RESUMO
In the mice of the high leukemic strain, sick with natural lymphatic leukemia, the following parameters were determined on the 0 day, after 90, 180 and 270 days of observation: activity of the superoxide dismutase (SOD-EC1.15.1.1), glutathione peroxidase (GSH-px-EC1.11.1.9) in the blood and catalase activity in erythrocytes. It was observed that the activity of all three enzymes during the development of the leukemic process decreased. This phenomenon indicates the disturbance of the protective role of these enzymes against free radicals in leucogenesis in mice.
Assuntos
Catalase/sangue , Glutationa Peroxidase/sangue , Leucemia Experimental/enzimologia , Leucemia de Células T/enzimologia , Superóxido Dismutase/sangue , Animais , Eritrócitos/enzimologia , Feminino , CamundongosRESUMO
The hens were given per os every second day for the period of 6 weeks selenium in the amount of 0.2 mg/l water (group I), 1.4 mg (group II), copper in amount of 1000 mg/kg feed (group III) and both metals jointly (group IV)--0.2 mg Se and 1000 mg Cu and group V--1.4 mg Se and 1000 mg Cu. Histopathological studies on hens organs and accumulation of metals in tissue were carried out. It was found that selenium in the amount of 1.4 mg/l water causes insignificant oedema of liver and kidneys, whereas copper (group III) shows clear hepato- and nephropathic effect. Selenium administered jointly with copper (group V) acts protectively in parenchymatous organs against the toxic effect of copper alone.