RESUMO
Aim: Single-tooth implant restorations, whether screw-retained or cement-retained, are essential for prosthodontic rehabilitation despite having low design flexibility, cosmetic appeal, and high 5-year survival rates. Materials and Methods: A study involving 14 patients with missing mandibular first molars used 28 implants and cement-retained and screw-retained prostheses. Patients had a single edentulous gap, adequate dental hygiene, and sufficient bone volume at the implant site. The study adhered to the Helsinki Declaration, followed WHO 2007 safety guidelines, and evaluated soft tissue, bone height, and bone loss. Data analysis included the Student's t-test and Mann-Whitney U-test. Results: In patients between the ages of 17 and 46, single-implant restorations were compared with cement- and screw-retained at 6 months. Abutment screw loosening and peri-implant soft-tissue traits did not differ significantly from one another. Conclusion: The study compared screw- and cement-retained implant restorations in 28 single-tooth implant-supported prostheses over a 6-month functional loading period, finding no significant improvement in either approach.
RESUMO
Aim: The study's objective was to assess the dimensional accuracy of hybrid polyether and polyvinyl siloxane materials for implant impressions. Materials and Methods: Nine groups were created from 45 samples of various building materials and construction techniques from the study. Five samples were tested, and 45 impressions were recorded. Results: The hybrid non-splinted technique has improved implant site replication, accuracy, and low interimplant distance alterations. Conclusion: The finest possible reproduction of implant sites on the master cast was made feasible by the use of an open, non-splinted method and a hybrid polyvinyl siloxane-polyether impression material.
RESUMO
The incidence of primary liver tumors, hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and combined HCC/ICC (cHCC/CC) is increasing. For ICC, targeted therapy exists only for a small subpopulation of patients, while for HCC, Sorafenib and Lenvatinib are in use. Diagnosis of cHCC/CC is a great challenge and its incidence is underestimated, bearing the risk of unintended non-treatment of ICC. Here, we investigated effects of targeted inhibitors on human ICC cell lines (HUH28, RBE, SSP25), in comparison to extrahepatic (E)CC lines (EGI1, CCC5, TFK1), and HCC/hepatoblastoma cell lines (HEP3B, HUH7, HEPG2). Cells were challenged with: AKT inhibitor MK-2206; multikinase inhibitors Sorafenib, Lenvatinib and Dasatinib; PI3-kinase inhibitors BKM-120, Wortmannin, LY294002, and CAL-101; and mTOR inhibitor Rapamycin. Dosage of the substances was based on the large number of published data of recent years. Proliferation was analyzed daily for four days. All cell lines were highly responsive to MK-2206. Thereby, MK-2206 reduced expression of phospho(p)-AKT in all ICC, ECC, and HCC lines, which mostly corresponded to reduction of p-mTOR, whereas p-ERK1/2 was upregulated in many cases. Lenvatinib showed inhibitory effects on the two HCC cell lines, but not on HEPG2, ICCs and ECCs. Sorafenib inhibited proliferation of all cells, except the ECC line CCC5. However, at reduced dosage, we observed increased cell numbers in some ICC experiments. Dasatinib was highly effective especially in ICC cell lines. Inhibitory effects were observed with all four PI3-kinase inhibitors. However, cell type-specific differences were also evident here. Rapamycin was most effective in the two HCC cell lines. Our studies show that the nine inhibitors differentially target ICC, ECC, and HCC/hepatoblastoma lines. Caution should be taken with Lenvatinib and Sorafenib administration in patients with cHCC/CC as the drugs may have no effects on, or might even stimulate, ICC.
