1.
Org Lett
; 16(2): 476-9, 2014 Jan 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24350760
RESUMO
The first asymmetric silylation of unsaturated lactams and amides using Cu(I)-NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
2.
Chem Commun (Camb)
; 49(45): 5150-2, 2013 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23629548
RESUMO
The scope of the asymmetric silyl transfer to unsaturated lactones utilising a C2-symmetric NHC-Cu(I) catalyst has been established and kinetic resolutions mediated by silyl transfer have been used to prepare enantiomerically enriched anti-4,5-disubstituted 5-membered lactones. The method has been exploited in an expedient synthesis of (+)-blastmycinone.