Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Chem Biol Drug Des ; 95(1): 5-15, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31512386

RESUMO

sarco-endoplasmic reticulum Ca-ATPase (SERCA) is the major transporter present in sarco-endoplasmic reticulum (SR/ER), transporting calcium back into SR/ER from cytosol. The calcium-sequestering activity of SERCA facilitates relaxation in both cardiac and skeletal tissue. ER stress is one of the etiological factors in various diseases such as neurodegenerative diseases and diabetes. Disrupted calcium handling can cause ER stress. In the cardiac tissue, impairment of systolic and diastolic function can cause various cardiovascular diseases. SERCA ensures the proper calcium handling in cells and may act as a therapeutic target for the disease associated with dysregulation of calcium ions. This review examines the principle of calcium ion handling through SERCA and its role in various diseases.


Assuntos
Cálcio/metabolismo , Doenças Cardiovasculares/etiologia , Diabetes Mellitus/etiologia , Retículo Endoplasmático/metabolismo , Doenças Neurodegenerativas/etnologia , ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático/metabolismo , Animais , Transporte Biológico , Ativação Enzimática , Humanos , Processamento de Proteína Pós-Traducional
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...