Prognostic Value of Immunoscore in Colorectal Carcinomas.

Aims. Immunoscore, based on the evaluation of CD3+ and CD8+ densities in the center of the tumor and its invasive margin, is currently considered as a potential prognostic factor, particularly in colorectal carcinomas. In the current study, we aimed to assess the prognostic value of immunoscore in colorectal cancer stage I to IV, through a survival study. Methods and Results. It was a descriptive and retrospective study involving 104 cases of colorectal cancer. Data were collected over 3 years (2014-2016). An immunohistochemical study (anti-CD3, anti-CD8) by the tissue microarray technique was carried out in the areas of "hot spot" in the tumor center and invasive margin. A percentage was assigned to each marker and within each region. Then, the density was classified as "low" or "high," according to a cutoff fixed at the median of percentages. immunoscore was calculated by the method described by Galon et al. The prognostic value of the immunoscore was assessed through a survival study. The mean age of patients was 61.6 years. immunoscore was low in 60.6% (n = 63). Our study had shown that low immunoscore significantly deteriorates survival and a high immunoscore enhances survival significantly (P < .001). We found a correlation between immunoscore and T stage (P = .026). A multivariate showed that the predictive factors for survival were immunoscore (P = .001) and age (P = .035). Conclusions. Our study highlights the potential role of immunoscore as a prognostic factor in colorectal cancer. Its reproducibility and reliability allow its introduction into daily practice for better therapeutic management.

Confocal endomicroscopy for the diagnosis of pancreatic lesions.

Confocal endomicroscopy (EMC) is a thriving technology that allows real-time and non-invasive imaging in vivo. EMC demonstrated its effectiveness to differentiate neoplastic from normal tissue and to search dysplasia. In addition to the significant developments of this technique in Barrett oesophagus, celiac disease, characterization of colonic polyps, or monitoring of chronic inflammatory bowel disease, EMC is currently developing in bilio-pancreatic pathology. Indeed, it is currently used to characterize biliary stenosis as well as pancreatic lesions (especially cystic). The aim of our study was to evaluate through a review of the literature the value of this technique in the characterization of pancreatic lesions.