RESUMO
BACKGROUND: Cross-sectional studies have suggested that occupational lead exposure may adversely affect sperm quality. METHODS: Sperm quality changes were prospectively assessed in 19 men employed at a car battery plant where efforts were made to decrease the exposure level. The participants delivered monthly samples of semen and venous blood during their employment at the factory. The factory then closed, and additional samples were obtained from 16 of the men. RESULTS: Average blood-lead concentrations decreased from 2.03 mumol/l to 0.96 mumol/l during the observation period. Concomitantly, significant improvements were seen in the proportion of motile cells both at sample delivery and after 24 hr, and in penetration. However, the sperm cell concentration and the proportion of morphological abnormalities did not change. CONCLUSIONS: These results support the notion that occupational lead exposure at currently acceptable levels has a small adverse effect on sperm quality, especially sperm motility, and that this effect is at least partially reversible.
Assuntos
Infertilidade Masculina/induzido quimicamente , Intoxicação por Chumbo/complicações , Doenças Profissionais/complicações , Sêmen/efeitos dos fármacos , Espermatozoides/efeitos dos fármacos , Adulto , Dinamarca/epidemiologia , Humanos , Infertilidade Masculina/sangue , Infertilidade Masculina/epidemiologia , Intoxicação por Chumbo/sangue , Masculino , Doenças Profissionais/sangue , Doenças Profissionais/epidemiologia , Oligospermia/induzido quimicamente , Oligospermia/epidemiologia , Estudos Prospectivos , Análise de Regressão , Sêmen/citologia , Contagem de Espermatozoides , Espermatozoides/citologia , Fatores de TempoRESUMO
Two cases of infection with multiply resistant Salmonella virchow were probably acquired in Denmark. A 30-year old man and a 20-year old woman had both eaten from the same buffet at a summer restaurant and developed gastrointestinal symptoms and fever after three and six days, respectively. The patients ran a fever for two and five weeks before the admission to the hospital and the woman developed a tuboovarial abscess complicated by peritonitis. S. virchow resistant to ampicillin, streptomycin, tetracycline, and sulfonamide was isolated from faeces in the male patient and from intraabdominal pus in the female patient. Among 35 Danish S. virchow isolates from January 1 to August 31, 1992 there was only one additional multiply resistant isolate (resistant to streptomycin, tetracycline, sulfonamide, and chloramphenicol) the source of which was unknown.
Assuntos
Intoxicação Alimentar por Salmonella/microbiologia , Salmonella/classificação , Adulto , Dinamarca , Resistência Microbiana a Medicamentos , Feminino , Humanos , Masculino , Salmonella/imunologia , Salmonella/isolamento & purificação , Intoxicação Alimentar por Salmonella/tratamento farmacológicoRESUMO
White lead exposure among Danish police officers employed in fingerprint detection. Scand j work environ health 9 (1983) 511-513. White lead is often used by police officers employed in fingerprint detection (dactylography). On the basis of a case of mild lead intoxication in a police officer all 22 exposed police officers at the Bureau of Dactylographic Identification in Copenhagen were examined. All went through a clinical examination and blood lead determination. None of the participants showed any sign of lead intoxication. The median blood lead concentration was 0.97 mumol/l (10th-90th percentiles 0.72-1.44 mumol/l), a value definitely higher than the average of the general population matched for age and sex. A correlation between the weekly white lead exposure and blood lead concentration (r = 0.87, p less than 0.0001) was found among the participants.
