Comparison of prognosis between hyperbilirubinemic infants with and without hypernatremia.

OBJECTIVES: Hypernatremia may facilitate the diffusion of bilirubin through the blood-brain barrier and increase the risk of bilirubin encephalopathy. This study was conducted to compare the prognosis of jaundice infants with those with jaundice and hypernatremia. METHODS: A total of 615 term infants with idiopathic jaundice with or without hypernatremia were enrolled in this cohort study with 24-months follow-up at Ghaem Hospital, Mashhad, Iran, between 2010 and 2022. An in-house questionnaire including the laboratory evaluation and neonatal characteristics was used as the data collection tool. The follow-up of neonatal development status was performed using the Denver test II at 6, 12, 18, and 24 months after discharging from hospital. RESULTS: Normal outcomes were seen in 555 (90.2%) out of 615 studied infants, while 60 cases (9.8%) showed abnormal outcomes. Serum levels of sodium (P = 0.017), bilirubin (P = 0.001), urea (P = 0.024), and creatinine (P = 0.011) as well as hyperthermia (P = 0.046) and unconsciousness (P = 0.005) showed significant differences between the two groups. Approximately 16% of the newborns with both jaundice and hypernatremia, and 9% of those with only jaundice had unfavorable prognoses. Also, bilirubin level had the most predictive power (91.3%). CONCLUSIONS: Our results suggest that hypernatremia or jaundice alone, may affect the prognosis of infants aged 2 years; but jaundice and hypernatremia together, will intensify the developmental problems in jaundice infants. However, the role of hyperbilirubinemia in the incidence of complications is more than hypernatremia.

Magnetization reversal properties and magnetostatic interactions of disk to rod-shaped FeNi layers separated by ultra-thin Cu layers.

From fast magnetic memories with low-power consumption to recording media with high densities, realizing the magnetization reversal and interaction of magnetic layers would allow for manipulating the ultimate properties. Here, we use a pulsed electrochemical deposition technique in porous alumina templates (50 nm in pore diameter) to fabricate arrays of nanowires, consisting of FeNi layers (26-227 nm in thickness) with disk to rod-shaped morphologies separated by ultra-thin (3 nm) Cu layers. By acquiring hysteresis curves and first-order reversal curves (FORCs) of the multilayer nanowire arrays, we comprehensively investigate magnetization reversal properties and magnetostatic interactions of the layers at different field angles (0° ≤θ≤ 90°). These involve the extraction of several parameters, including hysteresis curve coercivity (HcHyst), FORC coercivity (HcFORC), interaction field distribution width (ΔHu), and irreversible fraction of magnetization (IFm) as a function ofθ. We find relatively constant and continuously decreasing trends ofHcHystwhen 0° ≤θ≤ 45°, and 45° < Î¸≤ 90°, respectively. Meanwhile, angular dependence ofHcFORCandIFmshows continuously increasing and decreasing trends, irrespective of the FeNi layer morphology. Our FORC results indicate the magnetization reversal properties of the FeNi/Cu nanowires are accompanied with vortex domain wall and single vortex modes, especially at high field angles. The rod-shaped layers also induce maximum ΔHuduring the reversal process, owing to enhancements in both magnetizing and demagnetizing-type magnetostatic interactions.

Molecular dynamics study of the effect of alloying elements and imperfections on linear friction welding of Cu and Ni metals.

There are many physical phenomena and properties associated with diffusion in linear friction welding (LFW) process. Many of these phenomena are not observable by known and conventional methods. The molecular dynamics (MD) is an advantageous and practical method to study the diffusion process and atomic behavior of welded materials. In the current research, we used MD simulations to model the LFW process between copper and nickel metals. The effect of defects in the structures and also the addition of alloying elements to the copper structure was also studied. Our findings revealed that the surface and subsurface imperfections in the copper structure were gradually eliminated in the friction stage. In contrast, these imperfections in nickel structure disappeared in the forging stage. Also, we showed that adding alloying elements to copper structure leads to an increase in the amount of the mean square displacement (MSD) of the atoms and the diffusion coefficient in copper.

3D interacting magnetic multilayered nanowire arrays: the emergence and evolution of new first-order reversal curve features.

The crucial role of magnetostatic interactions in tuning properties of storage devices based on magnetic nanowires (NWs) has recently been highlighted by advanced characterization techniques including the first-order reversal curve (FORC) analysis, evaluating physical entities constituting conventional 2D NW systems. Herein, FORC diagrams of ferromagnetic (FM)/non-magnetic (NM) multilayered NW arrays are simulated using Monte Carlo calculations, involving magnetostatic interactions between segments in 3D space. The FM length is constant to 6 µm whereas the NM length (L NM) varies from 10 to 300 nm, significantly influencing interwire and intrasegment interactions of neighboring NWs and coupled segments along the NW length. Intriguingly, this is accompanied with the emergence of two new FORC diagram features in addition to the typical demagnetizing-type feature, indicating complex behavior of the 3D interacting NWs with the same anisotropy field for each FM segment. The FORC coercivity of the emerging features is tracked individually, presenting evolution as a function of L NM. Our results also evidence an increase in interwire and intrasegment interactions when increasing NW diameter, being in accordance with total magnetostatic energy calculations.

Thyroid Crisis in a Patient With Burn Injury.

Thyroid crisis is an exacerbation of hyperthyroidism that results in severe systemic disturbances and could be fatal. Similarly, severe burn injury also has a hypermetabolic response as part of its presentation. When these two conditions are present concurrently, one must be cognizant that the patient requires urgent optimization of their hyperthyroid status before surgery, and continuous monitoring in an intensive care unit setting. We offer a systematic approach to managing these patients.

Electrochemical pore filling strategy for controlled growth of magnetic and metallic nanowire arrays with large area uniformity.

While a variety of template-based strategies have been developed in the fabrication of nanowires (NWs), a uniform pore filling across the template still poses a major challenge. Here, we present a large area controlled pore filling strategy in the reproducible fabrication of various magnetic and metallic NW arrays, embedded inside anodic aluminum oxide templates. Using a diffusive pulsed electrodeposition (DPED) technique, this versatile strategy relies on the optimized filling of branched nanopores at the bottom of templates with Cu. Serving the Cu filled nanopores as appropriate nucleation sites, the DPED is followed by a uniform and homogeneous deposition of magnetic (Ni and Fe) and metallic (Cu and Zn) NWs at a current density of 50 mA cm-2 for an optimal thickness of alumina barrier layer (∼18 nm). Our strategy provides large area uniformity (exceeding 400 µm2) in the fabrication of 16 µm long free-standing NW arrays. Using hysteresis loop measurements and scanning electron microscopy images, the electrodeposition efficiency (EE) and pore filling percentage (F p) are evaluated, leading to maximum EE and F p values of 91% and 95% for Ni and Zn, respectively. Moreover, the resulting NW arrays are found to be highly crystalline. Accordingly, the DPED technique is capable of cheaply and efficiently controlling NW growth over a large area, providing a tool for various nanoscale applications including biomedical devices, electronics, photonics, magnetic storage medium and nanomagnet computing.

Some Epidemiological Aspects of Cutaneous Leishmaniasis in a New Focus, Central Iran.

Following the epidemic of cutaneous leishmaniasis in Khatam County, Yazd Province, this study was carried out to determine vector, and animal reservoir host(s) and investigate the human infection during 2005-2006. Four rural districts where the disease had higher prevalence were selected. Sticky paper traps were used to collect sand flies during April to November, biweekly. Meanwhile rodents were captured using Sherman traps from August to November. Households and primary schools were visited and examined for human infection in February 2006. The parasite was detected by RAPD-PCR method. The rate of ulcers and scars among the inhabitants was 4.8% and 9.8%, respectively. Three rodent species were captured during the study: Meriones libycus, Rhombomys opimus, and Tatera indica. Six sand fly species were also collected and identified; among them Phlebotomus papatasi had the highest frequency. Leishmania major was detected as the agent of the disease in the area. It was detected from R. opimus and native people.

An ultra-sensitive impedimetric immunosensor for detection of the serum oncomarker CA-125 in ovarian cancer patients.

Effective treatment of ovarian cancer depends upon the early detection of the malignancy. Here, we report on the development of a new nanostructured immunosensor for early detection of cancer antigen 125 (CA-125). A gold electrode was modified with mercaptopropionic acid (MPA), and then consecutively conjugated with silica coated gold nanoparticles (AuNP@SiO2), CdSe quantum dots (QDs) and anti-CA-125 monoclonal antibody (mAb). The engineered MPA|AuNP@SiO2|QD|mAb immunosensor was characterised using transmission electron microscopy (TEM), atomic force microscopy (AFM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Successive conjugation of AuNP@SiO2, CdSe QD and anti-CA-125 mAb onto the gold electrode resulted in sensitive detection of CA-125 with a limit of detection (LOD) of 0.0016 U mL(-1) and a linear detection range (LDR) of 0-0.1 U mL(-1). Based on the high sensitivity and specificity of the immunosensor, we propose this highly stable and reproducible biosensor for the early detection of CA-125.

Evaluation of deltamethrin-impregnated bed nets and curtains for control of zoonotic cutaneous leishmaniasis in a hyperendemic area of Iran.

In the study carried out in the rural district of Borkhar (Isfahan, Iran) from March 2003 to March 2004 efficacy of deltamethrin impregnated bed nets (IBs) and curtains (ICs), polyester mesh size 156 holes/ inch2, (25 holes/cm2) were compared to that of non-impregnated bed nets (NIBs) and curtains (NICs), in relation to zoonotic cutaneous leishmaniasis (ZCL) control. Deltamethrin impregnated bed nets and curtains at 25 mg a.i./m2 were distributed among 168 households in one of the villages and NIBs plus NICs among the same number of households in another village. In the third village similar numbers of households were used as control. Health education messages were disseminated to ensure the population's compliance with the proper use of bed nets and curtains in the two intervention areas. Entomological surveys using sticky paper traps were carried out in ten households in each village for the collection of sand flies from indoors and outdoors, every two weeks to assess the impact of insecticide impregnated bed nets and curtains on the density of Phlebotomus papatasi. Deltamethrin susceptibility tests and also bioassay tests were carried out on this species by WHO standard method. Case findings were done by house-to-house visits once a season and all the inhabitants of the selected households in each village were examined. The results showed that IBs and ICs can provide a definite personal protection against sand fly bites and interrupted the transmission of ZCL in the intervention village. NIBs and NICs did not provide any protection against the disease. There was no significant difference in monthly density of P. papatasi in indoors and outdoors among the villages (P > 0.05). Susceptibility tests showed that this species was susceptible to deltamethrin in the field population in the area. Bioassays confirmed that the treated nets with deltamethrin remain effective for more than three months and was an excellent mean of individual protection. It is recommended that IBs and ICs can be used widely in the control of ZCL in other similar foci such as hyperendemic and mesoendemic areas of Iran.

Epidemiological study in a new focus of cutaneous leishmaniasis in the Islamic Republic of Iran.

An outbreak of cutaneous leishmaniasis (CL) in Sabzevar county prompted this study of the epidemiology and the ecology of vectors and reservoirs. Examination of 541 schoolchildren showed rates of 9.4% for scars and 5.9% for ulcers. Among 807 inhabitants of 4 villages, 10.4% had scars and 3.0% had active lesions. The most highly infected age group was 0-4 years with a rate of 5.9%. A total of 12 849 sandflies representing 7 species were collected in the study area. Leptomonad infection was found in Phlebotomus papatasi, P. caucasicus and Sergentomyia sintoni. Parasites from man, P. papatasi and Rhombomys opimus, were isolated and characterized as Leishmania major. Based on this survey, this is an epidemic of zoonotic CL, with R. opimus the main reservoir host, and P. papatasi the main vector.

Epidemiological study in a new focus of cutaneous leishmaniasis in the Islamic Republic of Iran

An outbreak of cutaneous leishmaniasis [CL] in Sabzevar county prompted this study of the epidemiology and the ecology of vectors and reservoirs. Examination of 541 schoolchildren showed rates of 9.4% for scars and 5.9% for ulcers. Among 807 inhabitants of 4 villages, 10.4% had scars and 3.0% had active lesions. The most highly infected age group was 0-4 years with a rate of 5.9%. A total of 12 849 sandflies representing 7 species were collected in the study area. Leptomonad infection was found in Phlebotomus papatasi, P. caucasicus and Sergentomyia sintoni. Parasites from man, P. papatasi and Rhombomys opimus, were isolated and characterized as Leishmania major. Based on this survey, this is an epidemic of zoonotic CL, with R. opimus the main reservoir host, and P. papatasi the main vector

Epidemiological study in a new focus of cutaneous leishmaniosis due to Leishmania major in Ardestan town, central Iran.

An endemic focus of zoonotic cutaneous leishmaniosis caused by Leishmania major zymodeme MON-26 was identified in Ardestan town central Iran, during 1998-99. Among 1960 school children examined over a 1-year period of time, 0.92% had evidence of active lesions and 1.53% had scar indicative of past infection. The incidence of the disease among school children was 3.2 per thousand in 1998. In a separate study, the incidence of infection among 100 households in an area with a population of 460 persons showed 3.26% for scars and 1.3% for ulcers. The most highly infected age group was 10-14 with a rate of 2.74%. Meriones libycus (93.3%) and Nesokia indica (6.7%) were present around the town of Ardestan. Both were found to be infected with Leishmania. Two out of 28 M. libycus (7.1%) and one out of two N. indica had positive results. M. libycus is probably the principal reservoir host of zoonotic cutaneous leishmaniosis in this area. Fourteen dogs appeared to be uninfected because examination showed no active lesion or scar. Most probably Phlebotomus papatasi is the vector because about 93% of indoor sandflies were of this species. The active season of sandflies was from late May to late October. Economic changes in this area of Iran may have contributed to this outbreak of cutaneous leishmaniosis.

Field trial for the control of zoonotic cutaneous leishmaniosis in Badrood, Iran.

BACKGROUND: Due to the resurgence of zoonotic cutaneous leishmaniosis (ZCL) in some nonendemic areas of Iran, extensive studies have been conducted on the epidemiology of the disease in different parts of the country in recent years. The objective of this study was to determine the effects of rodent control on the reduction of the incidence of ZCL in an endemic area in Badrood, Iran. PATIENTS AND METHODS: A survey was carried out in a circle around two villages between April 1997 and January 1999. The control strategy adopted in 1997 consisted of the destruction of the colonies of gerbilline rodents by digging in a radius of 500 m from houses in the intervention area. Opened burrows were baited with zinc phosphide. One village was used as control. Evaluation was made in 1998 and no other control measures were carried out in the area. Case findings were done by house-to-house visits once every season during 1997 and 1998, and all the inhabitants of the selected villages were examined. RESULTS: The average reduction of rodent holes was calculated at 87.4% one year after the first baiting in the intervention area. Changes in the number of rodent holes and the incidence of the disease in the intervention and control villages were statistically significant (P-value <0.000001). CONCLUSION: Our evaluation demonstrated that the control program reduced the incidence of ZCL 12-fold in the treated village compared to the control at the end of the first year of operation, and to more than one-fifth of its original level after two years. The results show that the field control method is very effective in destroying rodents and reducing the incidence of ZCL on a small scale and in special circumstances.