Strain Rate-Dependent Compressive Properties of Bulk Cylindrical 3D-Printed Samples from 316L Stainless Steel.

The main aim of the study was to analyse the strain rate sensitivity of the compressive deformation response in bulk 3D-printed samples from 316L stainless steel according to the printing orientation. The laser powder bed fusion (LPBF) method of metal additive manufacturing was utilised for the production of the samples with three different printing orientations: 0∘, 45∘, and 90∘. The specimens were experimentally investigated during uni-axial quasi-static and dynamic loading. A split Hopkinson pressure bar (SHPB) apparatus was used for the dynamic experiments. The experiments were observed using a high-resolution (quasi-static loading) or a high-speed visible-light camera and a high-speed thermographic camera (dynamic loading) to allow for the quantitative and qualitative analysis of the deformation processes. Digital image correlation (DIC) software was used for the evaluation of displacement fields. To assess the deformation behaviour of the 3D-printed bulk samples and strain rate related properties, an analysis of the true stress-true strain diagrams from quasi-static and dynamic experiments as well as the thermograms captured during the dynamic loading was performed. The results revealed a strong strain rate effect on the mechanical response of the investigated material. Furthermore, a dependency of the strain-rate sensitivity on the printing orientation was identified.

A Method for Evaluation the Fatigue Microcrack Propagation in Human Cortical Bone Using Differential X-ray Computed Tomography.

Fatigue initiation and the propagation of microcracks in a cortical bone is an initial phase of damage development that may ultimately lead to the formation of macroscopic fractures and failure of the bone. In this work, a time-resolved high-resolution X-ray micro-computed tomography (CT) was performed to investigate the system of microcracks in a bone sample loaded by a simulated gait cycle. A low-cycle (1000 cycles) fatigue loading in compression with a 900 N peak amplitude and a 0.4 Hz frequency simulating the slow walk for the initialization of the internal damage of the bone was used. An in-house developed laboratory X-ray micro-CT imaging system coupled with a compact loading device were employed for the in situ uni-axial fatigue experiments reaching a µ2µm effective voxel size. To reach a comparable quality of the reconstructed 3D images with the SEM microscopy, projection-level corrections and focal spot drift correction were performed prior to the digital volume correlation and evaluation using differential tomography for the identification of the individual microcracks in the microstructure. The microcracks in the intact bone, the crack formation after loading, and the changes in the topology of the microcracks were identified on a volumetric basis in the microstructure of the bone.

In-situ X-ray Differential Micro-tomography for Investigation of Water-weakening in Quasi-brittle Materials Subjected to Four-point Bending.

Several methods, including X-ray radiography, have been developed for the investigation of the characteristics of water-saturated quasi-brittle materials. Here, the water content is one of the most important factors influencing their strength and fracture properties, in particular, as regards to porous building materials. However, the research concentrated on the three-dimensional fracture propagation characteristics is still significantly limited due to the problems encountered with the instrumentation requirements and the size effect. In this paper, we study the influence of the water content in a natural quasi-brittle material on its mechanical characteristics and fracture development during in-situ four-point bending by employing high-resolution X-ray differential micro-tomography. The cylindrical samples with a chevron notch were loaded using an in-house designed four-point bending loading device with the vertical orientation of the sample. The in-house designed modular micro-CT scanner was used for the visualisation of the specimen's behaviour during the loading experiments. Several tomographic scans were performed throughout the force-displacement diagrams of the samples. The reconstructed 3D images were processed using an in-house developed differential tomography and digital volume correlation algorithms. The apparent reduction in the ultimate strength was observed due to the moisture content. The crack growth process in the water-saturated specimens was identified to be different in comparison with the dry specimens.

Physicochemical pharmacokinetics as an optimization tool for generic development: A case study.

In spite of the fact that dissolution time profiles of 250mg ursodeoxycholic acid (UCDA) capsules developed by Sponsor and 250mg hard capsules produced by Ursofalk®, Dr. Falk Pharma GmbH, indicated similarity (f2=60.6), a bioavailability study indicated unexpected differences in the formulations. To find an explanation of the in vivo performance of the compared formulations, the dissolution profiles were analyzed using a novel dissolution theory considering: The dissolution model was applied to the measured data using SADAPT. Despite Cmax and AUC values showing higher values after administration of the test product, a reduction of UDCA particle size for the test formulation was suggested for reformulation. The decision was based on the strongly pH-dependent UDCA solubility, formation of insoluble crystals at low pH condition and the known high pH fluctuations ranging from pH1 to 8 in empty stomach. The performed reformulation led to increased dissolution rate of the test product and to a positive bioequivalence study which compared the reformulated test generic formulation with two reference products purchased from two highly regulated markets.