[Differences in the cognitive status of patients with schizophrenia depending on the genesis of concomitant encephalopathy]. / Razlichiya kognitivnogo statusa bol'nykh shizofreniei v zavisimosti ot geneza soputstvuyushchei entsefalopatii.

OBJECTIVE: To analyze the cognitive status of patients with schizophrenia and organic cerebral pathology of various genesis. MATERIAL AND METHODS: The study included 75 patients diagnosed with paranoid schizophrenia (F20.0). Depending on the type of organic brain lesion, all patients were divided into four groups: patients with paranoid schizophrenia without organic brain pathology (n=41), patients with dyscirculatory encephalopathy (n=15), patients with post-traumatic encephalopathy (n=12), patients with toxic encephalopathy (n=7).The Brief Assessment of Cognition in Schizophrenia (BACS) and the Rey-Osterrieth Complex Figure (ROCF) followed by the evaluation of the results with the Boston Qualitative Scoring System (BQSS)were used to assess the cognitive status. RESULTS AND CONCLUSION: Patients with schizophrenia without concomitant cerebral pathology had a better state of the cognitive sphere compared to patients whose underlying disease was aggravated by encephalopathy of various genesis. In particular, it applied to such cognitive functions as verbal memory, speech fluency, problem-solving behavior, long-term visual-motor memory, organization and constructive ability. According to the results of this study, patients with posttraumatic encephalopathy had the least pronounced cognitive deficit among patients with an organic brain lesion. In turn, patients with toxic encephalopathy had the worst indicators of the state of the cognitive sphere.

[INFLUENCE OF REAMBERIN® AND CYCLOFERON® ON CONCETRATION OF "AVERAGE MOLECULES" IN SERUM OF PATIENTS WITH RECCURENT DEPRESSIVE DISORDERS IN OUTPATIENT OBSERVATION].

The influence Reamberin® and Cycloferon® concentration "average molecules" in the serum of patients with the recurrent depressive disorders (RDD) was investigated. It was set that the use of these drugs helps to normalize the concentration of "average molecules". which indicates that the elimination of the syndrome of "metabolic" intoxication. Based on the data, we can consider it appropriate inclusion Reamberin® and Cycloferon® in the therapeutic treatment of patients with RDR.

[Interferon status in the treatment of neuroleptic-resistant patients with paranoid schizophrenia].

We studied 73 patients with paranoid schizophrenia with resistance to neuroleptics. All patients were divided into two groups - basic (37 patients) and comparison (36 patients). Both groups received traditional treatment. Patients of the basic group were treated with the combination of reamberin and cycloferon. Before treatment, significant alterations in the interferon status (IFS), which were characterized by the decrease of serum interferon (SIFN) activity and blood α- and γ-interferons (IFN) levels, were identified in both group. The positive effect of the drug combination on clinical symptoms and interferon status (the normalization of SIFN activity, increase in blood α- and γ-IFN levels) was found.

[Efficacy of the combination of cycloferon and reamberin in treatment of resistant patients with paranoid schizophrenia].

The 160 patients with paranoid schizophrenia (PSH) with neuroleptic therapeutic resistance (TR) was investigated. The 90 (basic group) patients got of modern detoxic and metabolically active preparation reamberin and immunotropic facilities cycloferon combination additionally to psychotropic preparations and 70 patients (comparison group) - only the generally accepted therapy. Positive influence of reamberin and cycloferon combination was set on clinical states at the patients of PSH such as disease remission, and endogenous toxicosis syndrome liquidation. Positive influence of this preparations combination was rationed on immunological indexes, characterizing composition and functional activity of cellular immunity.

[The level of lipid peroxidation and the function of the antioxidant system in different forms of schizophrenia]. / Uroven' perekisnogo okisleniia lipidov i sostoianie antioksidantnoi sistemy pri razlichnykh formakh shizofrenii.

Thirty-eight patients diagnosed as having continuous schizophrenia progrediens, 35 patients with shift-like schizophrenia and six patients with hypertoxic (feverish) schizophrenia were studied. The examinees displayed a marked increase in the blood content of lipid peroxidation products, such as malonic dialdehyde and conjugated dienes, together with an enhancement of the degree of erytrocytolysis, which events are particularly noticeable in hypertoxic- and continuous schizophrenia. Blood catalase activity gets higher, that of superoxide dismutase is on the decrease, which facts suggest to us some faults in the system of antioxidant defence.

[The efficacy of enterosorption and a combination of antioxidants in schizophrenics]. / Effektivnost' énterosorbtsii i kompleksa antioksidantov u bol'nykh shizofreniei.

A total of 143 patients with schizophrenia, who ranged from 28 to 42 years old, were studied. Of these, 68 patients were running a continuously progredient course, 75 were in the phase of exacerbation of the attack-like progredient course of schizophrenia. Group I (n = 76) of patients received the enterosorbent polysorb and a complex of antioxidants (tocoferolum acetatum, ascorbic acid, quercetin) as a supplement to the conventional therapy, group II (n = 67) was placed on the conventional therapy only. A complex of the antioxidants as well as the enterosorbent had a positive effect on the clinical course of the condition in 63.2% of group I patients who managed, among other therapeutic benefits, to achieve a stable remission. They have also demonstrated a concomitant improvement or normalization of indices for lipid peroxidation.

[Microhemodynamics and energy metabolism in schizophrenia patients]. / Sostoianie mikrogemodinamiki i énergeticheskogo obmena u bol'nykh shizofreniei.

An apparent disturbance was revealed in microhaemodynamics of patients diagnosed as having schizophrenia (n = 210) which was more pronounced in continuously progredient form of the above medical condition. An increase in conjunctival indexes, polymorphic character of capillaries, decrease in numbers of capillary loops were revealed by biomicroscopy of the bulbar conjunctiva and capillaroscopy respectively. The patients showed lowering of ATP level and rise in the content of cathodic LDG4-LDG5 fractions, accumulation in blood of lactic and pyruvic acids.

[The effect of endovascular laser therapy and antioxidants on the immune status and energy metabolism of patients with treatment-resistant forms of schizophrenia]. / Vliianie éndovaskuliarnoi lazeroterapii i antioksidantov na immunnyi status i énergeticheskii obmen u bol'nykh s resistentnymi k lecheniiu formami shizofrenii.

The influence of endovascular laser therapy and of antioxidants on clinical immunological indices and energy metabolism was analysed in 148 schizophrenic patients including 86 patients with shift-like progredient (first group) and 62 patients with continuous-progredient (second group) forms of the disease. Positive trends in psychosis course were observed in 57% of cases in the first group and in 41.9% of patients of the second group. Pronounced improvement of the immunological indices was observed in patients with positive clinical dynamics: decreased peripheral blood immunocytes sensitization to the brain, hepatic, thymus tissue antigens as well as ATP elevation which was evidence of the improvement of energy metabolism.

[Antioxidants in the treatment of schizophrenia (the correction of lipid peroxidation processes)]. / Antioksidanty v lechenii shizofrenii (korrektsiia protsessov perekisnogo okisleniia lipidov).

It was established in the course of 185 schizophrenic patients' examination that intensification of lipid peroxidation (LP) took place in relapses of the disease. It was manifested either in increase of blood serum levels of both malonic dialdehyde and diene conjugates, or in decrease of erythrocytes' resistance to LP mediated hemolysis. Alterations in indices of either spontaneous or induced chemoluminescence were revealed too. LP indices were lower by the end of the treatment in hospital, but remained significantly higher than normal values. Application of antioxidants in combined treatment of schizophrenic patients promoted decrease of LP activity as well as improvement in mental state of patients. LP activity was high in the remission too. Determination of LP indices may have prognostic importance.

[Immune status and micro-hemodynamic function of patients with chronic alcoholism and liver pathology]. / Immunnyi status i sostianie mikrogemodinamiki bol'nykh khronicheskim alkogolizmom i patologiei pecheni.

126 patients with chronic alcoholism combined with hepatic pathology (of alcoholic genesis) were examined. Laboratory immunological observations with the using of monoclonal antibodies demonstrated the expressed alterations of immune homeostasis exactly the decrease of total T-lymphocytes population (CD11+) as well as the number of T-helpers/inductors (CD40, immunoregulatory index and the increase of the level of circulating immune complexes. The correlation between the immune alterations and the microhemodynamic disturbances was also observed. In connection with the results mentioned above the question arose about application worth of both immunological correctors and angioprotectors in therapy of alcoholism espessially combined with hepatic pathology.