[The epidemiological and clinical characteristics of malaria under the present conditions of Tajikistan].

The highest malaria morbidity rates have been observed in the Tajikistan's Khatlon Region that is contiguous with Afghanistan. This area is notorious for its high malariogenicity ("susceptibility" according to the WHO terminology), caused by natural climatic factors, as well as a significant vulnerability associated with socioeconomic conditions (intensive migration of populations among which there are many infected subjects). In children, tropical malaria is generally characterized by an acute onset, abnormal fever, and its polymorphism of clinical manifestations that are exemplified by the lack of typical malaria paroxysms, as well as a gradual progression of parasitemia during the first malaria attacks. Recurrences are induced by ineffective treatment and chloroquine resistance in the tropical malaria pathogen. The reduction in malaria morbidity has resulted from a package of large-scale malaria-controlling measures implemented with the support of the Global Fund to Fight AIDS, Tuberculosis, and Malaria.

[The etiological structure of acute intestinal infections in children in the Republic of Tajikistan]. / Etiologicheskaia struktura ostrykh kishechnykh infektsii u detei v Respublike Tadzhikistan.

The Republic of Tajikistan belongs to the territories, traditionally hyperendemic with respect to acute enteric diseases (AED). The problem of AED still remains topical in recent years, especially among child population. The study of the etiological structure of AED in children has made it possible to establish that more than 70% of these diseases are of infectious nature. The leading role in the etiological structure of these diseases belongs to Shigella infections (32.4%), enterovirus diarrhea (12.1%) and Escherichia infections (8.9%). No significant differences in the character of the etiological structure of AED in children of urban and rural areas have been detected with the exception of enterovirus diarrhea, found to occur 2.7 times more frequently on children of urban areas (15.9%) than in those of rural areas (5.8%). The ascertaining of the etiological structure of AED in Tajikistan will make it possible to essentially increase epidemiological surveillance on AED and render it more concrete.

[Shigellosis and other acute intestinal infections in the Republic of Tajikistan: the epidemiological patterns]. / Shigellezy i drugie ostrye kishechnye infektsii v Respublike Tadzhikistan: épidemiologicheskie zakonomernosti.

Acute enteric infections (AEI), including shigellosis, are characterized by their extremely wide spread in Tajikistan. Their hyperendemicity is due to a high activity of the water route of transmission under the conditions of hot climate. The morbidity level of AEI both in the republic as a whole and in its individual territories has been found to directly depend on the degree of the potential epidemiological danger of the water supply system, as well as on the quality of water used by the population in the presence of its pronounced deficiency. The important role of breast feeding for the prophylaxis of AEI among young children is shown.

[The spread of rotavirus gastroenteritis in the Republic of Tajikistan]. / Rasprostranenie rotavirusnogo gastroénterita v Respublike Tadzhikistan.

The article deals with the results of the investigation which has demonstrated the spread of rotavirus infection on the territory of the Republic of Tajikistan. This infection has gained an important place in the regional pathology and requires increased epidemiological surveillance on its spread. As established in the course of this investigation, in patients with the clinical manifestations of pronounced gastroenteritis rotavirus plays the role of the etiological agent in 25.8% of cases in children aged up to 14 years and in 11.0% of cases in adults. Synchronism in the seasonal dynamics of morbidity in acute enteric infections of unclear etiology and rotavirus gastroenteritis among children aged 0-2 years, annually reaching morbidity peak in October, has been revealed. Rotavirus gastroenteritis requires close attention as regards its prophylaxis as one of the main nosological forms of acute enteric infections in the Republic.

[Viral hepatitis E: its epidemiological characteristics in the Republic of Tajikistan]. / Virusnyi gepatit E: épidemiologicheskie osobennosti v Respublike Tadzhikistan.

The characteristic feature of the Republic of Tajikistan, as well as other republics of Central Asia, is the wide spread of virus hepatitis E. The epidemiology of this grave disease, recently known as virus hepatitis non A, non B with the fecal-oral mechanism of transmission of this infection, has been yet insufficiently studied. The article points out to the specific character of this infection which essentially differs, both epidemiologically and clinically, from other enteric hepatitis (hepatitis A), also hyperendemic for the republic. The results of the study of the immunostructure of the population with respect to both hepatitis E and hepatitis A are presented.