1.
Bioorg Med Chem Lett
; 12(18): 2545-8, 2002 Sep 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12182856
RESUMO
A series of novel phenolic compounds has been discovered as potent inhibitors of TNF-alpha-inducible expression of vascular cell adhesion molecule-1 (VCAM-1) with concurrent antioxidant and lipid-modulating properties. Optimization of these multifunctional agents led to the identification of 3a (AGI-1067) as a clinical candidate with demonstrated efficacies in animal models of atherosclerosis and hyperlipidemia.