Antibiotic use without prescription in Ecuadorian children according to their families' socioeconomic characteristics / Uso de antibióticos sin prescripción en niños ecuatorianos según las características socioeconómicas de sus familias

AbstrAct background: among the many processes responsible for antimicrobial resistance, inappropriate antibiotic use and self-medication are major public health concerns. To tackle antibiotic resistance and its widespread misuse, is important to identify the social, cultural, and economic differences associated with the problem. Objective: to determine the percentage of antibiotics used without medical prescription in children under five years old with symptoms of upper respiratory tract infection according to their families' socioeconomic characteristics in Ecuador. Materials and Methods: a cross-sectional design was set, using a structured questionnaire to assess mothers who attended urban and rural primary health care units with their children under five years old and belonged to the middle or lower social strata. A sample of 947 individuals was obtained from February to April 2011. Informed consent was acquired from those willing and eligible participants. The descriptive analysis used frequencies, percentages, means, standard deviation and chi-square. Quantitative information was processed using SPSS version 17. Results: those from lower socioeconomic strata used antibiotics to treat symptoms of upper respiratory infections of their children without medical prescription in a higher percentage (35.57%) than middle socioeconomic strata (27.7%, p<0.01). Mothers who had university level education had more knowledge about measures to prevent antibiotic resistance (57.14%) than those with only a primary school education (13.59% p<0.05). Conclusion: antibiotic use in children under five years old with symptoms of upper respiratory infection is high, mainly among those study participants corresponding to lower socioeconomic strata who mostly live in the rural area. MÉD.UIs. 2017;30(2):21-7.

Resumen Introducción: entre los múltiples procesos responsables de la resistencia antimicrobiana, el uso inadecuado de los antibióticos y la automedicación son problemas alarmantes en salud pública. Para la contención de la resistencia a los antibióticos y la ampliación del mal uso, es importante identificar las diferencias sociales, culturales y económicas asociadas al problema. Objetivo: determinar el porcentaje de uso de antibióticos sin prescripción médica en niños menores de cinco años, con síntomas de infección del tracto respiratorio superior de acuerdo las características socioeconómicas de sus familias en Ecuador. Materiales y métodos: se realizó un diseño transversal utilizando un cuestionario estructurado para evaluar a madres pertenecientes a estratos sociales medio y bajo, quienes asistieron con sus hijos menores de cinco años a unidades urbanas y rurales de atención primaria de salud. Se obtuvo desde febrero a abril de 2011, una muestra de 947 individuos que dieron su consentimiento informado. Se hizo un análisis descriptivo mediante el uso de frecuencias, porcentajes, medias, desviación estándar y chi cuadrado. Para el procesamiento de la información cuantitativa se utilizó SPSS versión 17. Resultados: los estratos socioeconómicos más bajos usaron antibióticos sin prescripción médica para tratar síntomas de infecciones respiratorias del tracto respiratorio superior de sus hijos en un mayor porcentaje (35,57%), comparado con los del estrato económico medio (27,7%, p <0.01). Las madres con educación universitaria tuvieron más conocimiento sobre medidas para la prevención de la resistencia bacteriana (57,14%) que aquellas con solamente educación primaria (13,59% p<0,05). Conclusiones: el uso de antibióticos en niños menores de 5 años con síntomas de infección respiratoria alta es elevado, principalmente en aquellos participantes pertenecientes al estrato socioeconómico bajo, quienes viven en su mayoría en el área rural. MÉD.UIs. 2017;30(2):21-7.

Oclusão Percutânea do Apêndice Atrial Esquerdo com Prótese Watchman® / Left Atrial Appendage Closure With the WatchmanTM Device

Introdução: O acidente vascular cerebral secundário à fibrilação atrial tem sido associado a taxas de mortalidade e de incapacidade permanente elevadas, porquanto sua prevenção eficaz é importante. O tratamento com varfarina diminui em 60% o risco de acidente vascular cerebral; todavia, até metade dos pacientes com fibrilação atrial não faz uso da anticoagulação. A oclusão do apêndice atrial esquerdo surgiu como estratégia alternativa para prevenção do acidente vascular cerebral. Métodos: Foram selecionados pacientes com fibrilação atrial, escore de CHA2DS2-VASc ≥ 2, não elegíveis para anticoagulação, para se submeterem ao fechamento percutâneo do apêndice atrial esquerdo com a prótese Watchman®. O procedimento foi realizado sob anestesia geral e guiado por ecocardiografia transesofágica. Resultados: Dos 11 pacientes selecionados, 2 não foram tratados por apresentarem trombo pré ou durante o procedimento, antes do implante do dispositivo. A idade foi de 74 ± 5,1 anos, 66,6% eram do sexo masculino, com escores CHA2DS2-VASc de 4 ± 1,4 e HAS-BLED de 3,4 ± 1,1, 77% tinham contraindicação ou condições sociais desfavoráveis para utilizarem a anticoagulação. O sucesso técnico foi de 100%, sendo alcançada a oclusão completa em todos os casos, com tempo médio de fluoroscopia de 22,1 ± 10,8 minutos e ausência de complicações hospitalares. No seguimento de 78,3 ± 41,5 dias, não ocorreram desfechos clínicos, mas um paciente apresentou trombo no dispositivo e recebeu anticoagulação por 3 meses. Conclusões: A oclusão percutânea do apêndice atrial esquerdo com dispositivo Watchman® é factível e pode ser uma alternativa atrativa na prevenção de acidente vascular cerebral nos pacientes com fibrilação atrial e limitação para anticoagulação.

Background: Stroke secondary to atrial fibrillation has been associated to a high risk of permanent, severe disability, and high early mortality, and therefore its effective prevention is of paramount importance. Warfarin therapy reduces the risk of stroke by 60%, however, half of the patients with atrial fibrillation do not receive anticoagulation. Left atrial appendage closure has emerged as an alternative strategy for stroke prevention. Methods: Patients with atrial fibrillation and CHADSVASc score ≥ 2, not eligible for anticoagulation, were submitted to left atrial appendage closure using the WatchmanTM device. The procedure was performed under general anesthesia and was guided by transesophageal echocardiography. Results: Of the 11 selected patients, 2 were not treated due to thrombi presented prior or during the procedure and before device implantation. Mean age was 74 ± 5.1 years, 66% were male, CHA2DS2-VASc score was 4 ± 1.4, HASBLED score was 3.4 ± 1.1, 77% had contraindications or had unfavorable social conditions for anticoagulation. Technical success was 100% and complete occlusion was obtained in all of the cases, with a mean fluoroscopic time of 22.1 ± 10.8 minutes, and no hospital complications. At a follow-up of 78.3 ± 41.5 days, there were no clinical events but one patient had thrombus formation on the device and received anticoagulation for 3 months. Conclusions: Left atrial appendage closure with the WatchmanTM device is feasible and may be a good alternative therapy for stroke prevention in patients with atrial fibrillation and restrictions for anticoagulation.

Intervenção percutânea em lesão de tronco de coronária esquerda não protegido / Percutaneous coronary intervention for unprotected left main coronary artery lesions

INTRODUÇÃO: Refinamentos da intervenção coronária percutânea (ICP), entre eles a utilização do ultrassom intravascular (IVUS) e da reserva de fluxo fraccionada (FFR), têm permitido o tratamento de lesões complexas com bons resultados. Como consequência, a abordagem percutânea das lesões de TCE se difundiu, incluindo hospitais de menor volume de procedimentos. Nosso objetivo foi apresentar os resultados iniciais e tardios da ICP de lesões de TCE não protegido. MÉTODOS: Foram incluídos pacientes consecutivos tratados em dois centros hospitalares, de agosto do 2009 a julho do 2013. A indicação da estratégia percutânea baseou-se em avaliação clínica, cálculo do escore Syntax, EuroScore e no desejo do paciente. RESULTADOS: Foram tratados 28 pacientes, com idade de 69,2 ± 10,1 anos, 39% eram diabéticos e 39% eram portadores síndrome coronária aguda. Metade dos pacientes tinha EuroScore ≥ 6; o escore Syntax foi de 26,0 ± 8,4 e 82% tinham lesões localizadas na bifurcação. As intervenções foram guiadas por IVUS e/ou FFR em 71,4% dos pacientes, 93% foram tratados com stents farmacológicos, predominantemente pela técnica de 1 stent, e o sucesso angiográfico foi alcançado em 100% dos casos. O acompanhamento foi de 19,2 ± 13,7 meses. A taxa de desfechos clínicos maiores foi de 21,4% no seguimento maior a 4 anos, óbito cardíaco de 14,2%, infarto do miocárdio não fatal de 3,5%, e revascularização da lesão-alvo em 3,5%. CONCLUSÕES: A ICP de TCE não protegido guiada, sempre que possível, por IVUS e/ou FFR é segura e eficaz no curto e longo prazos, na experiência em um hospital com moderado volume de procedimentos.

BACKGROUND: Refinements in percutaneous coronary intervention (PCI), including the use of intravascular ultrasound (IVUS) and fractional flow reserve (FFR), have allowed the treatment of complex lesions with good results. As a result, the percutaneous approach for left main coronary artery (LM) lesions has spread, including centers with a lower volume of PCI procedures. Our objective was to report the early and late outcomes of PCI in unprotected LM lesions. METHODS: Consecutive patients treated at two different hospitals from August 2009 to July 2013 were included. The indication for the percutaneous approach was based on the clinical assessment and the calculation of Syntax score, EuroScore and on the patient's wishes. RESULTS: Twenty-eight patients with mean age of 69.2 ± 10.1 years were treated, 39% were diabetic and 39% had acute coronary syndromes. Half of the patients had EuroScore ≥ 6; the Syntax score was 26.0 ± 8.4 and 82% had LM bifurcation lesions. Interventions were guided by IVUS and/or FFR in 71.4% of the patients, 93% were treated with drug-eluting stents, and the 1-stent technique was used in most occasions. Angiographic success was achieved in 100% of the cases. At the 19.2 ± 13.7 month follow-up, the rate of major adverse cardiac events was 21.4% in the follow-up longer than 4 years, cardiac death 14.2%, non-fatal myocardial infarction 3.5% and target-lesion revascularization 3.5%. CONCLUSIONS: PCI in unprotected LM lesions, guided by IVUS and/or FFR whenever possible, is safe and effective in the short and long-term, in the experience of a hospital with a moderate number of PCI procedures.

Percepciones y prácticas de los escolares sobre las causas, gravedad y tratamiento de las infecciones respiratorias agudas. Azuay, Ecuador, 2012 / School children's perceptions and practices on the causes, gravity and treatment of acute respiratory infection, Azuay, Ecuador, 2012

Objetivo: Identificar las percepciones y prácticas que sobre las causas, gravedad y tratamiento en la infección respiratoria aguda tienen los escolares pertenecientes a distintos estratos sociales de Cuenca en el año 2011. Metodología: Se realizó un estudio descriptivo en una muestra por conveniencia de 498 escolares del sexto y séptimo año de educación básica, de la zona urbana y rural de Azuay. Se explicó a los responsables del cuidado de los escolares el objetivo de la encuesta y se obtuvo el consentimiento informado. Para el control de calidad se realizó un estudio piloto en otra institución diferente a la del estudio. Los datos fueron analizados en el programa SPSS versión 15, se emplearon frecuencias, porcentajes y medidas de tendencia central como promedio y desvío estándar, además se usó el chi cuadrado para buscar significancia estadística. Resultado: La edad promedio fue de 10.8 años para la población urbana y rural, y de conglomerados sociales bajo y medio. Los servicios básicos completos estuvieron presentes en la población de zona urbana en el 83.9% y de conglomerado social medio en 73.8%. El conglomerado social bajo y los escolares de género femenino utilizaban con más frecuencia fármacos en el hogar antes de recibir atención médica (42.3% y 43%). Los escolares del género femenino (41.9%) en mayor porcentaje conocían sobre los antibióticos, mientras que los de género masculino tuvieron mejor conocimiento sobre resistencia bacteriana (26.3%). Los centros de salud y escuelas fueron la principal fuente de información sobre los antibióticos y la resistencia bacteriana, aunque el acceso de los niños a la información en general fue bajo. El nivel de conocimiento de las causas y la gravedad de la infección respiratoria aguda fue inadecuado en un alto porcentaje de los niños y las niñas. La mayoría de los escolares, independientemente de su estado, identificaron que "el cuidado en clima frío" es una medida adecuada de prevención y protección contra IRA, pero muy bajo porcentaje de ellos consideraron reposo, no fumar, alimentación saludable, protección y limpieza nasal como prácticas de autocuidado para prevenir infecciones respiratorias agudas. Conclusiones: Solo un porcentaje limitado de niños y niñas tienen conocimientos y percepciones apropiadas sobre la gravedad de la infección respiratoria aguda, el uso de antibióticos y la resistencia bacteriana. Los programas de contención de la resistencia bacteriana requieren de un enfoque integral y multilateral que involucre a la comunidad con énfasis en la escuela, los niños, las madres y sus familias.

Objective: To identify the perceptions and practices of schoolchildren belonging to different social strata about the causes, severity, and treatment of acute respiratory infection in Azuay province, Ecuador in 2012. Methodology: A descriptive study was conducted in a convenience sample of 498 schoolchildren in the sixth and seventh year of primary school, from both urban and rural areas of Azuay. We talk with the responsible people for the schoolchildren care about the aim of the study, and the informed consent was obtained. For quality control we performed a pilot study in a different institution than this study. Data were analyzed using SPSS version 15, we used frequencies, percentages and measures of central tendency such as middle and standard deviation, and chi-square was used to find statistical significance. Result: The average age of participants was 10.8 years. Children came from both urban and rural regions, and belonged to low or middle social strata. Those of low social strata and of feminine gender more commonly used drugs in the home before receiving medical care (42.3% and 45.0%). A higher percentage of female children (41.9 %) were aware of antibiotics, while the males had better knowledge of bacterial resistance (26.3%). The health-care centers and school were the main source of information on antibiotics and bacterial resistance, although children's access to information overall was low. The level of knowledge of the causes and the severity of acute respiratory infection was inadequate in a high proportion of both boys and girls. The majority of participating schoolchildren, independent of their status identified that "taking care in cold weather" is an appropriate measure of prevention and protection against ARI, but very low percentages of them considered rest, no smoking, healthy food, protection and nasal cleaning as self-care practices to prevent ARI. Conclusions: Only a limited percentage of boys and girls had appropriate knowledge and perceptions about the severity of acute respiratory infection, the use of antibiotics and antibiotic resistance. Programs to contain antibiotic resistance require multilateral and comprehensive approaches that involve the community with an emphasis on the school, children, parents and their families.

Aplicación de la estrategia de Atención Integral de Enfermedades Prevalentes de la Infancia en Ecuador / Implementation of the strategy of Integrated Management of Childhood Illnesses

Introducción: la estrategia de Atención Integral de Enfermedades Prevalentes de la Infancia desarrollada por la Organización Mundial de la Salud y la UNICEF, puede reducir la mortalidad infantil y estimular el uso racional de antibióticos. Objetivo: valorar el cumplimiento de la mencionada estrategia en términos de diagnóstico y tratamiento, en especial el tratamiento con antibióticos, en niños con infección respiratoria aguda en el Ecuador. Métodos: se revisaron las historias clínicas de pacientes que tenían entre dos meses y cinco años de edad, que habían sido atendidos en dos centros de atención primaria de salud en zonas urbanas y rurales, donde los niños reciben atención médica gratuita, entre julio de 2010 y Junio de 2011. Se recolectaron retrospectivamente los datos sobre las características del paciente, diagnóstico y tratamiento. Resultados: en ambos centros de salud y en la mayoría de las historias clínicas se constató la falta de información sobre el tratamiento y la administración de los antibióticos. Se recopilaron los datos de 1 063 pacientes, que revelaron que la prescripción excesiva de antibióticos se produjo con mayor frecuencia (6,50 %) en los centros de atención rural. Conclusiones: hay incumplimiento parcial en la aplicación de la estrategia y es importante en investigaciones futuras profundizar en sus causas. La inaccesibilidad a los servicios de salud podría ser una causa asociada, especialmente en las zonas rurales. La contextualización de la estrategia puede ser necesaria para mejorar la salud infantil, promover el uso racional de los antibióticos y reducir la diseminación de resistencias antimicrobianas.

Introduction: the strategy of Integrated Management of Childhood Illnesses (IMCI) developed by the World health Organization and the UNICEF is aimed at reducing infant mortality and at promoting the rational use of antibiotics. Objective: to evaluate the performance of the above-mentioned strategy for children with acute respiratory infections in Ecuador, in terms of diagnosis and treatment, particularly antibiotic therapy. Methods: the medical histories of patients aged two months to five-years old, who had been diagnosed with ARI and treated at 2 primary health care centers in urban or rural areas in the period of July 2010 through June 2011, were checked. Data about the characteristics of the patients, the diagnosis and the treatment followed were retrospectively collected. Results: in both primary health centers and in most of the medical records, information about the lines of treatment and administration of antibiotics was missing. Data collected on 1 063 patients revealed that over-prescription of antibiotics occurred more frequently in health centers located in rural areas (6.5 %). Conclusion: future research should focus on identifying the causes of failure in the IMCI implementation. The inaccessibility to health centers may be an example of associated causes, especially in rural areas. The contextualization of the IMCI strategy may be needed to improve child health, to promote the rational use of antibiotics and to reduce the spread of antimicrobial resistance.

Avaliação ultrassonográfica intracoronária de imagem angiográfica duvidosa durante intervenção percutânea em bifurcação / Intravascular ultrasound evaluation of equivocal angiographic imaging during percutaneous coronary intervention of bifurcation lesions

O uso do ultrassom intracoronário (USIC) para guiar o implante do stent em bifurcações, especialmente na detecção de complicações relacionadas ao procedimento, tem diminuído as taxas de desfechos clínicos maiores. Neste artigo, reportamos o caso de um paciente submetido a intervenção em bifurcação, em que o fio-guia ultrapassou inadvertidamente por trás das hastes proximais do stent, levando à deformação de sua borda. A complicação foi suspeitada na angiografia e confirmada com o USIC. O USIC foi fundamental no diagnóstico, na confirmação do reposicionamento correto do fio-guia, e na avaliação da ótima expansão e da aposição completa das hastes do stent, prevenindo possível desfecho trombótico precoce e garantindo o resultado a longo prazo.

The use of intravascular ultrasound (IVUS) to guide stent implantation in bifurcation lesions, especially for the detection of procedure-related complications, has decreased the rates of major clinical outcomes. We report a case of a patient undergoing bifurcation intervention, where the guidewire inadvertently was passed behind the proximal stent struts, deforming the stent edge. This complication was suspected at the angiography and was confirmed by IVUS. IVUS was crucial for the diagnosis, to confirm the correct repositioning of the guidewire, and to assess the optimal expansion and complete apposition of stent struts, thus preventing a possible early thrombotic event and ensuring a good long-term outcome.

Ecosystem approach to promoting appropriate antibiotic use for children in indigenous communities in Ecuador / Enfoque ecosistémico de promoción del uso adecuado de antibióticos en niños de comunidades indígenas del Ecuador

Objetivo. Recopilar datos iniciales sobre las enfermedades infecciosas y el uso deantibióticos en dos comunidades indígenas andinas del Ecuador, con el objeto de determinar la factibilidad y la aceptabilidad de aplicar un enfoque ecosistémico para abordar los problemas asociados.Métodos. Mediante visitas a 65 hogares con niños menores de 5 años, se valoraron los factores de riesgo ambientales de las enfermedades infecciosas mediante una evaluación rápida. Se identificaron los conocimientos, las actitudes y las prácticas de los cuidadores relacionados con el uso de antibióticos por medio de una encuesta de conocimientos, prácticas y cobertura; el uso de antibióticos se dedujo a partir de lainspección de los botiquines; y se evaluó el estado general de salud de los 91 niños (incluido su estado de nutrición). Se organizó un taller para transmitir los resultadosy para diseñar una intervención de múltiples componentes basada en un marco ecosistémico de la salud. Resultados. Se encontraron numerosos factores de riesgo ambientales, especialmentelos relacionados con el agua y el saneamiento. El análisis del conocimiento, las actitudes y las prácticas reveló el uso de medicamentos tradicionales y occidentales, y profundas brechas de conocimiento. Había antibióticos en 60,9% de los hogares de Correuco y en 46,8% de La Posta; las tasas de desnutrición eran de 22,2% en Correuco y de 26,1% en La Posta; el mes anterior a la encuesta 26,7% de los niños de Correuco y 47,8% de los niños de La Posta habían tenido episodios de diarrea, con prescripción de antibióticos en 50,0% y 47,1% de los casos, respectivamente; y 28,9% de los niños de Correuco y 47,8% de los niños de La Posta habían tenido infecciones respiratorias agudas, con prescripción de antibióticos en 53,8% y 50,0% de los casos, respectivamente...

Objective. To collect baseline data on infectious diseases and antibiotic use in two Andean indigenous communities in Ecuador in order to determine the feasibility and acceptability of applying an ecosystem approach to address associated problems. Methods. In visits to 65 households with children under age 5 years, environmental risk factors for infectious diseases were evaluated through rapid assessment. Caregivers’knowledge, attitudes, and practices related to antibiotic use were determined through a knowledge, practices, and coverage survey; antibiotic use was gleaned from inspection of medicine chests; and overall health of the 91 children (including nutritional status) wasassessed. A workshop was held to share results and to craft a multicomponent intervention using an ecohealth framework. Results. Numerous environmental risk factors were identified, especially related to waterand sanitation. Knowledge, attitudes, and practices revealed use of traditional and Western medicines and serious knowledge gaps. Antibiotics were present in 60.9% of households inCorreuco and 46.8% in La Posta; malnutrition rates were 22.2% in Correuco and 26.1% in La Posta; diarrheic episodes were experienced in the previous month by 26.7% of children in Correuco and 47.8% in La Posta, with antibiotics prescribed in 50.0% and 47.1% of cases, respectively; and acute respiratory infections were incurred by 28.9% of children in Correuco and 47.8% in La Posta, with antibiotics prescribed in 53.8% and 50.0% of cases, respectively. Conclusions. Environmental, social, and cultural factors must be addressed to preventantibiotic resistance in addition to training health personnel. An ecosystem approach is wellsuited for this goal.

Ecosystem approach to promoting appropriate antibiotic use for children in indigenous communities in Ecuador.

OBJECTIVE: To collect baseline data on infectious diseases and antibiotic use in two Andean indigenous communities in Ecuador in order to determine the feasibility and acceptability of applying an ecosystem approach to address associated problems. METHODS: In visits to 65 households with children under age 5 years, environmental risk factors for infectious diseases were evaluated through rapid assessment. Caregivers' knowledge, attitudes, and practices related to antibiotic use were determined through a knowledge, practices, and coverage survey; antibiotic use was gleaned from inspection of medicine chests; and overall health of the 91 children (including nutritional status) was assessed. A workshop was held to share results and to craft a multicomponent intervention using an ecohealth framework. RESULTS: Numerous environmental risk factors were identified, especially related to water and sanitation. Knowledge, attitudes, and practices revealed use of traditional and Western medicines and serious knowledge gaps. Antibiotics were present in 60.9% of households in Correuco and 46.8% in La Posta; malnutrition rates were 22.2% in Correuco and 26.1% in La Posta; diarrheic episodes were experienced in the previous month by 26.7% of children in Correuco and 47.8% in La Posta, with antibiotics prescribed in 50.0% and 47.1% of cases, respectively; and acute respiratory infections were incurred by 28.9% of children in Correuco and 47.8% in La Posta, with antibiotics prescribed in 53.8% and 50.0% of cases, respectively. CONCLUSIONS: Environmental, social, and cultural factors must be addressed to prevent antibiotic resistance in addition to training health personnel. An ecosystem approach is well-suited for this goal.

Social vaccines to resist and change unhealthy social and economic structures: a useful metaphor for health promotion.

The term 'social vaccine' is designed to encourage the biomedically orientated health sector to recognize the legitimacy of action on the distal social and economic determinants of health. It is proposed as a term to assist the health promotion movement in arguing for a social view of health which is so often counter to medical and popular conceptions of health. The idea of a social vaccine builds on a long tradition in social medicine as well as on a biomedical tradition of preventing illness through vaccines that protect against disease. Social vaccines would be promoted as a means to encourage popular mobilization and advocacy to change the social and economic structural conditions that render people and communities vulnerable to disease. They would facilitate social and political processes that develop popular and political will to protect and promote health through action (especially governments prepared to intervene and regulate to protect community health) on the social and economic determinants. Examples provided for the effects of social vaccines are: restoring land ownership to Indigenous peoples, regulating the advertising of harmful products and progressive taxation for universal social protection. Social vaccines require more research to improve understanding of social and political processes that are likely to improve health equity worldwide. The vaccine metaphor should be helpful in arguing for increased action on the social determinants of health.

Drug-eluting stents vs bare metal stents for the treatment of large coronary vessels

Background Lately drug-eluting stents (DES) have dramatically reduced restenosis rates and need for repeat revascularization in a wide subset of lesion and patients. However, their benefit for the treatment of large vessels (N3.0 mm)

has yet to be established. Objective We investigated whether DES are superior to bare metal stents (BMS) in terms of clinical outcomes for the treatment of large coronary vessels. Methods This study assessed the long-term outcomes (cardiac death, acute myocardial infarction, and need for repeat

intervention in the treated vessel) of patients treated with either a DES (Cypher and Taxus) or a BMS of z3.5 mm in diameter. A total of 250 consecutive patients who underwent DES implantation were clinically followed for 1 year and compared to

250 patients who were treated with BMS. Interventions in the setting of acute ST elevation myocardial infarction and treatment of bypass grafts were excluded. Results Cypher was the DES deployed in 70.8% of cases. Most of the enrolled patients were men (78%) with single

vessel disease (65.6%). The left anterior descending artery was the culprit vessel in 34.2% of cases. Bare metal stent and DES cohorts had equivalent interpolated reference vessel diameter (3.19 F 0.3 mm for BMS vs 3.18 F 0.2 for DES; P = .1).

Lesion was significantly longer in the group treated with DES (13.4 F 5.1 mm for BMS group vs 14.3 F 3.5 for DES; P = .0018). After 1 year of clinical follow-up, 95.2% of patients treated with DES and 91.2% of the patients who received BMS

were free of major events ( P = .2). A trend toward higher target-lesion revascularization was noticed in the group treated with BMS (4.8% vs 1.6%; P = .07). Conclusion Percutaneous treatment of large coronary vessels carries a low risk of clinical events irrespective of the type

Drug-eluting stents vs bare metal stents for the treatment of large coronary vessels

BACKGROUND: Lately drug-eluting stents (DES) have dramatically reduced restenosis rates and need for repeat revascularization in a wide subset of lesion and patients. However, their benefit for the treatment of large vessels (> 3.0 mm) has yet to be established. OBJECTIVE: We investigated whether DES are superior to bare metal stents (BMS) in terms of clinical outcomes for the treatment of large coronary vessels. METHODS: This study assessed the long-term outcomes (cardiac death, acute myocardial infarction, and need for repeat intervention in the treated vessel) of patients treated with either a DES (Cypher and Taxus) or a BMS of > or = 3.5 mm in diameter. A total of 250 consecutive patients who underwent DES implantation were clinically followed for 1 year and compared to 250 patients who were treated with BMS. Interventions in the setting of acute ST elevation myocardial infarction and treatment of bypass grafts were excluded. RESULTS: Cypher was the DES deployed in 70.8% of cases. Most of the enrolled patients were men (78%) with single vessel disease (65.6%). The left anterior descending artery was the culprit vessel in 34.2% of cases. Bare metal stent and DES cohorts had equivalent interpolated reference vessel diameter (3.19 +/- 0.3 mm for BMS vs 3.18 +/- 0.2 for DES; P = .1). Lesion was significantly longer in the group treated with DES (13.4 +/- 5.1 mm for BMS group vs 14.3 +/- 3.5 for DES; P = .0018). After 1 year of clinical follow-up, 95.2% of patients treated with DES and 91.2% of the patients who received BMS were free of major events (P = .2). A trend toward higher target-lesion revascularization was noticed in the group treated with BMS (4.8% vs 1.6%; P = .07). CONCLUSION: Percutaneous treatment of large coronary vessels carries a low risk of clinical events irrespective of the type of stent used.

Drug-eluting stents vs bare metal stents for the treatment of large coronary vessels.

BACKGROUND: Lately drug-eluting stents (DES) have dramatically reduced restenosis rates and need for repeat revascularization in a wide subset of lesion and patients. However, their benefit for the treatment of large vessels (> 3.0 mm) has yet to be established. OBJECTIVE: We investigated whether DES are superior to bare metal stents (BMS) in terms of clinical outcomes for the treatment of large coronary vessels. METHODS: This study assessed the long-term outcomes (cardiac death, acute myocardial infarction, and need for repeat intervention in the treated vessel) of patients treated with either a DES (Cypher and Taxus) or a BMS of > or = 3.5 mm in diameter. A total of 250 consecutive patients who underwent DES implantation were clinically followed for 1 year and compared to 250 patients who were treated with BMS. Interventions in the setting of acute ST elevation myocardial infarction and treatment of bypass grafts were excluded. RESULTS: Cypher was the DES deployed in 70.8% of cases. Most of the enrolled patients were men (78%) with single vessel disease (65.6%). The left anterior descending artery was the culprit vessel in 34.2% of cases. Bare metal stent and DES cohorts had equivalent interpolated reference vessel diameter (3.19 +/- 0.3 mm for BMS vs 3.18 +/- 0.2 for DES; P = .1). Lesion was significantly longer in the group treated with DES (13.4 +/- 5.1 mm for BMS group vs 14.3 +/- 3.5 for DES; P = .0018). After 1 year of clinical follow-up, 95.2% of patients treated with DES and 91.2% of the patients who received BMS were free of major events (P = .2). A trend toward higher target-lesion revascularization was noticed in the group treated with BMS (4.8% vs 1.6%; P = .07). CONCLUSION: Percutaneous treatment of large coronary vessels carries a low risk of clinical events irrespective of the type of stent used.

Implante de múltiplos stents farmacológicos para o tratamento da doença multiarterial em paciente diabética / Use of multiple drug-eluting stents for the treatment of multivessel disease in a diabetic patient

A incidência de diabetes mellitus tem aumentado continuamente nos últimos anos. Os pacientes acometidos por esta enfermidde crônica têm maior risco de desenvolver doença aterosclerótica coronária. Infelizmente, devido ao frequente envolvimento difuso de multiplos vasos, a intervenção percutânea, quer seja com cateter-balçao ou com stent não farmacológico, tem sido associada a pior prognóstico, quando comparada à cirurgia de revascularização miocárdica neste grupo de pacientes. Recentemente, a introdução dos stents farmacológicos renovou o entusiasmo para o tratamento percutâneo de pacientes com lesões mais complexas. Neste artigo, reportamos um caso de uma paciente de 63 anos, portadora de diabetes em uso de insulina, tratada percutaneamente com nove stents farmacológicos (Taxus, Boston Scientific).

The incidence of diabetes mellitus has continuously risen over recent years. Patients with this chronic condition have a higher risk of developing coronary artery disease. Unfortunately, due to the frequent diffuse involvement of multiple vessels, the long term outcomes after percutaneous intervention, whether by balloon catheter or bare-metal stent, has always been poor and frequently inferior to cardiac surgery for this subset of patients. Recently, the introduction of drug-eluting stents (DES) has brought new hope to treat patients with more complex diseases percutaneously. In this paper we report a successful percutaneous approach of a 63-year-old insulin dependent diabetic patient treated with nine DES (TaxusTM, Boston Scientific).

Memorias del II Foro Regional por la Salud Popular: Globalización, Salud y Desarrollo Humano / Memoires of II Regional Forum on Popular Health: Globalization, Health and Human Development

Globalización, salud y desarrollo. La salud bajo la amenaza de la globalización imperialista. La medicalización de la salud. Los nuevos paradigma y la relación con la salud. Asamblea mundial de los pueblos, informe de seguimiento. Declaración de la salud de los pueblos. Proclama de los trabajadores de la salud del Ecuador

Diferencias en la recuperación nutricional de lactantes con distintos cuadros clínicos

Se estudiaron 45 lactantes con desnutrición severa, distribuidos, de acuerdo con la escala de Mclaren en tres grupos: a)Marasmo b)Kwashiorkor y c)Marasmo-Kwashiorkor. Cada grupo estubo constituido por 15 niños de 1 a 24 meses de edad, admitidos para su tratamiento en el departamento de Pediatría del Hospital Regional "Vicente Corral Moscoso" durante el año de 1988. Todos los lactantes que conforman la muestra de estudio recibieron tratamiento dietético mediante alimentación hipercalórica, según protocolo previamente diseñado. Entre los lactantes portadores de Kwashiorkor y aquellos con marasmo o formas mixtas de desnutrición, se constataron diferencias estadisticamente significativas (P<0.01), tanto en el volumen ingerido como en el promedio diario de consumo calórico. Los niños marasmáticos y los portadores de marasmo Kwashiorkor experimentaron un incremento importante de peso y cambios positivos de sus indicadores antropométricos, observándose una asociación estadisticamente significativa entre la ingestión calórica y el incremento ponderal (r = 0.84). En los niños con kwashiorkor se observó ganancia de peso inferior, y el coeficiente de correlación (r) de la regresión lineal no mostró una asociación significativa entre la ingestión calórica y el incremento ponderal. Los autores concluyen que los pacientes marásmicos y los que presentan formas mixtas de desnutricíon severa requieren, para una adecuada recuperación nutricional, de un aporte de calorías mayor que el de aquellos niños afectados por kwasihorkor.

Medicina familiar integral: pago de la deuda social, concertación o mecanismos de legitimización y coerción?

Se analizan los principales aspectos y elementos económico-políticos que sustentan la política de salud del actual régimen y que se expresan en el Plan de Salud Familiar. Se destaca la estrecha relación existente entre los procesos socio-económicos y las condiciones de salud de la población ecuatoriana, señalándose las principales patologías que afectan a las clases y grupos sociales populares. Se realiza una reflexión crítica sobre las líneas de acción fundamentales del nuevo Plan Nacional de Salud. Finalmente, se presenta un análisis somero sobre el papél de la Universidad en la formación de profesionales con elevada capacidad científica y adecuada motivación social que les permita su participación activa en la búsqueda de soluciones integrales a nuestros principales problemas biológicos y sociales.