RESUMO
A new sesquiterpene lactone was obtained from the chloroform extract of Pseudoelephantopus spicatus. Its structure was elucidated by extensive one dimentional (1D) and 2D NMR spectroscopy and mass spectrometry. It was found to exhibit moderate antifungal activity against C albicans and A. niger, and low activity against T. mentagrophytes, S. aureus, E. coli and P. aeruginosa. It was inactive against B. subtilis.
Assuntos
Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Fungos/efeitos dos fármacos , Plantas Medicinais/química , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia , Bactérias/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Folhas de Planta/químicaRESUMO
Two new diterpenes (1 and 2) were obtained from the leaves of Tinospora rumphii, along with the known compounds tinotufolin D and vitexilactone. The structures of compounds 1 and 2 were established on the basis of spectroscopic studies.
Assuntos
4-Butirolactona/análogos & derivados , Diterpenos/isolamento & purificação , Plantas Medicinais/química , 4-Butirolactona/química , 4-Butirolactona/isolamento & purificação , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Filipinas , Extratos Vegetais/análise , Espectrofotometria Infravermelho , Espectrofotometria UltravioletaRESUMO
The leaves of Ficus pumila afforded a new neohopane (1) by silica gel chromatography. The structure of 1 was elucidated by 1D and 2D NMR and IR spectroscopy and mass spectrometry. It showed antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans with an average antimicrobial index of 0.5, 0.3, 0.3 and 0.7, respectively, at a concentration of 30 microg.
Assuntos
Anti-Infecciosos/isolamento & purificação , Rosales/química , Triterpenos/isolamento & purificação , Antibacterianos , Anti-Infecciosos/farmacologia , Bacillus subtilis/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Cromatografia em Gel , Escherichia coli/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Testes de Sensibilidade Microbiana , Pseudomonas aeruginosa/efeitos dos fármacos , Espectrofotometria InfravermelhoRESUMO
Lantana camara afforded a novel triterpene 22 beta-acetoxylantic acid and the known triterpenes, lantic acid, 22 beta-dimethylacryloyloxylantonolic acid, a mixture of 22 beta-dimethylacryloyloxy lantanolic acid and 22 beta-angeloyloxylantanolic acid and lantanolic acid. 22 beta-Acetoxylantic acid showed antimicrobial activity against Staphylococcus aureus and Salmonella typhi. This compound and 22 beta-dimethylacryloyloxy lantanolic acid also showed antimutagenic activity.
