Intelligent modeling of hydrogen sulfide solubility in various types of single and multicomponent solvents.

This study aims to study the solubility of acid gas, i.e., hydrogen sulfide (H2S) in different solvents. Three intelligent approaches, including Multilayer Perceptron (MLP), Gaussian Process Regression (GPR) and Radial Basis Function (RBF) were used to construct reliable models based on an extensive databank comprising 5148 measured samples from 54 published sources. The analyzed data cover 95 single and multicomponent solvents such as amines, ionic liquids, electrolytes, organics, etc., in broad pressure and temperature ranges. The proposed models require just three simple input variables, i.e., pressure, temperature and the equivalent molecular weight of solvent to determine the solubility. A competitive examination of the novel models implied that the GPR-based one gives the most appropriate estimations with excellent AARE, R2 and RRMSE values of 4.73%, 99.75% and 4.83%, respectively for the tested data. The mentioned intelligent model also performed well in describing the physical behaviors of H2S solubility at various operating conditions. Furthermore, analyzing the William's plot for the GPR-based model affirmed the high reliability of the analyzed databank, as the outlying data points comprise just 2.04% of entire data. In contrast to the literature models, the newly presented approaches proved to be applicable for different types of single and multicomponent H2S absorbers with AAREs less than 7%. Eventually, a sensitivity analysis based on the GPR model reflected the fact that the solvent equivalent molecular weight is the most influential factor in controlling H2S solubility.

Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10/TNF-α ratio in skeletal muscle of 4T1 breast cancer mice with cachexia.

Cancer cachexia is characterized by inflammation, loss of skeletal muscle and adipose tissue mass, and functional impairment. Oxidative stress and inflammation are believed to regulate pathways controlling skeletal muscle wasting. The aim of this study was to determine the effects of aerobic interval training and the purported antioxidant treatment, selenium nanoparticle supplementation, on expression of IL-15 and inflammatory cytokines in 4T1 breast cancer-bearing mice with cachexia. Selenium nanoparticle supplementation accelerated cachexia symptoms in tumor-bearing mice, while exercise training prevented muscle wasting in tumor-bearing mice. Also, aerobic interval training enhanced the anti-inflammatory indices IL-10/TNF-α ratio and IL-15 expression in skeletal muscle in tumor-bearing mice. However, combining exercise training and antioxidant supplementation prevented cachexia and muscle wasting and additionally decreased tumor volume in 4T1 breast cancer mice. These finding suggested that combining exercise training and antioxidant supplementation could be a strategy for managing tumor volume and preventing cachexia in breast cancer.

The impact of rapid weight loss on the leptin, adiponectin levels, and insulinresistance among adult free style wrestlers.

AIM: Recent studies, shows the effective role of adipose tissue as an active endocrine organ. Leptin level increases in obese bodies while adiponectin as an antirisk factor reduction that contributes to decrease insulin resistance and anthropometric profiles. Hence, expected to the negative effects of weight loss on wrestlers' physiological function; leptin and adiponectin behaviors and insulin resistance in young wrestlers during their rapid weight loss program were examined. METHODS: Fifteen young (23±1 yr) freestyle wrestlers with (weight 67.6±0.8 kg, BMI 22.5±0.2 kg/m²) in two (60 and 66 kg) weight categories were selected randomly. Caloric intake and anthropometric characteristics measured by standard methods. The leptin and adiponectin hormones and insulin resistance index were measured by sandwich and HOMA-IR methods respectively. Wrestlers performed a week rapid weight loss Protocol (average of 4% of body weight loss) under the supervision of their coach. Eventually, selected factors were measured after 12 and 24 hours of recovery, again. RESULTS: The rapid weight loss (4%) program had a significantly reduced impact on anthropometric factors; leptin level, insulin resistance, and increased beta cell function, while the changes of adiponectin were not significant after weight loss. CONCLUSION: Findings of this study shows that dramatic decrease in anthropometric factors follow the weight loss program that having a significant decrease on leptin, L/A ratio and HOMA-IR, without significant changes in adiponectin levels. These changes may have harmful physiological effects on wrestlers' bodies but they can be useful to regulate of fatty acid, glucose metabolism, and insulin resistance.