[The spleno-cytotoxic test--an indicator of toxemia in oncologic patients]. / Splenotsitotoksicheskii test--indikator toksemii u onkologicheskikh bol'nykh.

Biologic integral methods for indication of blood toxicity, the migration activity of intact donor leukocytes in agar, and the splenocytotoxic test were used in radiotoxemia assessment in 62 oncologic patients with radiation reactions and in studies on the efficacy of detoxifying therapy with polyvisoline, a new blood substitute, in 25 subjects. Both the methods for studies of the blood serum toxicity were found sufficiently informative and unsophisticated, but the splenocytotoxic test proved to be more sensitive, simple, and rapid.

[Morphofunctional changes in the immune system during reparative regeneration of the liver]. / Morfofunktsional'nye izmeneniia immunnoi sistemy v protsesse reparativnoi regeneratsii pecheni.

A rise of the functional activity of the immune system was noted during reparative processes in the liver Resection of the liver was accompanied by sharp changes in the thymus and spleen structure. The thymus-dependent parts of the spleen were particularly reactive. Resection of the liver in rats was accompanied by an elevation in the bone marrow of the stem cell count (determined by the splenic colony method). The number of the colony-forming cells was significantly greater in the spleen of the recipients of lymphoid cells taken from the operated animals than in the spleen of the recipients of lymphoid cells from intact rats. In screening the limb the capacity to form endogenous colonies proved to be greater in partially hepatectomized rats as compared to the unoperated animals. In rabbits resection of the liver was accompanied by a significant increase of the immunological reactivity on the 1st-3rd postoperative days. Leukergia and leukocytolysis reaction displayed a marked intensification at this period.