RESUMO
BACKGROUND: Residual ridge resorption presents obstacles in prosthodontic treatment, affecting denture stability and the success of dental implants. Genetic elements, specifically the single nucleotide polymorphism (SNP) 1772C>T variant within the hypoxia-inducible factor 1 subunit alpha (HIF-1α) gene, are hypothesized to contribute to residual ridge resorption progression. Nevertheless, its impact remains insufficiently investigated, especially within the context of South Indian populations. We sought to investigate the connection between SNP 1772C>T and residual ridge resorption (RRR) among fully edentulous individuals, considering demographic factors, genotyping methodologies, and statistical evaluations. METHODS: In a prospective case-control study, we recruited 100 completely edentulous participants from South India. Participants were categorized based on alveolar ridge height. Saliva samples were non-invasively collected for DNA extraction, and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was employed to determine genotype distribution using the HphI restriction enzyme. The statistical evaluations comprised the utilization of chi-square and Fisher's exact tests. RESULTS: We observed no significant variations in genotype distributions between the case and control cohorts (CT: p=0.24; CC: p=0.65; TT: p=0.30). The heterozygous genotype CT was prevalent in both groups. CONCLUSIONS: Although we did not observe significant associations between SNP 1772C>T and RRR, our findings imply a genetic predisposition to residual ridge resorption that warrants further exploration. Variations in genetic susceptibility across ethnicities and the influence of other genetic variants on residual ridge resorption require additional investigation. This study lays the groundwork for personalized prosthodontic care by highlighting the potential of genetic analysis in routine dental practice to improve treatment strategies.
RESUMO
Aim: The intention was to determine the chemical interaction of silanized AgNPs with PMMA by Fourier transform infrared (FTIR) spectroscopy. Settings and Design: In-vitro comparative study. Materials and Methods: This study is composed of four groups - 0.75% AgNP, 1.0% AgNP, 1.5% AgNP impregnated with PMMA, and nonimpregnated PMMA as control. The chemical nature of silanized AgNPs was studied using FTIR study. Results: The results showed the appearance of new peak between 1727/cm and 1436/cm, i.e., 1636.476/ cm, 1645.886/cm, and 1646.885/cm, representing the C = C stretch in the experimental groups, i.e., 2, 3, and 4, respectively. This peak confirms that coupling agent has chemically interacted with PMMA. Conclusion: It can be concluded that the AgNPs coated with the silane coupling agent TMSPM has chemically reacted with PMMA.