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1.
Sci Rep ; 11(1): 22726, 2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34815447

RESUMO

The present research is designed to examine the dynamic of the quantum computational speed in a nanowire system through the orthogonality speed when three distinct types of magnetic fields are applied: the strong magnetic field, the weak magnetic field, and no magnetic field. Moreover, we investigate the action of the magnetic fields, the spin-orbit coupling, and the system's initial states on the orthogonality speed. The observed results reveal that a substantial correlation between the intensity of the spin-orbit coupling and the dynamics of the orthogonality speed, where the orthogonality speed decreasing as the spin-orbit coupling increases. Furthermore, the initial states of the nanowire system are critical for regulating the speed of transmuting the information and computations.

2.
Pak J Biol Sci ; 16(24): 1849-61, 2013 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-24517000

RESUMO

The present study evaluated the use of 3 types of Cysteine Protease Inhibitors (CPIs) with praziquantel (PZQ) as chemotherapy against schistosomiasis mansoni in mice. All groups were going to assessment of fluromethylketone (FMK), Vinyl Sulfone (VS) and Sodium Nitro Prussid (SNP) by measurement of parasitological, immunological and histological parameters. In our study, The ova count/gm liver or intestine on with PZQ treatment showed 99.1 and 95.2% Percent Reduction (PR), respectively compared to control group. The most effective CPI was FMK when combined with PZQ recording 99.8 and 99.6% PR for liver and intestine, respectively. Regarding to the oogram pattern, FMK, VS and SNP treatment either at 3 or 5 wk PI revealed marked decrease in the immature and mature ova counts and an increase of the dead ova percentages. The effect of CPIs was studied on the PR of Mean Granuloma Diameter (MGD) and Mean Granuloma Number (MGN) of infected treated groups compared to infected control and PZQ treated groups. FMK treatment proved to be highly was effective against S. mansoni in mice disintegrating ova and reduction in granulomatous size and numbers. The microscopic examination of liver sections of infected mice showed a large cellular granuloma with living central ova. sections of Infected mice liver treated with FMK or VS alone or combined with PZQ showed a great reduction in granuloma size as small cellular granuloma with central degenerated ova. We observed that these CPIs alone or combined with PZQ could effectively block schistosomal activity and prevented its growth and differentiation. Briefly, the best schistosomicidal effect of CPIs, that gained by drug administration orally in a dose of 50 mg kg(-1) mouse, was observed with FMK. This was followed by VS and lastly with SNP. These results gave evidence that CPIs can selectively arrest parasite replication without untoward toxicity to the host.


Assuntos
Inibidores de Cisteína Proteinase/farmacologia , Intestinos/efeitos dos fármacos , Fígado/efeitos dos fármacos , Schistosoma mansoni/efeitos dos fármacos , Esquistossomose mansoni/tratamento farmacológico , Esquistossomicidas/farmacologia , Animais , Modelos Animais de Doenças , Granuloma/tratamento farmacológico , Granuloma/parasitologia , Intestinos/parasitologia , Intestinos/patologia , Fígado/parasitologia , Fígado/patologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Nitroprussiato/farmacologia , Contagem de Ovos de Parasitas , Praziquantel/farmacologia , Schistosoma mansoni/crescimento & desenvolvimento , Schistosoma mansoni/imunologia , Esquistossomose mansoni/enzimologia , Esquistossomose mansoni/imunologia , Esquistossomose mansoni/parasitologia , Esquistossomose mansoni/patologia , Sulfonas/farmacologia
3.
J Laryngol Otol ; 103(11): 1059-62, 1989 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-2691598

RESUMO

Bacterial tracheitis is the term used to describe a severe infraglottic infection characterized by toxicity, brassy cough, inspiratory stridor, subglottic oedema and the presence of copious mucopurulent secretions in the trachea. It is an uncommon condition that requires prompt diagnosis and intensive medical therapy if significant morbidity and mortality are to be avoided. Since the condition was first described in 1979 approximately one hundred cases have been reported. In this paper we present four children with bacterial tracheitis to add to the current literature. Interestingly, one child was admitted on two separate occasions with the disease, an event not previously recorded. All patients underwent endoscopy which revealed findings typical of bacterial tracheitis in each case. None required tracheostomy though three required nasotracheal intubation. Post-endoscopy all were managed in the Intensive Care Unit. There were no fatalities or significant morbidity. The average duration of hospitalization was seven days.


Assuntos
Infecções Bacterianas , Traqueíte/etiologia , Infecções Bacterianas/terapia , Criança , Pré-Escolar , Feminino , Humanos , Tempo de Internação , Masculino , Recidiva , Traqueíte/terapia
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