Sustainable utilization of incineration bottom ash in pavement construction: Environmental impacts and life cycle assessment.

The global drive towards sustainable development has prompted a notable shift in civil engineering practices towards utilizing secondary materials, such as incineration bottom ash (IBA). The literature review underscores the relevance of waste incineration and the crucial need for effective IBA management strategies. Existing studies, however, reveal a dearth of studies within the life cycle assessment (LCA) framework focusing on understanding IBA characteristics and field conditions. The study addresses this gap by proposing an LCA to assess the environmental implications of substituting natural aggregates with IBA in pavement layers. A comparative LCA was carried out, where different scenarios of reuse of IBA (as produced, treated, or with restrictions) were assessed against a baseline scenario that represents the conventional use of aggregates in roads and landfilling of IBA. The ReCiPe technique, incorporating a hierarchist perspective, was employed to assess impacts across different problem-oriented categories. Additionally, this study also explores the impact of data variability on LCA outcomes, considering changes in landfill height, pavement infiltration rate, time duration, and IBA transportation distance. The analysis indicates that incorporating IBA in road layers can significantly reduce impacts on non-toxic categories like global warming by over 35 %. However, the leaching properties of untreated IBA contribute to a more than 28 % increase in human carcinogenic toxicity, rendering it environmentally unsuitable for road layer reuse. The comparative study illustrated that reusing treated IBA is the most sustainable approach, remaining effective up to a distance of d + 15 km. In cases where treatment is not feasible, utilizing IBA with restrictions is recommended up to a distance of d + 5 km (d represents the transportation distance for natural materials). This research fills a critical gap in the literature by providing a framework to assess IBA reuse in road construction, thereby advancing the discourse on sustainable materials management in the construction industry.

Optimizing MSW incineration bottom ash reuse: A study on treated wastewater washing and leaching control.

The current study introduces an innovative methodology by utilizing treated wastewater (TWW) from an effluent treatment plant as a washing agent to enhance the characteristics of incineration bottom ash (IBA). This approach addresses sustainability concerns and promotes the circular economy by reusing wastewater generated in municipal solid waste incineration facilities. Previous research has underscored the challenges of open IBA reuse due to elevated leaching of chlorides, sulfates, and trace metal(loid)s. Thus, the experimental setup explores various combinations of washing, with or without screening, to optimize the properties of soil-like material (SLM < 4.75 mm) and overall material (OM < 31.5 mm) fractions of IBA for unrestricted applications. Batch leaching tests were conducted on treated samples, and leaching characteristics were evaluated in accordance with regulatory standards, primarily the Dutch standard for unrestricted IBA reuse. The findings reveal that washing in isolation proves insufficient to enhance IBA properties; however, washing followed by screening, specifically for removing fines (<0.15 mm), proves effective in reducing contamination. The study identifies that multiple steps of washing and screening (with recirculation) process render OM and SLM fractions suitable for unrestricted reuse with a cumulative liquid-to-solid ratio of 6 L/kg and a total washing time of 15 min. The multi-step treatment was found effective in reducing sulfate contamination by 65-74 % and chloride contamination by 83-89 % in IBA fractions. This approach offers a promising solution for overcoming the limitations associated with IBA leaching, thereby promoting sustainable waste reuse practices.

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae.

Carbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 µg/L) and assessing the phenotypic and transcriptomic profile at different developmental stages [24 hour post fertilization (hpf), 48 hpf, 72 hpf and 96 hpf). At 48 hpf, phenotypic abnormalities such as delay in hatching rate, deformed spinal axial curvature, and pericardial edema were observed in zebrafish larvae over its respective controls. At 72 hpf, exposure of zebrafish embryos exposed to carbendazim resulted in scoliosis; however, unexposed larvae did not exhibit signs of scoliosis. Interestingly, the transcriptomic analysis revealed a total of 1253 DEGs were observed at selected time points, while unique genes at 24 hpf, 48 hpf, 72 hpf and 96 hpf was found to be 76.54 %, 61.14 %, 92.98 %, and 68.28 %, respectively. Functional profiling of downregulated genes revealed altered transcriptomic markers associated with phototransduction (24 hpf and 72 hpf), immune system (48 hpf), and SNARE interactions in the vesicular pathway (96 hpf). Whereas functional profiling of upregulated genes revealed altered transcriptomic markers associated with riboflavin metabolism (24 hpf), basal transcription factors (48 hpf), insulin signaling pathway (72 hpf), and primary bile acid biosynthesis (96 hpf). Taken together, carbendazim-induced developmental toxicity could be ascribed to pleiotropic responses at the molecular level, which in turn might reflect phenotypic abnormalities.

Investigation on trommeled legacy waste from full-scale mining of old dumpsites: Suitable for valorization or scientific disposal?

The burgeoning interest in resource recovery from old dumpsites has significantly propelled the adoption of Landfill Mining (LFM) in recent years. This study is centred around evaluating the quality of materials recovered from the full-scale LFM activities at two major dumpsites in India, focusing on the valorization potential of the segregated legacy waste. A detailed analysis was conducted on the segregated waste fractions based on particle size (-30 mm, 30 to 6 mm, and -6 mm, as sourced from the sites), employing both batch and column leaching methods across a range of liquid-to-solid (L/S) ratios (0.1-10.0 L/kg). The findings reveal a pronounced concentration of contaminants within the -6 mm fraction compared to the 30 to 6 mm and -30 mm fractions. Column leaching tests revealed a reduction in contaminant concentration, correlating with incremental changes in L/S ratio. Notably, this trend remained consistent across varying particle sizes and specific type of contaminants assessed. Notably, color intensity of leachate reduced significantly from 720 to 1640 Platinum Cobalt Units (PCU) at an L/S ratio of 0.1 L/kg to a minimal 94-225 PCU at an L/S of 10 L/kg. Dissolved salts emerged as a primary concern, marking them as significant contaminants in both leaching methods. The analysis confirmed that the segregated fractions comply with the USEPA Waste Acceptance Criteria (WAC), permitting their disposal in non-hazardous waste landfills. However, the elevated presence of dissolved salts, exceeding reuse limits by 5-35 times, limits their open or unrestricted reuse. Despite this, isolated reuse aligns with regulations from the Netherlands and Germany, suggesting viable pathways for compliant utilization. Geotechnical assessments indicate the potential for repurposing the -30 mm fraction as alternative earthfill and construction material. While heavy metal leaching does not pose significant concerns, the prevalent unscientific disposal practices near urban settlements highlight potential human health risks. This investigation enriches the understanding of the physicochemical properties, leaching behaviour, and reuse potential of segregated legacy waste, offering crucial insights for civic authorities in determining appropriate reuse and disposal strategies for such materials.

Optimisation and interpretation of machine and deep learning models for improved water quality management in Lake Loktak.

Loktak Lake, one of the largest freshwater lakes in Manipur, India, is critical for the eco-hydrology and economy of the region, but faces deteriorating water quality due to urbanisation, anthropogenic activities, and domestic sewage. Addressing the urgent need for effective pollution management, this study aims to assess the lake's water quality status using the water quality index (WQI) and develop advanced machine learning (ML) tools for WQI assessment and ML model interpretation to improve pollution management decision making. The WQI was assessed using entropy-based weighting arithmetic and three ML models - Gradient Boosting Machine (GBM), Random Forest (RF) and Deep Neural Network (DNN) - were optimised using a grid search algorithm in the H2O Application Programming Interface (API). These models were validated by various metrics and interpreted globally and locally via Partial Dependency Plot (PDP), Accumulated Local Effect (ALE) and SHapley Additive exPlanations (SHAP). The results show a WQI range of 72.38-100, with 52.7% of samples categorised as very poor. The RF model outperformed GBM and DNN and showed the highest accuracy and generalisation ability, which is reflected in the superior R2 values (0.97 in training, 0.9 in test) and the lower root mean square error (RMSE). RF's minimal margin of error and reliable feature interpretation contrasted with DNN's larger margin of error and inconsistency, which affected its usefulness for decision making. Turbidity was found to be a critical predictive feature in all models, significantly influencing WQI, with other variables such as pH and temperature also playing an important role. SHAP dependency plots illustrated the direct relationship between key water quality parameters such as turbidity and WQI predictions. The novelty of this study lies in its comprehensive approach to the evaluation and interpretation of ML models for WQI estimation, which provides a nuanced understanding of water quality dynamics in Loktak Lake. By identifying the most effective ML models and key predictive functions, this study provides invaluable insights for water quality management and paves the way for targeted strategies to monitor and improve water quality in this vital freshwater ecosystem.

Identification and assessment of appropriate remediation management techniques for the recovery of soil-like material produced in landfill mining.

Landfill mining has received major attention in recent years for the reclamation of waste disposal sites, including in developing countries such as India where significant efforts are being made to manage sites in this way. The bulk of the material obtained from landfill mining consists of fine-grained soil-like material (SLM) but its direct reuse in off-site applications is restricted due to the presence of harmful heavy metals, soluble salts and other pollutants. In this study, appropriate techniques for managing SLM to permit recovery and reuse are assessed. As a result, experimental investigation explores the efficacy of two remediation techniques considered appropriate for SLM management: electrokinetic remediation and phytoremediation. These were applied to SLM from a recently mined landfill and their ability to reduce heavy metal and other soluble salt burdens assessed. Electrokinetic remediation has shown considerable potential to mobilise and transport heavy metals and soluble salts through and from the SLM over an eight-week period. Phytoremediation experiments also demonstrated mobilisation and uptake of metals from the SLM over a similar duration although relatively low amounts were recovered as a result of the low biomass produced over this period. Both technologies have demonstrated potential for recovery of metals from SLM, as well as recovering the SLM itself as a potential resource.

Characterization of MSW incineration bottom ash for use as structural fill in reinforced soil structures: Geoenvironmental, geotechnical and economical assessment.

The study presents the geoenvironmental and geotechnical characterization of MSW incineration bottom ash (IBA) and examines its reuse as structural fill in reinforced soil structures (RSS).The suitability of reuse has been assessed with regard to international regulatory standards. The prime focus of the work remains on evaluating the pullout response of geosynthetic reinforcements through IBA fill to determine the interaction coefficient, which has never been addressed in the literature. The economic viability of using IBA instead of locally available river sand for a 12 m high MSE wall is also established. The column leaching test results confirm that IBA can be utilized in RSS with suitable design measures. The geotechnical investigation shows that IBA is a well-graded, non-plastic lightweight material with adequate drainage and high shear strength. The pullout test results demonstrate that the interaction coefficient of polymeric strips and geogrid in IBA (0.73-1.53 and 0.79-1.91, respectively) is comparable or higher to materials conventionally used as structural fill in RSS, indicating adequate bondage between IBA and geosynthetic reinforcement. Further, it is estimated that using IBA as a substitute for available river sand in the vicinity can potentially reduce the overall RSS project cost by 15-20%, even if IBA has to be transported 50 km away from the project site.

An investigation on mobility of heavy metals for assessing the reusability of soil-like material reclaimed from mining of municipal solid waste dumpsites.

Landfill mining, often referred to as "bio-mining", enables the recovery of resources, including combustible, compostable, and recyclable fractions from landfills. However, most of the materials mined from old landfills mainly consist of soil-like materials (SLM). The reuse of SLM depends on the concentration of contaminants, such as heavy metals, soluble salts, etc. A sound risk assessment requires sequential extraction to determine the bioavailability of heavy metals. This study focuses on the mobility and chemical speciation of heavy metals in SLM from four old municipal solid waste dumpsites in India by performing selective sequential extraction. Additionally, the study compares the results with those of four previous investigations to identify international similarities. It has been observed that Zn was mainly available in the reducible phase (average 41%), whereas Ni and Cr proved to have the highest distribution in the residual phase (64% and 71%, respectively). Pb analysis showed a large portion in the oxidizable phase (39%), while Cu was mainly present in the oxidizable (37%) and residual (39%) phases. Similarities with previous investigations were observed for Zn (primarily reducible 48%), Ni (residual 52%), and Cu (oxidizable 56%). Correlation analysis showed that Ni correlated with all heavy metals (ρ = 0.71-0.78), except with Cu. The present study suggested that Zn and Pb are associated with a high risk of pollution due to their maximum distribution in the bioavailable phase. The findings of the study can be used to assess the heavy metal contamination potential of SLM prior to its reuse in offsite applications.

Utility of prehospital call center ambulance dispatch data for COVID-19 cluster surveillance: A retrospective analysis.

INTRODUCTION: Cluster surveillance, identification, and containment are primary outbreak management techniques; however, adapting these for low- and middle-income countries is an ongoing challenge. We aimed to evaluate the utility of prehospital call center ambulance dispatch (CCAD) data for surveillance by examining the correlation between influenza-like illness (ILI)-related dispatch calls and COVID-19 cases. METHODS: We performed a retrospective analysis of state-level CCAD and COVID-19 data recorded between January 1 and April 30, 2020, in Telangana, India. The primary outcome was a time series correlation between ILI calls in CCAD and COVID-19 case counts. Secondarily, we looked for a year-to-year correlation of ILI calls in the same period over 2018, 2019, and 2020. RESULTS: On average, ILI calls comprised 12.9% (95% CI 11.7%-14.1%) of total daily calls in 2020, compared to 7.8% (95% CI 7.6%-8.0%) in 2018, and 7.7% (95% CI 7.5%-7.7%) in 2019. ILI call counts from 2018, 2019, and 2020 aligned closely until March 19, when 2020 ILI calls increased, representing 16% of all calls by March 23 and 27.5% by April 7. In contrast to the significant correlation observed between 2020 and previous years' January-February calls (2020 and 2019-Durbin-Watson test statistic [DW] = 0.749, p < 0.001; 2020 and 2018-DW = 1.232, p < 0.001), no correlation was observed for March-April calls (2020 and 2019-DW = 2.012, p = 0.476; 2020 and 2018-DW = 1.820, p = 0.208). In March-April 2020, the daily reported COVID-19 cases by time series significantly correlated with the ILI calls (DW = 0.977, p < 0.001). The ILI calls on a specific day significantly correlated with the COVID-19 cases reported 6 days prior and up to 14 days after (cross-correlation > 0.251, the 95% upper confidence limit). CONCLUSIONS: The statistically significant time series correlation between ILI calls and COVID-19 cases suggests prehospital CCAD can be part of early warning systems aiding outbreak cluster surveillance, identification, and containment.

Qualitative comparison of elemental concentration in soils and other geomaterials using FP-XRF.

Field portable X-ray fluorescence (FP-XRF) has tremendous potential in geoenvironmental engineering as a qualitative assessment tool. Identification of the elevated concentrations of the selected elements (Cr, Cu, Mn, Ni, Pb, and Zn) in various geomaterials like soil-like-material (SLM), incinerated bottom ash (IBA), construction and demolition waste (CDW), zinc tailings (ZT) and fly ash (FA) was performed by FP-XRF and compared with the local soil-Delhi silt. Comparably higher concentrations (mg/kg) of Cr (401.0), Cu (499.0), Pb (532.0), Zn (608.0) in SLM, Cr (195.0), Cu (419.0), Ni (93.0), Pb (931.0), Zn (771.0) in IBA and Cr (195.0), Cu (4000.0), Pb (671.0), Zn (7122.0) in ZT were observed. CDW and FA showed similar concentrations range as in local soils. FP-XRF was also used in-situ on local soil at 11 sites to examine its ability to identify the elements with significant variations in concentrations. The results showed high variability in Cl and S concentration values across the 11 sites attributed to the changing moisture content and dissolved salts. The concentration range for the remaining elements were similar at all sites. The verification of the detected elements through visual inspection of the spectrum was also carried out.

Contaminants of concern (CoCs) pivotal in assessing the fate of MSW incineration bottom ash (MIBA): First results from India and analogy between several countries.

Present study characterizes municipal solid waste incineration bottom ash (MIBA) from three incineration plants in Delhi with an intent to serve the dual objectives: a) assessing the disposal/reuse options for Delhi MIBA, b) evaluating variability in results across the countries (including India) and assessing if is significant enough to influence the fate of MIBA of varied origin. A review on leaching studies of MIBA (50 research papers) was conducted which aided in achieving both the objectives. Delhi MIBA samples were analysed for chemical composition. The two commonly adopted leaching tests i.e., TCLP and EN 12457-2, were conducted and the results were checked against regulatory threshold levels (RTLs) to achieve the first objective. Leaching concentration of the contaminants was compared with the compiled literature and RTLs to accomplish the second objective. The compendium of literature most importantly revealed the physicochemical parameters which are pivotal in determining the fate of MIBA but have been missing from many studies. Ten such parameters were identified: Cr, Cu, Mo, Sb, Cl-,SO42-, Cd, Pb, Ni and Zn and are referred as contaminants of concern (CoCs). Delhi MIBA was found suitable for disposal to non-hazardous waste landfills and unsuitable for unrestricted reuse. CoCs identified in Delhi MIBA were identical to those observed in literature (except Cd, Pb and Zn). The variability in leaching concentration of CoCs, observed from comparative assessment of results, spanned nearly 2 to 3 log10 magnitudes for Cu, Cr, Pb, Sb and Zn while 1 to 2 log10 magnitudes for Mo, Cl-andSO42-.

Elevated Serum SIRT 2 May Differentiate Parkinson's Disease From Atypical Parkinsonian Syndromes.

Atypical Parkinson syndromes (APSs) often have symptoms that overlap with those of Parkinson's disease (PD), especially early in the disease, making these disorders difficult to diagnose. Previous studies have demonstrated an association of oligomeric α-synuclein (α-Syn), a key element in the pathogenesis of PD, with Sirtuin (SIRT)2 proteins for modulating PD. We aimed to evaluate SIRT protein expression in serum of PD patients and compare it with APSs and normal elderly control (GC) and to correlate this with α-Syn. SIRT protein expression was evaluated in sera of 68 PD; 34 APS and 68 GC without any neuro-psychiatric illness as controls by surface plasmon resonance (SPR). SIRT2 expression was correlated with α-Syn in PD and GC. Significant (p < 0.0001) differences were observed between serum SIRT2 concentration in PD and APS and GC as well as between APS and GC. Receiver operating characteristic (ROC) analysis revealed the strong cut-off value to differentiate PD from APS and GC and also APS from GC. Significant correlation was observed among SIRT2 levels in early PD patients with Unified Parkinson's Disease Rating Scale (UPDRS), Hoehn & Yahr (H & Y) and increased duration of disease. In addition, a strong positive correlation of SIRT2 with α-Syn (p < 0.0001) was observed. However, no such difference was detected for serum SIRT1 in cases of PD and APS or for GC. The present study is the first to report elevated serum SIRT2 in PD. The study also provided a simple test to distinguish PD from APS and may have translational utility for diagnosis.

Effects of poplar addition on tar formation during the co-pyrolysis of fat coal and poplar at high temperature.

Three-stage absorption by butyl acetate was used to obtain tar components during the co-pyrolysis of fat coal and poplar at high temperature. The resulting tar yields were calculated relative to the fat coal and poplar blends. The tar components were characterized by gas chromatography-mass spectrometry, Fourier transform-infrared spectroscopy and 1H nuclear magnetic resonance spectroscopy. The effects of the added poplar on tar formation were then considered. The results show that the poplar-fat coal tar yield rose slightly when the poplar addition levels ranged from 4% to 12% and then increased much more at higher poplar addition levels. Oxygenated and aromatic compounds contributed greatly to the poplar-fat coal tar yield. The quantity of oxygenated components increased in the poplar blending ratio range from 4% to 12% and decreased as the ratio increased further, while the quantity of aromatic components showed the opposite trend. The influences of poplar addition levels on tar formation could be divided into two stages: (a) lighten the tar by stabilizing radicals at low poplar addition levels; (b) form heavier tar due to cross-linking reactions of the remaining radicals at high poplar addition levels. When the poplar addition levels ranged from 4% to 12%, due to synergistic effects, large amounts of free radicals and hydrogen from the co-pyrolysis of coal and poplar formed lighter stable compounds, which were then transported into the tar. Further, cross-linking reactions could be decreased because fewer free radicals and less hydrogen remained. As a result, the amount of PAHs declined, the tar yield rose slightly, the hydrocarbon-generating potential improved, the aliphatic chain length shortened, and the aromatic protons decreased. At higher blending ratios, excess radicals existed after stabilization due to the increasing poplar addition levels. These radicals underwent cross-linking reactions and produced PAHs, resulting in heavily increased tar yields, weakened hydrocarbon-generating potential, extended aliphatic chain lengths and increased aromatic protons.

Investigations on fine fraction of aged municipal solid waste recovered through landfill mining: Case study of three dumpsites from India.

Reclamation of the dumps/landfills having huge quantities of decades-old garbage (aged waste or legacy waste) in an environmentally sound manner is one of the major challenges faced by the developing nations in general and in particular by urban local bodies in India. The article presents the feasibility of landfill mining operation specifically to recover soil-like material at old dumpsites of India for re-use in geotechnical applications. Aged municipal solid waste was collected from three dumpsites of India and initial tests were conducted on the soil-like material of the municipal solid waste. Initial tests results of grain size distribution, compositional analysis, organic content, total dissolved solids, elemental analysis, heavy metal analysis and colour of the leached water from finer fraction of aged municipal solid waste are presented. From the preliminary investigation, it was found that organic content in 15-20-year-old dumpsites varies between 5%-12%. The total dissolved solids ranges between 1.2%-1.5%. The dark coloured water leaching out from aged waste, with reference to local soil, is one of the objectionable parameters and depends on the organic content. The concentration of heavy metals of the finer fraction were compared with the standards. It was found that copper, chromium and cadmium are present at elevated levels in all the three dumpsites. The study concluded that the bulk of the soil-like material from aged municipal solid waste landfills can be used as cover material for landfills at the same site. However, some treatment in terms of washing, thermal treatment, blending with local soil, biological treatment, etc., is required before it can be re-used in other geotechnical applications.

p-Hexafluoroisopropanol phenyl functionalized graphene for QCM based detection of dimethyl methylphosphonate, a simulant of the nerve agent sarin.

The detection of DMMP (dimethyl methylphosphonate, a simulant of nerve agent sarin) was performed by using p-hexafluoroisopropanol phenyl (HFIPP) functionalized graphene (GR) via hydrogen bond interactions. For this, the HFIPP moiety was covalently functionalized on the surface of GR by a diazo reaction. The HFIPP-GR film-modified QCM electrodes were fabricated and their sensing characteristics towards DMMP were investigated. The proposed sensor showed good response towards sensing DMMP vapor at room temperature. In order to see the effect of HFIPP derivatives on DMMP vapor sensing, a comparative study was also conducted with unfunctionalized graphene. The sensitivity and detection limit of the HFIPP-GR sensor against DMMP vapors were 12.24 Hz ppm-1 and 150 ppb respectively. The HFIPP-GR coated sensors showed good selectivity towards sensing DMMP vapors when compared with common organic vapors.

Mechanical characterization of municipal solid waste from two waste dumps at Delhi, India.

The article presents the physical and mechanical properties of the emplaced municipal solid waste (MSW) recovered from different locations of the Ghazipur and Okhla dumps both located at Delhi, India. Mechanical compressibility and shear strength of the collected MSW were evaluated using a 300×300mm direct shear (DS) shear box. Compression ratio (Cc') of MSW at these two dumps varied between 0.11 and 0.17 and is falling on the lower bound of the range (0.1-0.5) of the data reported in the literature for MSW. Low Cc' of MSW is attributed to the relatively low percentages of compressible elements such as textiles, plastics and paper, coupled with relatively high percentages of inert materials such as soil-like and gravel sized fractions. Shear strength of MSW tested is observed to be displacement dependent. The mobilized shear strength parameters i.e., the apparent cohesion intercept (c') and friction angle (ϕ') of MSW at these two dumps are best characterized by c'=13kPa and ϕ'=23° at 25mm displacement and c'=17kPa and ϕ'=34° at 55mm displacement and are in the range reported for MSW in the literature. A large database on the shear strength of MSW from 18 countries that includes: the experimental data from 277 large-scale DS tests (in-situ and laboratory) and the data from back analysis of 11 failed landfill slopes is statistically analyzed. Based on the analysis, a simple linear shear strength envelope, characterized by c'=17kPa and ϕ'=32°, is proposed for MSW for preliminary use in the absence of site-specific data for stability evaluation of the solid waste landfill under drained conditions.

Study of stress-strain and volume change behavior of emplaced municipal solid waste using large-scale triaxial testing.

The article presents the stress-strain and volume change behavior, shear strength and stiffness parameters of landfilled municipal solid waste (MSW) collected from two dump sites located in Delhi, India. Over 30 drained triaxial compression (TXC) tests were conducted on reconstituted large-scale specimens of 150mm diameter to study the influence of fiber content, age, density and confining pressure on the shear strength of MSW. In addition, a few TXC tests were also conducted on 70mm diameter specimen to examine the effect of specimen size on the mobilized shear strength. It is observed that the fibrous materials such as textiles and plastics, and their percentage by weight have a significant effect on the stress-strain-volume change behavior, shear strength and stiffness of solid waste. The stress-strain-volume change behavior of MSW at Delhi is qualitatively in agreement with the behavior reported for MSW from different countries. Results of large-scale direct shear tests conducted on MSW with an identical composition used for TXC tests revealed the cross-anisotropic behavior as reported by previous researchers. Effective shear strength parameters of solid waste evaluated from this study is best characterized by ϕ'=39° and c'=0kPa for the limiting strain-based failure criteria of K0=0.3+5% axial strain and are in the range of the data reported for MSW from different countries. Data presented in this article is useful for the stress-deformation and stability analysis of the dump sites during their operation as well as closure plans.

Efficacy of Standardized Extract of Bacopa monnieri (Bacognize®) on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.

Rationale. Bacopa monnieri, popularly known as Brahmi, has been traditionally used in Ayurveda since ages for its memory enhancing properties. However, data on placebo-controlled trial of Bacopa monnieri on intellectual sample is scarce. Hence this study was planned to evaluate the effect of Bacopa monnieri on memory of medical students for six weeks. Objective. To evaluate the efficacy of Bacopa monnieri on memory of medical students with six weeks' administration. Method and Material. This was a randomized double blind placebo-controlled noncrossover, parallel trial. Sixty medical students of either gender from second year of medical school, third term, regular batch, were enrolled from Government Medical College, Nagpur, India. Baseline biochemical and memory tests were done. The participants were randomly divided in two groups to receive either 150 mg of standardized extract of Bacopa monnieri (Bacognize) or matching placebo twice daily for six weeks. All baseline investigations were repeated at the end of the trial. Students were followed up for 15 days after the intervention. Results. Statistically significant improvement was seen in the tests relating to the cognitive functions with use of Bacopa monnieri. Blood biochemistry also showed a significant increase in serum calcium levels (still within normal range).

Electrochemically Active Polyaniline (PANi) Coated Carbon Nanopipes and PANi Nanofibers Containing Composite.

A composite constituted by carbon nanopipes (CNPs) and polyaniline nanofibers (PANi NFs) is synthesized using in-situ chemical oxidative polymerization. Owing to its electrochemical activity the composite is found to be suitable as a working electrode material in hybrid type supercapacitors. Microstructural and phase analyses of the composite showed that (i) CNP surfaces are coated with PANi and (ii) PANi coated CNPs are distributed among PANi NFs. The composite shows an excellent electrochemical activity and a high specific capacitance of ~224.39 F/g. The electro-chemical activity of the composite is explicated in correlation with crystallinity, intrinsic oxidation state, and doping degree of PANi in the composite. The electro-chemical activity of the composite is also explicated in correlation with BET surface area and ordered meso-porosity pertaining to the composite. Charge/discharge curves indicate that the specific capacitance of the composite is a result of electric double-layer capacitance offered by CNPs and Faradaic pseudo capacitance offered by PANi NFs.

Treatment of uncomplicated symptomatic urinary tract infections: Resistance patterns and misuse of antibiotics.

INTRODUCTION: Uncomplicated but symptomatic urinary tract infections (UTIs) are a common problem seen in practice. The study was undertaken to assess the most common pathogens responsible for uncomplicated symptomatic UTIs and the antimicrobial resistance pattern in a hospital in Bangalore. The study also explores the issue of antibiotic usage for these patients. MATERIALS AND METHODS: The study was conducted in the Medicine department of a tertiary hospital in Bangalore. In all, 196 patients presented with symptoms of UTI. Bacterial growth was determined by standard microbiology techniques on freshly voided mid-steam urine samples collected from recruited patients. Patients' demographic data, urine culture results, resistance rates to antimicrobial agents and prescribed empiric antimicrobial therapy were analyzed. RESULTS: The prevalence of UTI was 32.1%; majority (67.9%) of the symptomatic did not have UTI based on culture report. Gram-negative bacteria constituted the largest group with a prevalence of 84.1% (53/63), with Escherichia coli being the most common (70%) uropathogen. Gram-negative isolates showed high level of sensitivity to amikacin (90.6%) and nitrofurantoin (77.4%). Most of the gram-positive organisms were susceptible to nitrofurantoin (70%) and gentamicin (50%). Uropathogens isolated demonstrated high resistance to cotrimoxazole, fluoroquinolones, and beta-lactam antibiotics. It was found out that 30.1% of the patients were wrongly managed of which 14.7% were over treated. CONCLUSION: UTI can be over diagnosed and over treated on the basis of clinical signs, symptoms and urine microscopy. In the era of emerging anti-microbial resistance, effective counseling and delay in antibiotic initiation or empirical therapy with a short course of nitrofurantoin is highly recommended. Empirical therapy guidelines should be updated periodically to reflect changes in antimicrobial resistance of uropathogens.