Randomized Manipulation of Early Cognitive Experience Impacts Adult Brain Structure.

Does early exposure to cognitive and linguistic stimulation impact brain structure? Or do genetic predispositions account for the co-occurrence of certain neuroanatomical phenotypes and a tendency to engage children in cognitively stimulating activities? Low socioeconomic status infants were randomized to either 5 years of cognitively and linguistically stimulating center-based care or a comparison condition. The intervention resulted in large and statistically significant changes in brain structure measured in midlife, particularly for male individuals. These findings are the first to extend the large literature on cognitive enrichment effects on animal brains to humans, and to demonstrate the effects of uniquely human features such as linguistic stimulation.

Mental Health and Social Development Effects of the Abecedarian Approach.

The Abecedarian Approach is an early intervention and contains a broad-spectrum adult/child curriculum. The Approach has been studied in three longitudinal randomized controlled trials in the USA, starting in 1972 and continuing today. Recent research studies in multiple countries have examined the Abecedarian Approach during the first three years of life. The collective findings from these studies lead to the conclusion that human development is malleable, especially in the years before school entry, and that high-quality early intervention exerts positive, early, and long-lasting influences on human development, including social development and mental health.

Early childhood investment impacts social decision-making four decades later.

Early childhood educational investment produces positive effects on cognitive and non-cognitive skills, health, and socio-economic success. However, the effects of such interventions on social decision-making later in life are unknown. We recalled participants from one of the oldest randomized controlled studies of early childhood investment-the Abecedarian Project (ABC)-to participate in well-validated interactive economic games that probe social norm enforcement and planning. We show that in a repeated-play ultimatum game, ABC participants who received high-quality early interventions strongly reject unequal division of money across players (disadvantageous or advantageous) even at significant cost to themselves. Using a multi-round trust game and computational modeling of social exchange, we show that the same intervention participants also plan further into the future. These findings suggest that high quality early childhood investment can result in long-term changes in social decision-making and promote social norm enforcement in order to reap future benefits.

Correction to: The Abecedarian Approach to Social, Educational, and Health Disparities.

In the section "Ages 39-45 Outcomes," an error was made by providing details from my ongoing collaborative research with colleagues on neuroanatomical effects (Farah et al 2017) and social decision-making (Luo et al 2017).

The Abecedarian Approach to Social, Educational, and Health Disparities.

This paper places the Abecedarian Approach in theoretical and historical context and reviews the results from three randomized controlled trials that have tested an experimental protocol designed to prevent cognitive disabilities and their social consequences. Results affirm that cognitive disabilities can be prevented in early childhood and subsequent academic achievement enhanced via a multipronged comprehensive approach that contains individualized and responsive early childhood education starting in early infancy, coupled with pediatric health care, good nutrition, and family-oriented social services. Additional important findings reveal that the most vulnerable children benefited the most and that cognitive gains were not at the expense of children's socioemotional development or relationship to family. In general, mothers derived benefits in education and employment and teenage mothers especially benefited from their children participating in the early education treatment group. On the whole, the overall pattern of results supports a multidisciplinary, individualized, and long-term longitudinal perspective on human development and prevention science. Recent structural and functional brain imaging in the fifth decade of life shows persistent effects of intensive early educational treatment. Independent recent cost-benefit analysis in adulthood reveals a 7.3:1 return on investment with a 13.7% average annual rate of return. The paper concludes with a discussion of implications of the Abecedarian Approach to today's high-risk population in the USA.

Graphically characterizing the movement of a rabid striped skunk epizootic across the landscape in northwestern Wyoming.

A striped skunk (Mephitis mephitis) rabies epizootic in northwestern Wyoming was studied from the Index Case in 1988 to the last case in 1993, and possibly is the first rabies epizootic in a previously rabies-free zone monitored from beginning to end. The 843 km(2) study area comprised skunk habitat along 90 km of Shoshone River's floodplain from Bighorn Lake upstream to Cody. Of 1,015 skunks tested, 215 were rabies-positive. Integrating spatial and temporal data from positive cases, we analyzed the epizootic's movements and dynamics at 6-month intervals using multivariate movement maps, a new multivariate descriptive methodology presented here to demonstrate the epizootic's directional flow, while illustrating areas with higher case densities (i.e., wave crests). This approach should help epidemiologists and public health officials to better understand future rabies epizootics.

Adult outcomes as a function of an early childhood educational program: an Abecedarian Project follow-up.

Adult (age 30) educational, economic, and social-emotional adjustment outcomes were investigated for participants in the Abecedarian Project, a randomized controlled trial of early childhood education for children from low-income families. Of the original 111 infants enrolled (98% African American), 101 took part in the age 30 follow-up. Primary indicators of educational level, economic status, and social adjustment were examined as a function of early childhood treatment. Treated individuals attained significantly more years of education, but income-to-needs ratios and criminal involvement did not vary significantly as a function of early treatment. A number of other indicators were described for each domain. Overall, the findings provide strong evidence for educational benefits, mixed evidence for economic benefits, and little evidence for treatment-related social adjustment outcomes. Implications for public policy are discussed.

Early educational intervention, early cumulative risk, and the early home environment as predictors of young adult outcomes within a high-risk sample.

The extent to which early educational intervention, early cumulative risk, and the early home environment were associated with young adult outcomes was investigated in a sample of 139 young adults (age 21) from high-risk families enrolled in randomized trials of early intervention. Positive effects of treatment were found for education attainment, attending college, and skilled employment; negative effects of risk were found for education attainment, graduating high school, being employed, and avoiding teen parenthood. The home mediated the effects of risk for graduating high school, but not being employed for teen parenthood. Evidence for moderated mediation was found for educational attainment; the home mediated the association between risk and educational attainment for the control group, but not the treated group.

Injury risk among children of low-income U.S.-born and immigrant mothers.

The number of immigrants in the United States is at an all time high, yet psychologists have largely ignored the domain of immigrant health. This article considers 1 aspect of immigrant health, risk for pediatric injury. A sample of over 5,000 5-year-old children from impoverished families was studied; approximately 13% had immigrant mothers. Children of immigrants had a significantly lower rate of injury in the prior year. This was particularly true of non-White children of immigrants. Three possible mediators for this finding--assistance with parenting, parenting style, and health care accessibility--were considered, but none explained the difference. The need for further research on the topic and implications of results for injury prevention are discussed.

Interactions between child behavior patterns and parenting: implications for children's unintentional injury risk.

OBJECTIVES: Two factors were considered as predictors of children's risk for unintentional injury: (a) children's temperamentally difficult behavior patterns and (b) parenting. Along with hypotheses to replicate previous univariate effects, it was hypothesized that active, involved parents with sufficient time resources might reduce injury risk among temperamentally at-risk children. METHODS: Study 1 used a retrospective design with a diverse sample of over 10,000 5-year-olds. Study 2 replicated Study 1 using a prospective design and behavioral data from a sample of over 1,000 children followed from 6 to 36 months of age. RESULTS: In Study 1, male gender, child hyperactivity, and family poverty predicted injury in a univariate manner. In Study 2, male gender and lack of positive parenting predicted injury in a univariate manner. Interaction effects also emerged: in Study 1 the interaction between child hyperactivity and parental time resources protected children from injury, and in Study 2 the interaction between child's difficult temperament and positive parenting protected children from injury. CONCLUSIONS: Children at increased risk for injury, i.e., those with hyperactive and difficult behavior patterns, might be protected in the environment of positive parenting. Theoretically, results suggest that researchers should consider Temperament x Environment interactions along with univariate predictors of outcome behavior. From an applied perspective, results have implications for the design of injury prevention campaigns: Parents who spend positive time with temperamentally difficult children might protect them from injury.

An index technique to monitor broadcast calibration and bait pick up, plus rodent and avian sign under arid conditions.

As part of product-performance and wildlife-hazards studies of 2% zinc phosphide (Zn3P2) steam-rolled-oat baits (11.2 kg ha-1) to reduce vole populations (Microtus spp) in alfalfa (Medicago sativa), we used randomly located, brushed-dirt plots (eight approximately 930-cm2 plots per 0.2-ha enclosure) to monitor bait-broadcast and -removal patterns, as well as to index vole and avian sign. Research was conducted in 18 x 0.2-ha enclosures containing 2.5-year-old stands of alfalfa; a 2-day pre-bait (placebo baits broadcast in all enclosures) period followed by a 14-day test-bait period (placebo and 2% Zn3P2 baits in nine enclosures each) characterized the bait exposures. Baits were broadcast manually by two certified pesticide applicators (CPAs) using Spyker Model-75 spreaders. Baits that fell onto plots were counted < 30 min later to assess the uniformity of bait distribution. The main statistical design was a 2 (placebo or Zn3P2 baits) x 3 (vole-only, vole-pheasant, vole-quail exposures) x 14 (days) factorial, with days considered repeated measurements. In the six vole-only enclosures, baits were removed from the brushed-dirt plots and replaced with four 0% or 2% Zn3P2 baits (one per 232.6-cm2 quadrant; 32 per enclosure); these 'placed' baits were then monitored daily for removal, while the surfaces of all plots were monitored daily for the presence:absence of animal/bird sign. Key results were: (a) 3.51 (+/- 2.66) and 3.39 (+/- 3.52) mean (+/- SD) baits were found on plots after pre-bait and test-bait broadcasts, respectively--less than the predicted 4.52 particles per 930-cm2 plot; (b) baits 'placed' on plots in placebo-baited enclosures were removed earlier than those in Zn3P2-baited enclosures--data in agreement with observed vole mortality; and (c) species x bait interactions occurred for both the vole- and pheasant-sign counts, but not quail-sign counts--data also indirectly confirming Zn3P2-induced mortality effects on voles and pheasants. This technique has utility for a variety of wildlife biology and chemical registration studies; although limited to arid conditions, the technique affords useful indices of broadcast calibration, bait pick-up, as well as target and non-target species mortality.

Early Intervention and Mediating Processes in Cognitive Performance of Children of Low-Income African American Families.

This longitudinal study of 161 African American children from low-income families examined multiple influences, including early childhood interventions and characteristics of the child and family, on longitudinal patterns of children's cognitive performance measured between 6 months and 8 years of age. Results indicate that more optimal patterns of cognitive development were associated with intensive early educational child care, responsive stimulating care at home, and higher maternal IQ. In accordance with a general systems model, analyses also suggested that child care experiences were related to better cognitive performance in part through enhancing the infant's responsiveness to his or her environment. Maternal IQ had both a direct effect on cognitive performance during early childhood and, also, an indirect effect through its influence on the family environment.

Power Calculations for General Linear Multivariate Models Including Repeated Measures Applications.

Recently developed methods for power analysis expand the options available for study design. We demonstrate how easily the methods can be applied by (1) reviewing their formulation and (2) describing their application in the preparation of a particular grant proposal. The focus is a complex but ubiquitous setting: repeated measures in a longitudinal study. Describing the development of the research proposal allows demonstrating the steps needed to conduct an effective power analysis. Discussion of the example also highlights issues that typically must be considered in designing a study. First, we discuss the motivation for using detailed power calculations, focusing on multivariate methods in particular. Second, we survey available methods for the general linear multivariate model (GLMM) with Gaussian errors and recommend those based on F approximations. The treatment includes coverage of the multivariate and univariate approaches to repeated measures, MANOVA, ANOVA, multivariate regression, and univariate regression. Third, we describe the design of the power analysis for the example, a longitudinal study of a child's intellectual performance as a function of mother's estimated verbal intelligence. Fourth, we present the results of the power calculations. Fifth, we evaluate the tradeoffs in using reduced designs and tests to simplify power calculations. Finally, we discuss the benefits and costs of power analysis in the practice of statistics. We make three recommendations: Align the design and hypothesis of the power analysis with the planned data analysis, as best as practical.Embed any power analysis in a defensible sensitivity analysis.Have the extent of the power analysis reflect the ethical, scientific, and monetary costs. We conclude that power analysis catalyzes the interaction of statisticians and subject matter specialists. Using the recent advances for power analysis in linear models can further invigorate the interaction.