1.
Farmakol Toksikol
; 49(2): 45-8, 1986.
Artigo
em Russo
| MEDLINE
| ID: mdl-2940112
RESUMO
Polymer proanthocyanidin from Rhodiola semenovii named epihalochin was found to exhibit a pronounced antihypoxic effect in different models of hypoxia (hypoxic, cytotoxic and hemic), to relieve the hypoxic isolated heart contracture. Therapeutic doses of epihalochin produced a transient lowering of arterial pressure, decreased to a certain degree heart rate and lengthened the phases of cardiac contractions.
Assuntos
Antocianinas/farmacologia , Biopolímeros , Plantas Medicinais , Polímeros/farmacologia , Animais , Antocianinas/uso terapêutico , Antocianinas/toxicidade , Relação Dose-Resposta a Droga , Avaliação Pré-Clínica de Medicamentos , Feminino , Cobaias , Hemodinâmica/efeitos dos fármacos , Hipóxia/tratamento farmacológico , Técnicas In Vitro , Dose Letal Mediana , Masculino , Camundongos , Contração Miocárdica/efeitos dos fármacos , Polímeros/uso terapêutico , Polímeros/toxicidade , Ratos , Estresse Psicológico/tratamento farmacológico , Uzbequistão
2.
Farmakol Toksikol
; 47(3): 55-8, 1984.
Artigo
em Russo
| MEDLINE
| ID: mdl-6428935
RESUMO
It has been demonstrated in acute experiments on animals of different species that nitroesters of sodium carboxymethylcellulose have the pharmacological properties exhibited by nitroglycerin. Unlike the latter one, they exert a mild hypotensive action.