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1.
Polymers (Basel) ; 15(3)2023 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-36771918

RESUMO

With the improvement of protection technology, the damage power of conventional penetrators has become increasingly inferior. Reactive material is a new type of energetic material, which has strong energy release capabilities under high-velocity-impact conditions. In this paper, the reactive materials were put into the penetrator, and its penetration characteristics were studied. First, the penetrator with enhanced lateral effect (PELE) projectile structure with better penetration capability was obtained by numerical simulation. Then, based on the established polytetrafluoroethylene (PTFE)/Al reactive material reaction model, the numerical simulation and experimental research of the PELE projectile with a reactive inner core penetrating the target were carried out. The results show that the simulation results are in good agreement with the experimental results, which verifies the confidence of the numerical simulation. The PELE projectile had a significant increase in power with the use of a truncated conical head and reactive materials. The residual velocity of the truncated cone PELE projectile increases by 8.41-21% over conventional PELE projectiles. Its damage range is 43% higher than that of conventional penetrators. The simulation method and the conclusions obtained in this paper can provide support and reference for further research on reactive materials and on effectively improving the damage power of the penetrator.

2.
Cell Mol Life Sci ; 79(6): 311, 2022 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-35598196

RESUMO

The inflammatory response of macrophages has been reported to play a critical role in atherosclerosis. The inflammatory state of macrophages is modified by epigenetic reprogramming. m6A RNA methylation is an epigenetic modification of RNAs. However, little is known about the potential roles and underlying mechanisms of m6A modification in macrophage inflammation. Herein, we showed that the expression of the m6A modification "writer" Mettl14 was increased in coronary heart disease and LPS-stimulated THP-1 cells. Knockdown of Mettl14 promoted M2 polarization of macrophages, inhibited foam cell formation and decreased migration. Mechanistically, the expression of Myd88 and IL-6 was decreased in Mettl14 knockdown cells. Through m6A modification, Mettl14 regulated the stability of Myd88 mRNA. Furthermore, Myd88 affected the transcription of IL-6 via the distribution of p65 in nuclei rather than directly regulating the expression of IL-6 through m6A modification. In vivo, Mettl14 gene knockout significantly reduced the inflammatory response of macrophages and the development of atherosclerotic plaques. Taken together, our data demonstrate that Mettl14 plays a vital role in macrophage inflammation in atherosclerosis via the NF-κB/IL-6 signaling pathway, suggesting that Mettl14 may be a promising therapeutic target for the clinical treatment of atherosclerosis.


Assuntos
Aterosclerose , Macrófagos , Metiltransferases , NF-kappa B , Aterosclerose/genética , Aterosclerose/metabolismo , Humanos , Inflamação/genética , Inflamação/metabolismo , Interleucina-6/genética , Interleucina-6/metabolismo , Macrófagos/metabolismo , Metiltransferases/genética , Metiltransferases/metabolismo , Fator 88 de Diferenciação Mieloide/genética , NF-kappa B/genética , NF-kappa B/metabolismo , Transdução de Sinais , Células THP-1
3.
Materials (Basel) ; 14(13)2021 Jun 22.
Artigo em Inglês | MEDLINE | ID: mdl-34206650

RESUMO

Recent studies have shown that the energy release capacity of Polytetrafluoroethylene (PTFE)/Al with Si, and CuO, respectively, is higher than that of PTFE/Al. PTFE/Al/Si/CuO reactive materials with four proportions of PTFE/Si were designed by the molding-sintering process to study the influence of different PTFE/Si mass ratios on energy release. A drop hammer was selected for igniting the specimens, and the high-speed camera and spectrometer systems were used to record the energy release process and the flame spectrum, respectively. The ignition height of the reactive material was obtained by fitting the relationship between the flame duration and the drop height. It was found that the ignition height of PTFE/Al/Si/CuO containing 20% PTFE/Si is 48.27 cm, which is the lowest compared to the ignition height of other Si/PTFE ratios of PTFE/Al/Si/CuO; the flame temperature was calculated from the flame spectrum. It was found that flame temperature changes little for the same reactive material at different drop heights. Compared with the flame temperature of PTFE/Al/Si/CuO with four mass ratios, it was found that the flame temperature of PTFE/Al/Si/CuO with 20% PTFE/Si is the highest, which is 2589 K. The results show that PTFE/Al/Si/CuO containing 20% PTFE/Si is easier to be ignited and has a stronger temperature destruction effect.

4.
Materials (Basel) ; 13(1)2019 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-31877758

RESUMO

Metal/fluoropolymer materials are typical reactive materials. Polytetrafluoroethylene (PTFE)/Al/CuO reactive materials were studied in this research. Scanning electron microscopy (SEM), quasi-static compression, the Split Hopkinson pressure bar test, and the drop hammer test were used to study the mechanical properties and induced reaction characteristics of the reactive materials with different Al/CuO thermite contents and different particle sizes. SEM images of the samples demonstrate that the reactive materials were mixed evenly. The compression test results show that, if the particle size of PTFE was too small, the strength of reactive materials after sintering was reduced. After sintering, with the increase in the content of Al/CuO thermite, the strength of the micro-sized PTFE/Al/CuO firstly increased and then decreased. The Johnson-Cook constitutive model can be used to characterize the reactive materials, and the parameters of the Johnson-Cook constitutive model of No. 3 reactive materials (PTFE/Al:Al/CuO = 3:1) were obtained. The reliability of the parameters was verified by numerical simulation. Drop hammer tests show that the addition of Al/CuO aluminothermic materials or the use of nano-sized PTFE/Al reactive materials can significantly improve the sensitivity of the material. The research in this paper can provide a reference for the preparation, transportation, storage, and application of reactive materials.

5.
Materials (Basel) ; 12(23)2019 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-31795111

RESUMO

Currently, PTFE/Al is widely used in the reactive fragmentation warhead. However, for the same explosive yield, the reactive fragments usually have a smaller damage-radius than the inert fragments because PTFE/Al has a poor penetration ability and needs an impact-speed up to 1000 m/s to stimulate its chemical reaction. To enhance the damage power of reactive fragments, six kinds of reactive materials (PTFE/Al, PTFE/B, PTFE/Si, PTFE/Al/B, PTFE/Al/Si, and PTFE/Al/CuO) based on PTFE were designed and studied. Through the drop weight system and the self-designed energy release test device, qualitative and quantitative analysis of the energy release ability of six kinds of reactive materials were carried out. The qualitative analysis results indicate that the reactions of PTFE/B and PTFE/Si are weak under the impact of drop hammer with only a very weak fire light produced, while the reactions of PTFE/Al, PTFE/Al/B, PTFE/Al/Si, and PTFE/Al/CuO are relatively intense, and the reaction of PTFE/Al/Si is the most intense. Through the self-designed energy release test device, the energy release ability of the reactive material was quantitatively compared and analyzed. The results show that the energy release ability of the four formulations were as follows: PTFE/Al/Si > PTFE/Al/CuO > PTFE/Al/B > PTFE/Al. Therefore, it can be concluded that the PTFE/Al/Si formulation is a new reactive material with strong energy release ability, which can be a new choice for reactive fragment.

6.
Polymers (Basel) ; 11(1)2019 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-30960133

RESUMO

Metal/polymer reactive materials have been studied and applied in a wide range of ways in recent years. This type of material is insensitive under normal conditions but reacts violently and releases a large amount of chemical energy under high-speed impact or high strain rate loading conditions. Compared with conventional explosives, it has better mechanical properties, and its unit mass energy is several times that of TNT. In this paper, PTFE/Al/CuO reactive materials are the main research objects, and we assess the impact energy release abilities of this type of reactive material through experimental research. To this end, eight sets of material formulations are designed, and the effects of particle size, the ratio of PTFE/Al and Al/CuO materials, and sintering on the energy release ability of the reactive materials are investigated. All experiments are carried out based on a self-designed new energy release testing device. The experimental device can measure the pressure time history curve generated by the reactive materials, and the rationality of the pressure time history curve can also be verified by the displacement time curve of the piston. The results show that with an increase in the Al/CuO thermite content, the energy release rate of the reactive material clearly increases, which is attributed to the reaction threshold of Al/CuO being low and because the heat generated can promote the reaction of PTFE/Al. The energy release rate of the nano-scale reactive materials is higher than that of the micron-scale reactive materials because the reduction in particle size results in a larger specific surface area. Thus, the energy required for ignition is lower. The energy release rate of sintered reactive materials is higher than that of unsintered reactive materials, which can be explained by the interfacial area between Al particles and PTFE particles in sintered reactive materials being larger, which makes the reaction more sufficient. The self-designed energy release testing device for the reactive materials and the conclusions obtained in this paper have clear significance for guiding engineering applications.

7.
Materials (Basel) ; 11(12)2018 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-30486454

RESUMO

The PELE (penetration with enhanced lateral efficiency) projectile is a new type of safe ammunition which can form a large number of fragments after perforating the target, and does not depend on any pyrotechnics. The damage characteristics of PELE projectile mainly include the penetration ability and fragmentation effect. There are many factors affecting the damage characteristics of PELE projectile, and this paper attempts to study the damage characteristics of PELE projectile, from the point of view of changing the single core material. Therefore, four different inner core combination types were designed in this paper, namely, zero gradient-I type (PE), zero gradient-II type (Al), positive gradient type (PE + Al), and negative gradient type (Al + PE). With the help of a more mature numerical simulation method, the studies were carried out from several aspects, such as the axial residual velocity of projectile, the radial scattering velocity of fragments, the radial scattering radius of fragments, and the residual length of projectile. The axial residual velocity of projectile can characterize the penetration ability of projectile, the radial scattering velocity and radial scattering radius of fragments can predict the damage area of fragments, and the residual length of projectile can reflect the fragment conversion rate of casing. The results indicate that the negative gradient inner core combination is superior to the other three combinations in terms of the penetration ability and fragmentation effect. Under the same impact velocity, the maximum radial velocity and radial scattering radius of fragments mainly depend on the front inner core material, and these two parameters will increase appropriately with the increase of the strength of front inner core material. Similarly, the residual length of projectile can be reduced, or the fragment conversion rate can be enhanced, by properly reducing the strength of rear inner core material. The conclusions obtained in this paper can provide a reference for engineering applications.

8.
Materials (Basel) ; 11(9)2018 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-30200176

RESUMO

In order to more realistically reflect the penetrating and crushing process of a PELE (Penetration with Enhanced Lateral Efficiency) projectile, the stochastic failure algorithm and crack-softening algorithm were added to the corresponding material in this paper. According to the theoretical analysis of the two algorithms, the material failure parameters (stochastic constant γ, fracture energy Gf, and tensile strength σT) were determined. Then, four sets of simulation conditions ((a) no crack softening, (b) no stochastic failure, (c) no crack softening and no stochastic failure, and (d) crack softening and stochastic failure) were designed to qualitatively describe the influences of the failure algorithms, which were simulated by the finite element analysis software AUTODYN. The qualitative comparison results indicate that the simulation results after adding the two algorithms were closer to the actual situation. Finally, ten groups of simulation conditions were designed to quantitatively analyze the coincidence degree between the simulation results and the experimental results by means of two parameters: the residual velocity of the projectile and the maximum radial velocity of fragments. The results show that the simulation results coincide well with the experimental results and the errors were small. Therefore, the ideas proposed in this paper are scientific, and the conclusions obtained can provide guidance for engineering research.

9.
Materials (Basel) ; 11(1)2018 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-29300351

RESUMO

The shaped charge tandem warhead is an effective weapon against the ERA (explosive reactive armor). Whether the pre-warhead can reliably initiate the ERA directly determines the entire performance of the tandem warhead. The existing shaped charge pre-warhead mostly adopts a metal shaped jet, which effectively initiates the ERA, but interferes the main shaped jet. This article, on the other hand, explores the possibility of producing a pre-warhead using a low-density material as the liner. The nonlinear dynamic analysis software Autodyn-2D is used to simulate and compare three kinds of low-density shaped jets, including floatglass, Lucite, and Plexiglas, to the copper shaped jet in the effectiveness of impacting ERA. Based on the integrative criteria (including u-d initiation criterion, explosive reactive degree, explosive pressure, and particle velocity of the panels), it can be determined whether the low-density shaped jet can reliably initiate the sandwich charge. The results show that the three kinds of low-density shaped jets can not only initiate the reaction armor, but are also superior to the existing copper shaped jet in ductility, jet tip velocity, jet tip diameter, and the mass; namely, it is feasible to use the low-density material shaped jet to destroy the ERA.

10.
Phys Rev E ; 94(6-1): 062906, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28085334

RESUMO

We use a discrete-element method simulation and analytical considerations to study the dynamics of a self-energized object, modeled as a disk, oscillating horizontally within a two-dimensional bed of denser and smaller particles. We find that, for given material parameters, the immersed object (IO) may rise, sink, or not change depth, depending on the oscillation amplitude and frequency, as well as on the initial depth. With time, the IO settles at a specific depth that depends on the oscillation parameters. We construct a phase diagram of this behavior in the oscillation frequency and velocity amplitude variable space. We explain the observed rich behavior by two competing effects: climbing on particles, which fill voids opening under the disk, and sinking due to bed fluidization. We present a cavity model that allows us to derive analytically general results, which agree very well with the observations and explain quantitatively the phase diagram. Our specific analytical results are the following. (i) Derivation of a critical frequency, f_{c}, above which the IO cannot float up against gravity. We show that this frequency depends only on the gravitational acceleration and the IO size. (ii) Derivation of a minimal amplitude, A_{min}, below which the IO cannot rise even if the frequency is below f_{c}. We show that this amplitude also depends only on the gravitational acceleration and the IO size. (iii) Derivation of a critical value, g_{c}, of the IO's acceleration amplitude, below which the IO cannot sink. We show that the value of g_{c} depends on the characteristics of both the IO and the granular bed, as well as on the initial IO's depth.

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