[Characteristics of the occurrence of hematotoxic side effects of cytostatic drugs--results of a retrospective 10 year study of a district hospital]. / Charakteristika des Auftretens hämatotoxischer Nebenwirkungen von Zytostatika--Ergebnisse einer retrospektiven Zehnjahresstudie eines Kreiskrankenhauses.

From 1978 to 1988 in 77 patients of a district hospital, 58 females and 19 males, with malignant tumours or haemoblastoses a therapy with cytostatic agents was finished. A retrospective study analyses characteristics of haematotoxic side effects of cytostatic agents, which despite usual dosage according to the valid guide-lines have appeared in this patient population. According to this the granulocytopoiesis is injured most frequently and most severely. In one third of all patients under influence of cytostatic agents the number of the segment-nuclear granulocytes in the peripheral blood decreased deeper than 0.5 Gpt/l (severe neutropenia). In toxic influences on the thrombopoiesis slight and medium degrees of severity are dominating. Lesions of the erythropoiesis are apparently more infrequent, though they are more difficult to be proved. Further characteristics in the occurrence of severe neutropenias (date, dependence on age, pharmacological aspects) are demonstrated and discussed.

[Severe neutropenia following cytostatic drug therapy--clinical symptoms, follow-up and prognosis in 26 patients of a district hospital]. / Schwere Neutropenie nach Zytostatikatherapie--klinische Symptomatik, Verlauf und Prognose bei 26 Patienten eines Kreiskrankenhauses.

The clinical courses of 26 patients with severe neutropenia after application of cytostatic agents are demonstrated. The symptomatology reaches from complete freedom of complaints to severe and most severe clinical appearances. In all 7 asymptomatic patients a complete remission of the changes of the blood picture occurred. Patients with lacking or partial remission of the blood picture after severe neutropenia induced by cytostatic agents have in general a bad prognosis quoad vitam. Infections are the most important complication of a severe neutropenia. Conclusions for the clinical practice concerning the prophylaxis and the early recognition of severe neutropenias as well as of neutropenic complications are derived. Irreversible lesions of the bone marrow by cytostatic agents are notifiable unwished effects of drugs.

[Primary malignant teratoma of the spleen]. / Primäres malignes Teratom der Milz.

It is reported on the unusually rare case of a primary malignant teratoma of the spleen. Course of diagnosis and therapy are discussed.

[Alcohol-induced hypertension]. / Alkoholinduzierte Hypertonie.

The frequency of hypertension in a group of alcoholics and the incidence of alcohol abuse in a group of patients with hypertension was compared with a collective with type-II-diabetes. There is a high relationship between alcoholics and hypertension, a lower one between alcohol abuse in the hypertension group. Chronic alcohol abuse seems to be a more important risk factor for the development of hypertension than diabetes. Genesis and therapeutic consequences of alcohol-induced hypertension are discussed.

[Alcohol-induced cardiomyopathy]. / Beitrag zur alkoholtoxischen Kardiomyopathie.

Because of increasing alcoholism the importance of alcoholic organ lesions is also increasing. The alcoholic cardiomyopathy, which is the result of toxicity of alcohol, but also of alcohol-induced hypertension, coronary sclerosis and toxic destroyed nervous system, is demonstrated with a the keep of case. Stages, diagnosis, therapy and prognosis are described. The most important consequence is abstinence.

[Acute cerebrovascular disease in patients of employable age-- results of a staged therapy program]. / Die akute zerebrovaskuläre Erkrankung bei Patienten im arbeitsfähigen Alter--Ergebnisse eines Stufentherapieprogramms.

The authors take position to distribution of age, sex and stadium, risk factors and therapeutic possibilities in 85 patients with cerebrovascular disease under 65 years. 80 percent have had hypertension, 34 percent diabetes and 15 percent had overweight. Ischemic forms of CVI prevailed with 62 percent. Within the stadia the age distribution is equal. In Stadium II and III mortality is small independent of age. The therapeutic success seems to be independent of therapeutic program. In stadium IV an oncoosmotic and brain metabolism promoting program seems to be superior to an only oncoosmotic acting. An ordered therapy-program after CVI-stadia is proposed.