[Primary immunoproliferative small intestinal disease]. / Enfermedad inmunoproliferativa primaria del intestino delgado (IPSID).

We report two cases of Primary small Intestinal Lymphoma (IPSID), in adults. The clinical presentation was, watery diarrhea and weight loss. The histology of this cases was non-Hodgkin's Lymphoma, and the treatment was chemotherapy.

[Changes in the natural history of peptic ulcer after Helicobacter pylori eradication. Randomized, double-blind, placebo controlled trial. Follow-up of 44 months]. / Cambio de la historia natural de la ulcera duodenal después de la erradicacíon de Helicobacter pyroli. Estudio aleatório, doble ciego, controlado con placebo. Seguimiento de 44 meses.

We included 63 patients (p) with duodenal ulcer and Helicobacter pylori infection to be treated with Famotidine 40mg/day for six weeks. In the first ten days one group of 33p (TG) received Metronidazole 250mg plus Amoxicillin 500mg T.I.D and 30p (PG) placebo. Helicobacter pylori was eradicated in 62.5% of TG. Infection was always associated with ulcer recurrence. Healing was similar in both groups but recurrence was statistically significant after three month in PG and in the first year all Pg had relapsed. At 44 month only 25% of TG relapsed. The natural history of peptic ulcer disease was changed with Helicobacter pylori eradication.

[Portal hypertensive gastropathy: histologic and endoscopic correlation]. / Gastropatía portal hipertensiva: correlación endoscópico histológica.

Portal Hypertensive Gastropathy (PHG) diagnosed in 42 patients by upper gastrointestinal endoscopy and was correlated with histological findings of gastric biopsies taken from fundus-body and antrum and observed blinded by the pathologist. We found that in the fundus PHG was observed in 97.14% and of these 77.14% were mosaic pattern. Submucosal vessel dilatation was observed in 65.71%, congestion in 60% and chronic gastritis in 62.85%. Histologic and endoscopic correlation was possible in 85.71%. Our results show a histologic and endoscopic correlation.

[The recurrence of duodenal ulcer after treatment for Helicobacter pylori. A randomized, double-blind, placebo-controlled study]. / Recurrencia de la úlcera duodenal después del tratamiento de Helicobacter pylori. Estudio randomizado, doble ciego, controlado con placebo.

We studied 63 duodenal ulcer (DU) patients (p) diagnosed by upper gastrointestinal endoscopy (UGE) and Helicobacter pylori positive (HP). Patients were randomized, double-blinded to receive placebo (PG) 30p or Amoxicillin plus Metronidazole 33p (TG). All of them took Famotidine for six weeks and at this point UGE was performed. DU healing was similar in both groups. HP eradication was possible in 14/24p of TG and 4/23 of PG (58.33% vs 17.39%) difference was statistically significant. DU recurrence at 3 months was 68.75% in PG vs 11.76% in TG (p = 0.001). At the end point of the study global recurrence of DU was 3/24p in TG vs 19/23 in PG (p = 0.000001). Our findings suggest that DU recurrence is related to the presence of HP. Definitive treatment to permanently eradicate the bacteria is to be evaluated.

[The urease test for the diagnosis of Campylobacter pylori infection]. / Prueba de la ureasa para el diagnóstico de infección por Campylobacter pylori.

To evaluate the usefulness of urea media routinely applied in the diagnosis of Campylobacter pylori infection, 50 patients with gastroduodenal pathology were studied. Two biopsies of antral mucosa were taken; one of them was placed on Urea Agar Base (Difco) prepared without agar, and the other in saline for Gram staining and culture in selective and enriched media. In 39 patients Campylobacter pylori was found by Gram staining and/or culture. 38 of them were urease test positive, 24 (61.5%) during the first hour, 8 (20.5%) between the first and fourth hours and 6 (15.3%) between 4 and 24 hours. The sensitivity of the test increased from 61.5% at the first hour to 82.0% and 97.3% at 4 and 24 hours, respectively. The specificity was 100% for all the readings. We believe that the urease test with medium of Urea Agar Base is useful for the diagnosis of Campylobacter pylori infection. However, we recommend the selection of two or three combined methods for better confirmation of the infection.