1.
Org Biomol Chem
; 15(1): 82-87, 2016 Dec 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27901164
RESUMO
TFA alone was found to be remarkably effective for the intramolecular hydroarylation (IMHA) of alkynes when employed as a solvent in the cyclization of 3-alkynyl substituted 2-(indol-3-yl)quinoxalines. This simple and metal free cyclization method afforded a range of indolophenazines as new and potential cytotoxic agents. The use of excess TFA was found to be crucial for the success of this reaction.