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1.
J Hazard Mater ; 471: 134277, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38657505

RESUMO

This study investigates the presence of biocides and other semi-volatile organic compounds (SVOCs) in cleaning products used in daycare centers and health impact through ingestion of settled dust by young children. In Paris metropolitan area, 106 daycares area were investigated between 2019-2022. Fifteen substances were analyzed in settled indoor dust by gas chromatography-tandem mass spectrometry. Detection rates and concentrations ranged from 5 to 100%, and

Assuntos
Poluição do Ar em Ambientes Fechados , Creches , Desinfetantes , Poeira , Compostos Orgânicos Voláteis , Poeira/análise , Humanos , Compostos Orgânicos Voláteis/análise , Poluição do Ar em Ambientes Fechados/análise , Desinfetantes/análise , Lactente , Saúde Pública , Monitoramento Ambiental , Pré-Escolar
2.
J Hazard Mater ; 446: 130654, 2023 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-36608580

RESUMO

The widespread application of glyphosate leads to significant contamination of outdoor environmental compartments, notably air and soil, which can contaminate indoor air and dust. This study assessed the contamination of indoor household dust for the first time in France and potential exposure to glyphosate through the inadvertent ingestion of dust. A specific and new analytical method was developed using HILIC MS/MS (hydrophilic interaction liquid chromatography with tandem mass spectrometry) to measure polar pesticides, such as glyphosate, aminomethylphosphonic acid, and glufosinate, in indoor dust, with a low quantification limit (25 ng/g). The dust from vacuum cleaner bags of 60 rural and urban households (Brittany, France) was analyzed. All samples contained glyphosate (median 1675 ng/g for rural dwellings (n = 29), 457 ng/g for urban dwellings (n = 31)), more than 90 % contained aminomethylphosphonic acid, and none contained glufosinate. Concentrations were influenced by the rural or urban setting, the proximity of crops, and the use of weed killers on driveways or lawns. Glyphosate exposure via indoor dust ingestion was < 1 % of both acceptable daily intake and dietary intake. However, the high quantification limit of the glyphosate concentration in the food analysis method probably leads to overestimation of the dose from food.


Assuntos
Poeira , Espectrometria de Massas em Tandem , Humanos , Espectrometria de Massas em Tandem/métodos , Ácido alfa-Amino-3-hidroxi-5-metil-4-isoxazol Propiônico , Poeira/análise , Cromatografia Líquida/métodos , Interações Hidrofóbicas e Hidrofílicas , Glifosato
3.
J Hazard Mater ; 352: 215-227, 2018 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-29621676

RESUMO

Many semi-volatile organic compounds (SVOCs), suspected of reprotoxic, neurotoxic or carcinogenic effects, were measured in indoor settled dust. Dust ingestion is a non-negligible pathway of exposure to some of these SVOCs, and an accurate knowledge of the real exposure is necessary for a better evaluation of health risks. To this end, the bioaccessibility of SVOCs in dust needs to be considered. In the present work, bioaccessibility measurement methods, SVOCs' oral bioaccessibility data and influencing factors were reviewed. SVOC bioaccessibilities (%) ranged from 11 to 94, 8 to 100, 3 to 92, 1 to 81, 6 to 52, and 2 to 17, for brominated flame retardants, organophosphorus flame retardants, polychlorobiphenyls, phthalates, pesticides and polycyclic aromatic hydrocarbons, respectively. Measurements method produced varying results depending on the inclusion of food and/or sink in the model. Characteristics of dust, e.g., organic matter content and particle size, also influenced bioaccessibility data. Last, results were influenced by SVOC properties, such as octanol/water partition coefficient and migration pathway into dust. Factors related to dust and SVOCs could be used in prediction models. To this end, more bioaccessibility studies covering more substances should be performed, using methods that are harmonized and validated by comparison to in-vivo studies.


Assuntos
Poluição do Ar em Ambientes Fechados/análise , Poeira/análise , Contaminação de Alimentos/análise , Compostos Orgânicos Voláteis/análise , Disponibilidade Biológica , Ingestão de Alimentos , Monitoramento Ambiental/métodos , Humanos
4.
Environ Int ; 113: 202-213, 2018 04.
Artigo em Inglês | MEDLINE | ID: mdl-29448239

RESUMO

Semi-volatile organic compounds (SVOCs) present in indoor environments are known to cause adverse health effects through multiple routes of exposure. To assess the aggregate exposure, the bioaccessibility and bioavailability of SVOCs need to be determined. In this review, we discussed measurements of the bioaccessibility and bioavailability of SVOCs after inhalation. Published literature related to this issue is available for 2,3,7,8-tetrachlorodibenzo-p-dioxin and a few polycyclic aromatic hydrocarbons, such as benzo[a]pyrene and phenanthrene. Then, we reviewed common modeling approaches for the characterization of the gas- and particle-phase partitioning of SVOCs during inhalation. The models are based on mass transfer mechanisms as well as the structure of the respiratory system, using common computational techniques, such as computational fluid dynamics. However, the existing models are restricted to special conditions and cannot predict SVOC bioaccessibility and bioavailability in the whole respiratory system. The present review notes two main challenges for the estimation of SVOC bioaccessibility and bioavailability via inhalation in humans. First, in vitro and in vivo methods need to be developed and validated for a wide range of SVOCs. The in vitro methods should be validated with in vivo tests to evaluate human exposures to SVOCs in airborne particles. Second, modeling approaches for SVOCs need to consider the whole respiratory system. Alterations of the respiratory cycle period and human biological variability may be considered in future studies.


Assuntos
Poluentes Atmosféricos/farmacocinética , Exposição por Inalação , Hidrocarbonetos Policíclicos Aromáticos/farmacocinética , Compostos Orgânicos Voláteis/farmacocinética , Poluição do Ar em Ambientes Fechados , Animais , Disponibilidade Biológica , Humanos , Modelos Biológicos , Dibenzodioxinas Policloradas/farmacocinética , Sistema Respiratório/química
5.
Environ Int ; 109: 81-88, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-28950160

RESUMO

Multiple chemicals are emitted in residential accommodation. Aggregate Daily Doses (ADD) (ng/kg-bw/d) were estimated for 32 semivolatile organic compounds (SVOCs) of different chemical families that are frequently detected in French dwellings in both air and settled dust. Daily doses were determined using steady-state models for the population, categorized into 11 age groups covering birth to age 30. Three routes of exposure were taken into account: dust ingestion, inhalation (gaseous and particulate phases) and dermal contact with the gaseous phase of air. Contamination levels were preferentially retrieved from large, nationwide representative datasets. A two-dimensional probabilistic approach was used to assess parametric uncertainty and identify the most influential factors. For children aged 2 to 3years, ADD estimates spanned orders of magnitude, with median values ranging from 8.7pg/kg-bw/d for 2,2',3,4,4'-pentabromodiphenylether (BDE 85) to 1.3µg/kg-bw/d for di-isobutyl phthalate (DiBP). Inhalation, ingestion and dermal pathway contributed at varying levels, and depending on compound, air was the dominant medium for 28 of the 32 compounds (either by inhalation or dermal contact). Indoor exposure estimate variance was mainly driven by indoor contamination variability, and secondarily by uncertainty in physical and chemical parameters. These findings lend support to the call for cumulative risk assessment of indoor SVOCs.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar em Ambientes Fechados/efeitos adversos , Compostos Orgânicos/análise , Adolescente , Adulto , Criança , Pré-Escolar , Dibutilftalato/análogos & derivados , Dibutilftalato/análise , Exposição Ambiental , Feminino , França , Habitação , Humanos , Lactente , Recém-Nascido , Masculino , Adulto Jovem
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