 por ciento de admisiones pediátricas y el 10 por ciento de las admisiones urológicas en el hospital del Niño de Lima, durante los últimos 8 años (1976-1983), cifras alarmantes que indican se le debe considerar como una verdadera zona endémica litogénica. Su incidencia ha aumentado en forma moderada y progresiva. Predominio en el sexo masculino con una relación de 13 a 1, y en el tracto urinario bajo con 74 por ciento de casos. Su tratamiento ha sido eminentemente quirúrgico. Existió paralelismo entre las urolitiasis y, la dieta imbalanceada predominante en cereales y baja en alimentos constructores de tipo proteico y vitaminas