[Use of triptorelin in the medical treatment of uterine myoma]. / L'impiego della triptorelina nella terapia medica dei miomi uterini.

Following the introduction of GnRH analogue drugs the medical treatment of uterine myomatosis has been proposed. The use of these compounds in fact causes a reduction in mean plasma levels of 17-beta-estradiol which is reflected in the target tissue of myomas. Using this hormone-dependence as a starting Tryptoreline point, the study examined the volumetric changes induced by LH-RH agonist analogue, Tryptoreline, administered to a group of 15 selected patients. The results are encouraging: in all cases there was a marked reduction of tumour volume ranging between 30 and 40%. The therapeutic effect, however, gradually wore off following the suspension of treatment. For this reason, the use of this analogue should be reserved for premenopausal or younger patients for the treatment of menometrorrhagic episodes, or as a preoperative therapy in order to limit blood loss during surgery.

[Psychosomatic effects of oral contraception]. / Effetti psicosomatici della contraccezione orale.

PIP: The authors gathered information from 242 respondents by means of a questionnaire on the body, psychophysical, and psychosexual changes resulting from oral contraceptive (OC) use. Group 1 (n=12) were examined at the Obstetric/Gynecology Clinic at Naples University and group 2 (n=140) at the Ordinary Ambulartory Clinic at the same institution. The motivations for contraceptive refusal were also examined. Analysis of the results noted a clear prevalence of psychosomatic effects in the 1st group as compared to the 2nd which evidenced a greater number of deep social-cultural problems. (author's modified)^ieng