Positive correlation between body weight and body mass index with blood pressure in young adults.

Study assessing the correlation between body weight and body mass index (BMI) with blood pressure in young adults is still limited. The aim of this was to investigate the link between body weight and BMI with blood pressure, as well as to assess how much increasing of body weight and BMI contribute to raising blood pressure in young men and women. A cross-sectional study was conducted among 1,107 healthy young adults aged 18-22 years (women, n=705; men, n=402). Chi-squared test was used to assess the association between body weight and BMI with blood pressure. The Pearson correlation and linear regression analysis were used to determine the correlation and direction of the relationship between body weight and BMI with blood pressure. Our data indicated the associations between body weight and BMI with blood pressure (both had p=0.001). There was a strong correlation between body weight and systolic blood pressure (SBP) (r=0.709; p<0.001), whereas the correlation between body weight and diastolic blood pressure (DBP) was moderate (r=0.374; p<0.001). BMI moderately influenced SBP and DBP (r=0.488 and r=0.358; p<0.001). A linear correlation analysis revealed a positive correlation between body weight and BMI with blood pressure, where an increase in body weight of 1 kg resulted an increase in SBP of 0.725 mmHg and DBP of 0.318 mmHg. In addition, an increase in BMI of 1 kg/m2 followed by an increase in SBP and DBP of 1.6 mmHg and 0.834 mmHg, respectively. This study highlights that nutritional status in young men and women is linked and has a positive correlation with blood pressure.

The Effect of Platelet-Rich Plasma on Type I Collagen Production, VEGF Expression, and Neovascularization after Femoral Bone Implants: A Study on Rat Models.

Introduction: Platelet-rich plasma (PRP) contains many growth factors, such as FGF, which induces the production of type I collagen, and VEGF, which induces neovascularization, all of which are important in bone healing. This study aimed to evaluate the effect of PRP administration on type I collagen production, VEGF expression, and neovascularization in rat models following femoral bone implants using K-wire. Methods: An experimental randomized control study was conducted on 24 white male rats (Rattus norvegicus) in the Wistar strain that underwent K-wire implantation, where PRP was administered to the treatment groups. The amount of type I collagen was measured by immunohistochemistry VEGF expression using sandwich ELISA, and neovascularization by histopathological examination. Results: The amount of type I collagen in the treatment group (50->150/field of view) was significantly higher than the control group (0-99/field of view; p=0.003). VEGF expression in the treatment groups was significantly higher than controls: 10.90±4.47 and 2.29±0.92, respectively (p=0.006). Mean number of new vessels formed on fibrotic capsules in the treatment groups was significantly (p=0.007) higher than the control groups (2.69±1.03 vs 0.67±0.52). Conclusion: The use of PRP significantly increased type I collagen production, VEGF expression, and neovascularization in rat models, elucidating the potential of PRP to be used in clinical settings to enhance the bone-healing process.

How is COVID-19 perceived by medical students? A survey in Aceh province, Indonesia.

The coronavirus disease 2019 (COVID-19) has burdened the health system and medical education programmes both locally and globally, requiring medical students to continue their education whilst engaging in prevention programmes to support primary health services. This study aims to describe medical students' knowledge, attitudes in the prevention of COVID-19, and to determine the relationship between the knowledge of COVID-19 preventive behaviour and attitudes towards it. This study used an analytical cross-sectional observational design with a sample of 290 students. Data were collected through a self-assessment method using a validated questionnaire. Analysis of the frequency distribution test for knowledge found that 54.1% of the respondents and 99.0% of the students had a good understanding of the mode of transmission of COVID-19. The majority of medical students (73.1%) also had a good attitude towards COVID-19 and around 84.3% of the students considered that good ethics is needed when coughing or sneezing during this pandemic. As many as 46.6% of the respondents had good preventive behaviour against COVID-19 and always imposed restrictions on using public transportation during a pandemic. The Spearman's correlation test shows a weak but meaningful relationship between knowledge (r = 0.214, p = 0.000) and COVID-19 preventive behaviour, and a significant relationship between attitudes (r = 0.477, p = 0.000) towards COVID-19 preventive behaviour. This study concludes that medical students have good knowledge, preventive behaviour and an understanding of infection risk. An enhanced knowledge and awareness will increase preventive behaviours that will provide support in controlling the disease.