[PAF-acether antagonistic pyrrolo[1,2-c]thiazoles: from RP 48740 to RP 59227]. / Pyrrolo[1,2-c]thiazoles antagonistes du PAF-acéther: du RP 48740 au RP 59227.

The optimisation of the PAF antagonistic activity of RP 48740 led to the discovery of still more potent molecules of the pyrrolo[1,2-c]thiazole family: RP 52629, RP 52770 and RP 59227. The latter compound, for which a stereo-specific synthesis was developed, exhibits a very high potency as a PAF receptor antagonist.