RESUMO
Covishield is in wide use in India with about 80% efficacy. Serious side effects are still under study. A 30-year-old female presented to us 7 days post-vaccination with a 5-day history of sudden diminution of vision in both eyes. The clinical findings were suggestive of the Vogt-Koyanagi-Harada (VKH) syndrome. She was treated with high-dose oral steroids. At this juncture, the association was unclear. However, it was justified by an acute flare-up of uveitis on day 2 post the second dose of vaccination despite ongoing steroids. A direct correlation of Harada-like syndrome with the Covishield vaccine is observed here.
Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos , Uveíte , Síndrome Uveomeningoencefálica , Adulto , ChAdOx1 nCoV-19 , Feminino , Humanos , Síndrome Uveomeningoencefálica/induzido quimicamente , Síndrome Uveomeningoencefálica/diagnóstico , Vacinação/efeitos adversosRESUMO
PURPOSE: To analyse the pooled safety data of intravitreal ziv-aflibercept (IVZ) therapy for various retinal conditions. METHODS: This was a retrospective, observational study which included patients from 14 participating centres who received IVZ. The medical records of patients who received IVZ from March 2015 through October 2017 were evaluated. Patient demographics and ocular details were compiled. Ocular and systemic adverse events that occurred within 1 month of IVZ injections were recorded and defined as either procedure-related or drug-related. RESULTS: A total of 1704 eyes of 1562 patients received 5914 IVZ injections (mean±SD: 3.73±3.94) during a period of 2.5 years. The age of patients was 60.6±12.8 years (mean±SD) and included diverse chorioretinal pathologies. Both ocular (one case of endophthalmitis, three cases of intraocular inflammation, and one case each of conjunctival thinning/necrosis and scleral nodule) and systemic adverse events (two cases of myocardial infarction, one case of stroke and two deaths) were infrequent. CONCLUSION: This constitutes the largest pooled safety report on IVZ use and includes patients from 14 centres distributed across the globe. It shows that IVZ has an acceptable ocular and systemic safety profile with incidences of adverse events similar to those of other vascular endothelial growth factor inhibitory drugs. The analysis supports the continued use of IVZ in various retinal disorders.
Assuntos
Receptores de Fatores de Crescimento do Endotélio Vascular/administração & dosagem , Proteínas Recombinantes de Fusão/administração & dosagem , Retina/patologia , Doenças Retinianas/tratamento farmacológico , Acuidade Visual , Relação Dose-Resposta a Droga , Feminino , Seguimentos , Humanos , Injeções Intravítreas/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Receptores de Fatores de Crescimento do Endotélio Vascular/antagonistas & inibidores , Doenças Retinianas/diagnóstico , Estudos Retrospectivos , Fatores de Tempo , Tomografia de Coerência Óptica , Resultado do TratamentoAssuntos
Extração de Catarata , Vitrectomia , Catarata , Humanos , Terapia a Laser , Implante de Lente Intraocular , Acuidade VisualAssuntos
Túnica Conjuntiva , Conjuntivite Alérgica , Algoritmos , Conjuntivite , Humanos , Índice de Gravidade de DoençaRESUMO
We present a case of a Human Immunodeficiency Virus (HIV) positive patient who was referred for retinal evaluation to rule out ophthalmic manifestations of Acquired Immunodeficiency Syndrome (AIDS). She complained of some disturbance in vision in both eyes. Fundus examination showed no abnormality. Perimetry, done to rule out optic nerve pathology, showed a left homonymous hemianopia. Magnetic Resonance Imaging (MRI) scan showed features of Progressive Multifocal Leukoencephalopathy (PML). She had no other neurological symptoms or signs.
Assuntos
Síndrome da Imunodeficiência Adquirida/complicações , Hemianopsia/diagnóstico , Leucoencefalopatia Multifocal Progressiva/diagnóstico , Diagnóstico Diferencial , Feminino , Hemianopsia/etiologia , Humanos , Leucoencefalopatia Multifocal Progressiva/complicações , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Testes de Campo VisualAssuntos
Transtornos Relacionados ao Uso de Álcool/patologia , Neurite Óptica/patologia , Neurônios Retinianos/patologia , Fumar/efeitos adversos , Tomografia de Coerência Óptica , Humanos , Fibras Nervosas/patologia , Nervo Óptico/patologia , Neurite Óptica/etiologia , Sensibilidade e EspecificidadeRESUMO
Acute transient myopia with shallowing of the anterior chamber is a rare idiosyncratic response to many systemic and topical medications, including sulfonamides. Several such cases have been reported in the past, but are less frequently reported in recent times. We report a case of acute progressive myopia and bilateral angle closure due to Topiramate--a drug used for epilepsy and migraine prophylaxis.