Automatic Annotation Tool to Support Supervised Machine Learning for Scaphoid Fracture Detection.

The aim of this work is to develop and validate an automatic annotation tool for the detection and bone localization of scaphoid fractures in radiology reports. To achieve this goal, a rule-based method using a Natural Language Processing (NLP) tool was applied. Finite state automata were constructed to detect, classify and annotate reports. An evaluation of the method on a manually annotated dataset has shown 96,8% of total match.

Hypersialorrhea in Wilson's Disease.

Hypersialorrhea, corresponding to excessive salivation is a symptom frequently reported in Wilson's disease, especially in its neurological form. The prevalence of this frequent complaint has not been often evaluated. During a 7-month period, 87 consecutive Wilson's disease patients answered to the simple question "do you have the sensation of excess saliva in your mouth?" to evaluate the frequency of this symptom. A sub-sample of 10 consecutive Wilson's disease patients with drooling was recruited to undergo quantitative and qualitative measures to evaluate the mechanism of hypersialorrhea. Excessive drooling or excess saliva was found in 46 % of patients followed at the French Reference Centre. Ninety-eight percent of them presented neurological symptoms and drooling was found in only one patient without neurological symptoms. Our study showed that patients with a complaint of excessive saliva produced significantly higher quantities of saliva at rest than controls. Endoscopic examination was abnormal in six patients. A significant decrease of swallowing frequency, longer swallow latencies, and poor swallowing capacities may partly explain the salivary stasis. Oropharyngeal sensitivity disorders were present in 50 % of our patients. The decrease of the swallowing frequency observed in all patients could be related to cognitive and behavioral abnormalities with initiation difficulties objectified by longer latencies triggered by all the ingested volumes. This study confirmed the hypothesis of a multifactorial origin of hypersialorrhea in patients who have been diagnosed in Wilson's disease. It was essential to evaluate drooling with a multidisciplinary consultation to better identify the underlying mechanisms and to implement strategies for speech therapy and therapeutic adaptation.

Objective evaluation of elbow flexion strength and fatigability after nerve transfer in adult traumatic upper brachial plexus injuries.

Nerve transfers Oberlin-type are currently used in upper brachial plexus lesions to recover elbow flexion. Is the regained active motion sufficient to resume heavy manual activities? Five adult patients (mean age 37 years) operated of a nerve transfer to recover elbow flexion (transfer of a motor fascicle of the ulnar nerve to the motor branch of the biceps; in three patients, additional transfer from the median to the motor nerve of the brachialis) were clinically and isokinetically evaluated, after a mean follow-up of 47 months. The median Constant-Murley score was 22/100, the DASH 56/100 and the MEPI 60/100. For isokinetic tests the most significant finding was a severe deficit of elbow strength, of about 80%. No patient was able to maintain an isometric contraction during sufficient time to evaluate fatigability. This preliminary study suggests that major functional impairments persist despite early recovery of elbow flexion. These results should be confirmed in a study on a larger group of patients.

[Wilson disease]. / Maladie de Wilson.

UNLABELLED: Wilson Disease must be considered in very varied circumstances, including in patients older than 50 years. Its diagnosis is not based on a single test but on a group of findings. The copper levels may be difficult to interpret. Molecular biology can confirm the diagnosis in only 80% of cases. The advice of the reference center is necessary before beginning treatment: chelators or zinc salts. Lifetime treatment is required. Follow-up of these patients must be regular and multidisciplinary and should be conducted in association with the reference center. Inclusion in the national registry for Wilson Disease must be suggested to all patients. CONTACT: cmr.wilson@lrb.aphp.fr.

Shoulder arthrodesis using combined internal and external fixation: a review of 9 cases.

A technique of shoulder arthrodesis is presented. Fixation of the arthrodesis combines scapulohumeral half-frame Hoffmann external fixation and internal fixation using a cancellous screw. Cancellous bone autografts are packed at the site of arthrodesis. The functional results of nine cases are presented.

Functional and outcome evaluation of the hand and wrist.

The first evaluation of the upper extremity and hand, performed by the surgeon at the outpatient clinic, is fundamental to understanding the patient's problem, determining the best treatment options, and, in the case of a surgical indication, assessing the preoperative status. In addition to recording the patient's symptoms and complaints, the surgeon evaluates anatomic integrity, stability, mobility, trophicity, strength, and sensibility. In many patients, especially patients with severe handicaps or those who anticipate long delays in rehabilitation, in litigation problems, or as part of prospective clinical research, this classic evaluation is not sufficient. The authors recommend that to accommodate these patients, a laboratory of functional evaluation of the hand should be established. The evaluation, performed by independent reviewers, ideally includes techniques allowing objective measurements of kinematics, strength, sensibility, and global hand function and dexterity. Pain assessment using the VAS is indispensable. The results may be presented as scores based on to the patient's problem. The researchers should analyze precisely how the scores were constructed. Questionnaires are part of the evaluation armamentarium. As with other tools, questionnaires allow us to understand better what our patients experience. They do not replace physical examination. Questionnaires also could be used for routine screening in a general upper limb practice, even before the patient sees the hand surgeon. The choice of the questionnaire is important; the reviewer should make sure that the patient understands all questions, that the questions are not redundant, and that they do apply to the patient. Generic health status instruments such as the SF-36 allow comparison across a variety of health problems, including mental and physical conditions, but are not sensitive to upper extremity disability. The DASH questionnaire seems a better choice, allowing a standardized outcome evaluation. Dedicated questionnaires have been developed for specific conditions (eg, carpal tunnel syndrome). As discussed by Amadio, questionnaires are easier to perform than physical testing, can be self-administered, and require no special equipment, saving the cost of an examiner, avoiding the complexities of scheduling a follow-up examination, and eliminating the possibility of observer bias. The patient is less likely to offer polite but incorrect responses. Questionnaires are especially useful when patient's perceptions are important to assess. Questionnaires also could be used in longitudinal studies to assess improvement or aggravation. The use of questionnaires is therefore especially indicated in studies involving a large number of patients, when observer bias and costs are concerns, and when the main outcome measurements are satisfaction, symptoms, or functional status. Amadio has pointed out that questionnaires are not the best tool to measure anatomic or physiologic impairments.

Nerve granulomas and vasculitis in sarcoid peripheral neuropathy: a clinicopathological study of 11 patients.

Peripheral neuropathy is a rare, yet treatable manifestation of sarcoidosis, a multisystem disorder characterized by the presence of non-caseating granulomas that are seldom found in nerve biopsy specimens. In order to learn more about the subject, we reviewed our clinical and pathological findings in a series of 11 patients (six men and five women aged 26-83 years) with symptomatic neuropathy associated with characteristic granulomas in nerve biopsy specimens. Only two patients were known to have sarcoidosis before the occurrence of the neuropathy. The neuropathy was focal or multifocal in six patients, including one with a multifocal neuropathy associated with conduction blocks, and one with a multifocal axonal motor deficit. Four patients had a distal symmetrical deficit and one patient had a Guillain-Barré-like syndrome with facial diplegia and respiratory failure. Serum angiotensin-converting enzyme concentration was elevated in only two patients. Epineurial granulomas and perineuritis were present in all nerve specimens. The inflammatory infiltrates invaded the endoneurium, following connective tissue septae and blood vessels, in five patients. Multinucleated giant cells were found in eight patients and necrotizing vasculitis in seven. Inflammatory lesions were associated with variable, asymmetrical involvement of nerve fascicles and axon loss. A muscle specimen was sampled during the same procedure in 10 patients. It showed inflammatory infiltrates and granulomas in nine patients and necrotizing vasculitis in two. Immunolabelling showed a mixed inflammatory infiltrate of T cells (predominantly CD4+ cells) and macrophages, in keeping with a delayed hypersensitivity reaction. In addition to nerve involvement, all patients had at least one other tissue or organ affected, including muscle in nine patients, lungs and/or intrathoracic lymph nodes in eight, skin in three, arthritis in two, and peripheral lymph nodes, stomach and eye in one patient each. Most patients improved on corticosteroids. Two patients remain free of symptoms after 7 years. Severe side-effects of long-term treatment with corticosteroids occurred in two patients, leading to death in one. This study illustrates the wide range of clinical manifestations of sarcoid neuropathy and the frequent association of granulomatous inflammatory infiltrates with necrotizing vasculitis and with silent or symptomatic involvement of other organs.