[Various indicators of amphotericin B pharmacokinetics in infants with Candida meningitis during the 1st year of life]. / Nekotorye pokazateli farmakokinetiki amfoteritsina B u detei pervogo goda zhizni s meningitami kandidoznoi etiologii.

The incidence of candidiasis meningitis in infants has lately increased. This required choosing of the dose and regimen for the use of amphotericin B, the only drug effective in the treatment of generalized mycoses. The antibiotic levels in the blood and CSF were determined in 14 infants at various periods after discontinuation of intravenous drip infusion of amphotericin B. It was shown that the therapeutic concentrations of the antibiotic in the blood were attained when it was administered in a dose of 120-200 units/kg twice a day. For attaining the therapeutic concentrations of the antibiotic in the CSF, daily endolumbar administration of amphotericin B in a dose more than 10 units in addition to its intravenous drip infusions was required. Therefore, the tactics of amphotericin B use in the treatment of candidiasis meningitis in infants was developed.