RESUMO
A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
Assuntos
Antioxidantes/síntese química , Barbitúricos/síntese química , Inibidores Enzimáticos/síntese química , Tiobarbitúricos/síntese química , Antioxidantes/química , Barbitúricos/química , Compostos de Bifenilo/antagonistas & inibidores , Quimotripsina/antagonistas & inibidores , Quimotripsina/química , Ensaios Enzimáticos , Inibidores Enzimáticos/química , Lipoxigenase/química , Picratos/antagonistas & inibidores , Tiobarbitúricos/química , Urease/antagonistas & inibidores , Urease/química , alfa-Glucosidases/químicaRESUMO
In the title compound, C(18)H(17)N(3)O(4), the furyl and phenyl rings are inclined at almost right angles [85.77â (7) and 63.25â (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra-molecular N-Hâ¯O hydrogen bonding.
RESUMO
In the title compound, C(19)H(18)FN(3)O(4), the fused pyridine and pyrimidine rings adopt half-chair conformations. The structure displays intra-molecular N-Hâ¯O and inter-molecular N-Hâ¯F hydrogen bonding.
