Estudo comparativo do padrão de crescimento entre as análises USP, Ricketts, McNamara e Jarabak / Comparative study of growth standart among the USP, Ricketts, McNamara and Jarabak

Objetivo: o objetivo desse estudo foi comparar o diagnóstico de quatro grandezas cefalométricas rotineiramente utilizadas na determinação do padrão de crescimento craniofacial e verificar a possibilidade, ou não, de concordância entre elas. Métodos: a amostra foi composta por 30 telerradiografias laterais de indivíduos brasileiros, sendo 18 do sexo feminino e 12 do sexo masculino, com idade média de 21 anos. As análises cefalométricas avaliadas foram USP, Ricketts, McNamara e Jarabak. Para obtenção das grandezas NS.Gn (padrão USP), AFAI (padrão McNamara), Eixo Facial (padrão Ricketts) e Percentual S-Go/N-Me (padrão Jarabak), foi usado o software Radiocef 4.0. Conclusão: para os braquicefálicos a análise de Jarabak apresenta o maior percentual e difere apenas da análise de Ricketts (0%). Nos dolicocefálicos, Jarabak foi diferente de todos os demais testes e nos mesocefálicos não existem diferenças estatísticas para os testes, mesmo entre McNamara e Ricketts, apresentando o valor de 20%.

Homogenous amniotic membrane as a biological dressing for oral mucositis in rats: histomorphometric analysis.

OBJECTIVE: Oral mucositis is a frequent and significant side effect of chemotherapy and/or radiation therapy. The purpose of this study was to evaluate the effects of the homogenous amniotic membrane (HAM) as a biological dressing for oral mucositis induced by 5-fluorouracil (5-FU) in the labial fornix region of inferior incisors in rats. METHODS: Sixty rats were divided into three groups: control (50% acetic acid), 5-FU (50% acetic acid and 5-fluorouracil-induced oral mucositis) and 5-FU+HAM (50% acetic acid and 5-fluorouracil-induced oral mucositis, and treated with HAM). Histological analyses were done 3, 7, 14 and 21 days after applying the acetic acid. RESULTS: HAM showed not only no signs of rejection as well as an excellent tissue adherence to the ulcerated surface. Histomorphometric analysis indicated a lower quantity of inflammatory cells in the 5-FU+HAM group in all periods when compared to the other groups and there was a statistically significant difference in the 3- and 7-day periods (P<0.001). CONCLUSIONS: The results of this study suggest that HAM was biocompatible with great adhesive power to the ulcerated surface, accelerated the healing process and exhibited anti-inflammatory activity. Further studies should be done to investigate the potential benefits of this material in clinical trials. HAM could lead to improved results as a biological dressing in treatment and management of oral mucositis in patients submitted to chemotherapy and/or radiation therapy.

Familial malignant osteopetrosis in children: a case report.

The clinical, radiological, pathological and laboratory findings of two brothers with autosomal recessive malignant osteopetrosis are presented. Our findings are similar to characteristics previously reported in the literature about patients with osteopetrosis. The 6-year-old male patient was pale and had petechiae on his arms and legs. He also had macrocephalia, splenomegaly, severe pancytopenia, genu valgus, hypocalcemia, amaurosis, cessation of physical development, generalized bone sclerosis and recurrent infections with a history of multiple incidences of acute otitis media. Generalized bone sclerosis and irregular sclerosis of the maxilla and mandible were seen on radiographs. The oral mucosa was apparently normal but permanent tooth eruption was delayed although there was early loss of deciduous teeth. The recommended treatment was blood transfusion and therapy with antibiotics when necessary; a bone marrow transplant was not possible due to lack of a compatible donor.